0870.

Tang CK, Aoshi T, Jounai N, Ito J, Ohata K, Kobiyama K, Dessailly BH, Kuroda E, Akira S, Mizuguchi K, Coban C, Ishii KJ.

The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant.

PLoS One. 2013:8(3):e60038. doi:10.1371/journal.pone.0060038. Epub 2013 Mar 21.

PMID:23555875

0869.

Akitake Y, Nakatani Y, Kamei D, Hosokawa M, Akatsu H, Uematsu S, Akira S, Kudo I, Hara S, Takahashi M.

Microsomal prostaglandin E synthase-1 is induced in alcheimer's disease and its delection mitigates alzheimer's disease-like pathology in a mouse model.

J Neurosci Res. 2013 Jul; 91(7):909-919. doi:10.1002/jnr. 23217. Epub 2013 Mar 29.

PMID:23553915

0868.

Fujiwara N, Porcelli SA, Naka T, Yano I, Maeda S, Kuwata H, Akira S, Uematsu S, Takii T, Ogura H Kobayashi K.

Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance.

Biochim Biophys Acta. 2013 Jun; 1831(6):1177-1184. doi: 10.1016/j.bbalip. 2013.03.008. Eoub 2013 Mar 29.

PMID:23545566

0867.

Lee JH, Kim TH, Oh SJ, Yoo JY, Akira S, Ku BJ, Lydon JP, Jeong JW.

Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus.

FASEB J. 2013 Jul; 27(7):2553-2563. doi:10.1096/fj.12-225664. Epub 2013 Mar 26.

PMID:23531596

0866.

Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S.

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.

Nature. 2013 Mar 28;495(7442):524-528. doi: 10.1038/nature11930. Epub 2013 Mar 20.

PMID: 23515163

0865.

Satoh T, Akira S.

Physiological roles and differentiation mechanism of M2 macrophage.

Nihon Rinsho. 2012 Nov;70 Suppl 8:236-241. Japanese. No abstract available.

PMID: 23513843

0864.

Ori D, Kato H, Sanjo H, Tartey S, Mino T, Akira S, Takeuchi O.

Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activaion via MAPKs.

J Immunol. 2013 Apr 15; 190(8):4037-4045. doi:10.4049/jimmunol. 1300173. Epub 2013 Mar 15.

PMID: 23509369

0863.

Misawa T, Takahama M, Kozaki T, LeeH, Zou J, Saitoh T, Akira S.

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.

Nat Immunol. 2013 Mar 17;14(5):454-460. doi: 10.1038/ni.2550. Epub 2013 Mar 17.

PMID: 23502856

0862.

Uehata T, Akira S.

mRNA degradation by the endoribonuclease Regnase-1/ZC3H12a/MCPIP-1.

Biochim Biophys Acta. 2013 June-July; 1829(6-7):708-713. doi:10.1016/j.bbagrm.2013.03.001. Epub 2013 Mar 13.

PMID:23500036

0861.

Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara SI, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H.

Histidine augments the suppression of hepatic glucose production by central insulin action.

Diabetes. 2013 Jul; 62(7):2266-2277. doi:10.2337/db12-1701. Epub 2013 Mar 8.

PMID: 23474485

0860.

Okuma A, Hoshino K, Ohba T, Fukushi S, Aiba S, Akira S, Ono M, Kaisho T, Muta T.

Enhanced Apoptosis by Disruption of the STAT3-Iκβ-ζ-Signaling Pathway in Epithelial Cells Induces Sjogren's Syndrome-like Autoimmune Disease.

Immunity. 2013 Mar 21;38(3):450-460. doi: 10.1016/j.immuni. 2012.11.016. Epub 2013 Feb 28.

PMID:23453632

0859.

Hoffmann J, Akira S.

Innate Immunity.

Curr Opin Immunol. 2013 Feb; 25(1):1-3. doi: 10.1016/j.coi.2013.01.008.No abstract available.

PMID:23452839

0858.

