© 2023 Akira Lab.
Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University
- Akira S, Maeda K. 2021.
Control of RNA Stability in Immunity.
Annu Rev Immunol 39: 481-509 - Fukushima K, Akira S. 2021.
Novel insights into the pathogenesis of lung fibrosis: the RBM7-NEAT1-CXCL12-SatM axis at fibrosis onset.
Int Immunol 33: 659-63 - Fukushima K, Satoh T, Sugihara F, Sato Y, Okamoto T, Mitsui Y, Yoshio S, Li S, Nojima S, Motooka D, Nakamura S, Kida H, Standley DM, Morii E, Kanto T, Yanagita M, Matsuura Y, Nagasawa T, Kumanogoh A, Akira S. 2020.
Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis.
Immunity 52: 542-56 e13 - Omiya S, Omori Y, Taneike M, Murakawa T, Ito J, Tanada Y, Nishida K, Yamaguchi O, Satoh T, Shah AM, Akira S, Otsu K. 2020.
Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts.
Circulation 141: 667-77 - Matsushita K, Tanaka H, Yasuda K, Adachi T, Fukuoka A, Akasaki S, Koida A, Kuroda E, Akira S, Yoshimoto T. 2020.
Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation.
JCI Insight 5: e131480 - Maeda K, Caldez MJ, Akira S. 2019.
Innate immunity in allergy.
Allergy 74: 1660-74 - Tanaka H, Arima Y, Kamimura D, Tanaka Y, Takahashi N, Uehata T, Maeda K, Satoh T, Murakami M, Akira S. 2019.
Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.
J Exp Med 216: 1431-49 - Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N. 2019.
Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.
Nat Commun 10: 1072 - Takaishi M, Satoh T, Akira S, Sano S. 2018.
Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation.
J Invest Dermatol 138: 1439-42 - Nagahama Y, Shimoda M, Mao G, Singh SK, Kozakai Y, Sun X, Motooka D, Nakamura S, Tanaka H, Satoh T, Maeda K, Akira S. 2018.
Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism.
Proc Natl Acad Sci U S A 115: 11036-41 - Kanemaru H, Yamane F, Tanaka H, Maeda K, Satoh T, Akira S. 2018.
BATF2 activates DUSP2 gene expression and up-regulates NF-kappaB activity via phospho-STAT3 dephosphorylation.
Int Immunol 30: 255-65 - Nakagawa K, Matsuki T, Zhao L, Kuniyoshi K, Tanaka H, Ebina I, Yoshida KJ, Nabeshima H, Fukushima K, Kanemaru H, Yamane F, Kawasaki T, Machida T, Naito H, Takakura N, Satoh T, Akira S. 2018.
Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.
Int Immunol 30: 69-78 - Satoh T, Nakagawa K, Sugihara F, Kuwahara R, Ashihara M, Yamane F, Minowa Y, Fukushima K, Ebina I, Yoshioka Y, Kumanogoh A, Akira S. 2017.
Identification of an atypical monocyte and committed progenitor involved in fibrosis.
Nature 541: 96-101 - Maeda K, Akira S. 2017.
Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells.
Int Immunol 29: 149-55 - Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S. 2017.
Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
Proc Natl Acad Sci U S A 114: E7331-E40 - Martino MM, Maruyama K, Kuhn GA, Satoh T, Takeuchi O, Muller R, Akira S. 2016.
Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.
Nat Commun 7: 11051 - Yokogawa M, Tsushima T, Noda NN, Kumeta H, Enokizono Y, Yamashita K, Standley DM, Takeuchi O, Akira S, Inagaki F. 2016.
Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions.
Sci Rep 6: 22324 - Maeda K, Akira S. 2016.
TLR7 Structure: Cut in Z-Loop.
Immunity 45: 705-7