Menu

IFReC 大阪大学 免疫学フロンティア研究センター

RIMD 大阪大学 微生物病研究所

© 2023 Akira Lab.
Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University

業績Publications

  1. Sakaguchi T, Nagahama Y, Hamada N, Singh SK, Mikami H, Maeda K, Akira S. 2024.
    Novel Choline-Deficient and 0.1%-Methionine-Added High-Fat Diet Induces Burned-Out Metabolic-Dysfunction-Associated Steatohepatitis with Inflammation by Rapid Immune Cell Infiltration on Male Mice.
    Nutrients 16: 4151
  2. Lu YZ, Nayer B, Singh SK, Alshoibaki YK, Yuan E, Park AJ, Maruyama K, Akira S, Martino MM. 2024.
    CGRP sensory neurons promote tissue healing via neutrophils and macrophages.
    Nature 628: 604-611
  3. Kawai T, Ikegawa M, Ori D, Akira S. 2024.
    Decoding Toll-like receptors: Recent insights and perspectives in innate immunity.
    Immunity 57: 679-673
  4. Sun X, Nagahama Y, Singh SK, Kozakai Y, Nabeshima H, Fukushima K, Tanaka H, Motooka D, Fukui E, ViVier E, Diez D, Akira S. 2024.
    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng.
    Immunity 57: 1360-1377 e13
  5. Htun TS, Tanaka H Singh SK, Diez D, Akira S. 2024.
    Regnase-1 D141N mutation induces CD4+ T cell-mediated lung granuloma formation via upregulation of Pim2.
    Int Immunol 36: 497-516
  6. Hobro A, Sakaguchi T, Akira S, Smith NI. 2024.
    Correlative Quantitative Raman Chemical Imaging and MCR-ALS in Mouse NASH Model Reveals Direct Relationships between Diet and Resultant Liver Pathology.
    Chem Biomed Imaging 2: 577-583
  7. Morisaka H, Takaishi M, Akira S, Sano S. 2023.
    Keratinocyte Regnase-1, a downregulator of skin inflammation, contributes toprotection against tumor promotion by limiting Cyclooxygenase-2 expression.
    J Invest Dermatol 143: 731-739
  8. Piboonprai K, Millius A, Shimoda M, Tanaka H, Akira S, Maeda K. 2023.
    Breaking self-regulation of Regnase-1 promotes its own protein expression.
    Genes Cells 28: 383-389
  9. Akira S, Maeda K. 2021.
    Control of RNA Stability in Immunity.
    Annu Rev Immunol 39: 481-509
  10. Fukushima K, Satoh T, Sugihara F, Sato Y, Okamoto T, Mitsui Y, Yoshio S, Li S, Nojima S, Motooka D, Nakamura S, Kida H, Standley DM, Morii E, Kanto T, Yanagita M, Matsuura Y, Nagasawa T, Kumanogoh A, Akira S. 2020.
    Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis.
    Immunity 52: 542-56 e13
  11. Omiya S, Omori Y, Taneike M, Murakawa T, Ito J, Tanada Y, Nishida K, Yamaguchi O, Satoh T, Shah AM, Akira S, Otsu K. 2020.
    Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts.
    Circulation 141: 667-677
  12. Matsushita K, Tanaka H, Yasuda K, Adachi T, Fukuoka A, Akasaki S, Koida A, Kuroda E, Akira S, Yoshimoto T. 2020.
    Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation.
    JCI Insight 5: e131480
  13. Maeda K, Caldez MJ, Akira S. 2019.
    Innate immunity in allergy.
    Allergy 74: 1660-1674
  14. Tanaka H, Arima Y, Kamimura D, Tanaka Y, Takahashi N, Uehata T, Maeda K, Satoh T, Murakami M, Akira S. 2019.
    Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.
    J Exp Med 216: 1431-1449
  15. Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N. 2019.
    Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.
    Nat Commun 10: 1072
  16. Takaishi M, Satoh T, Akira S, Sano S. 2018.
    Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation.
    J Invest Dermatol 138: 1439-1442 
  17. Nagahama Y, Shimoda M, Mao G, Singh SK, Kozakai Y, Sun X, Motooka D, Nakamura S, Tanaka H, Satoh T, Maeda K, Akira S. 2018.
    Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism.
    Proc Natl Acad Sci U S A 115: 11036-11041
  18. Satoh T, Nakagawa K, Sugihara F, Kuwahara R, Ashihara M, Yamane F, Minowa Y, Fukushima K, Ebina I, Yoshioka Y, Kumanogoh A, Akira S. 2017.
    Identification of an atypical monocyte and committed progenitor involved in fibrosis.
    Nature 541: 96-101
  19. Maeda K, Akira S. 2017.
    Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells.
    Int Immunol 29: 149-155
  20. Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S. 2017.
    Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
    Proc Natl Acad Sci U S A 114: E7331-E40
  21. Martino MM, Maruyama K, Kuhn GA, Satoh T, Takeuchi O, Muller R, Akira S. 2016.
    Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.
    Nat Commun 7: 11051
  22. Yokogawa M, Tsushima T, Noda NN, Kumeta H, Enokizono Y, Yamashita K, Standley DM, Takeuchi O, Akira S, Inagaki F. 2016.
    Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions.
    Sci Rep 6: 22324
  23. Maeda K, Akira S. 2016.
    TLR7 Structure: Cut in Z-Loop.
    Immunity 45: 705-707