Lundberg AM, Ketelhuth DF, Johansson ME, Gerdes N, Liu S, Yamamoyo M, Akira S, Hansson GK.

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in hematopoietic cells promotes atherosclerosis.

Cardiovasc Res. 2013 Jul 15; 99(2):364-373. doi: 10.1093/cvr/cvt033. Epub 2013 Feb 14.

PMID:23417039

0857.

Fujikura D, Chiba S, Muramatsu D, Kazumata M, Nakayama Y, Kawai T, Akira S, Kida H, Miyazaki T.

Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza.

PLoS One. 2013; 8(2):e55321. doi: 10. 1371/journal.pone. 0055321. Epub 2013 Feb 8.

PMID:23408968

0856.

Sandig H, Jobbings CE, Roldan NG, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S.

IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.

Eur J Immunol. 2013 Apr, 43(4):979-988. doi: 10.1002/eji.201242876. Epub 2013 Mar 6.

PMID:23404570

0855.

Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N.

FIP200 regulates targeting of Atg16L1 to the isolation membrane.

EMBO Rep. 2013 Mar 1; 14(3):284-291. doi:10.1038/embor.2013.6. Epub 2013 Feb 8.

PMID:23392225

0854.

Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T.

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2969-2974. doi:10.1073/pnas. 1222694110. Epub 2013 Feb 6.

PMID:23388631

0853.

Vandenbon A, Kumagai Y, Teraguchi S, Amada KM, Akira S, Standley DM.

A Parzen window-based approach for the detection of locally enriched transcription factor binding sites.

BMC Bioinformatics. 2013 Jan 21; 14:26. doi:10.1186/1471-2105-14-26.

PMID:23331723

0852.

Takase HM, Itoh T, Ino S, Wang T, Koji T, Akira S, Takikawa Y, Miyajima A.

FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.

Genes Dev. 2013 Jan 15:27(2):169-181. doi:10.1101/gad.204776.112. Epub 2013 Jan 15.

PMID: 23322300

0851.

Vandenbon A, Kumagai Y, Akira S, Standley DM.

A novel unbiased measure for motif co-occurrence predicts combinatorial regulation of transcription.

BMC Genomics. 2012; 13 Suppl 7: S11: 10. 1186/1471-2164-13-S7-S11. Epub 2012 Dec 13.

PMID: 23282148

0850.

Takeuchi C, Matsumoto Y, Kohyama K, Uematsu S, Akira S, Yamagata K, Takemiya T.

Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis.

Neurochem Int. 2013 Feb; 62(3):271-280.doi:10.1016/j.neuint. 2012.12.007. Epub 2012 Dec 22.

PMID:23266396

0849.

Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, Hayden MS, Akira S, Sher A, Ghosh S.

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii.

Immunity. 2013 Jan 24; 38(1):119-130. doi:10.1016/j.immuni. 2012.09.016. Epub 2012 Dec 13.

PMID: 23246311

0848.

Maruyama K, Fukasaka M, Vandenbon A, Saitoh T, Kawasaki T, Kondo T, Yokoyama KK, Kidoya H, Takakura N, Standley D, Takeuchi O, Akira S. 

The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation.

Immunity. 2012 Dec 14; 37(6):1024-1036. doi:10.1016/j.immuni. 2012.08.022. Epub 2012 Nov 29.

PMID:23200825

0847.

Akira S, Saitoh T, Kawai T.

Nucleic acids recognition by innate immunity.

Uirusu. 2012 Jun; 62(1):39-45. Japanese

PMID:23189823

0846.

Zhao H, Konishi A, Fujita Y, Yagi M, Ohata K, Aoshi T, Itagaki S, Sato S, Narita H, Abdelgelil NH, Inoue M, Culleton R, Kaneko O, Nakagawa A, Horii T, Akira S, Ishii KJ, Coban C.

Lipocallin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism.

Cell Host Microbe. 2012 Nov 15; 12(5):705-716. doi: 10.10. 16/j.chom.2012.10.010.

PMID: 23159059

0845.

Stegemann-Koniszewski S, Gereke M, Orrskig S, Lienenklaus S, Pasche B, Bader SR, Gruber AD, Akira S, Weiss S, Henriwues-Normark B, Bruder D, Gunzer M.

TLR7 Contributes to the Rapid Progression but Not to the Overall Fatal Outcome of Secondary Pneumococcal Disease following Influenza A Virus Infection.

J Innate Immune. 2013;5(1):84-96. doi:10.1159/000345112. Epub 2012 Nov 15.

PIMD:23154432

0844.

Flores-Langarica A, Marshall JL, Hitchcock J, Cook C, Jobanputra J, Bobat S, Ross EA, Coughlan RE, Henderson IR, Uematsu S, Akira S, Cunningham AF.

Systemic Flagellin Immunization Stimulates Mucosal CD103+ Dendritic Cells and Drives Foxp3+ Regulatory T Cell and IgA Responses in the Mesenteric Lymph Node.

J Immunol. 2012 Dec 15;189(12):5745-5754. doi:10.4049/jimmunol. 1202283. Epub 2012 Nov 14.

PMID:23152564

0843.

Ichikawa A, Kuba K, Morita M, Chida S, Tezuka H, Hara H, Sasaki T, Ohteki T, Ranieri VM, Dos Santos CC, Kawaoka Y, Akira S, Luster AD, Lu B, Penninger JM, Uhlig S, Slutsky AS, Imai Y.

CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Non-viral Origin.

AM J Respir Crit Care Med. 2013 Jan 1;187(1):65-77. doi:10.1164/rccm.201203-0508OC. Epub 2012 Nov 9.

PMID:23144331

0842.

Demoor T, Petersen BC, Morris S, Mukherjee S, Ptaschincki C, De Almeida Nagata DE, Kawai T, Ito T, Akira S, Kunkel SL, Schaller MA, Lukacs NW.

IPS-1 Signaling Has a Nonredundant Role in Mediating Antiviral Responses and the Clearance of Respiratory Syncytial Virus.

J Immunol. 2012 Dec 15;189(129:5942-5953. doi:10.4049/jimmunol.1201763. Epub Nov 7.

PMID:23136205

0841.

Hernandez-Cuellar E, Tsuchiya K, Hara H, Fang R, Sakai S, Kawamura I, Akira S, Mitsuyama M.

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome.

J Immunol. Dec 1;189(11):5113-5117. doi: 10.4049/jimmunol. 1202479. Epub 2012 Oct 24. 

PMID:23100513

0840.

Shigekawa M, Hikita H, Kodama T, Shimizu S, Li W, Uemura A, Miyagi T, Hosui A, Kanto T, Hiramatsu N, Tatsumi T, Takeda K, Akira S, Takehara T.

Pancreatic STAT3 Protects Mice against Caerulein-Induced Pancreatitis via PAP1 Induction.

Am J Pathol. 2012 Dec; 181(69:2105-2113. doi: 10.1016/j-ajpath. 2012. 08. 038. Epub 2012 Oct 10.

PMID: 23064197

0839.

Vitry MA, De Trez C, Goriely S, Dumoutier L, Akira S, Ryffel B, Carlier Y, Letesson JJ, Muraille E.

Crucial role of IFN-γ-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2 and Th17 responses in the control of Brucella melitensis infection in mice.

Infect Immun. 2012 Dec; 80(12):4271-4280. doi: 10.1128/IAI.00761-12. Epub 2012 Sep 24.

PMID: 23006848

0838.

Moon SL, Anderson JR, Kumagai Y, Wilusz CJ, Akira S, Khromykh AA, Wilusz J.

A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability.

RNA. 2012 2012 Nov;18(11):2029-40. doi: 10.1261/rna.034330.112. Epub 2012 Sep 24.

PMID:23006624

0837.

Watanabe TM, Tsukasaki Y, Fujita H, Ichimura T, Saitoh T, Akira S, Yanagida T.

Distinct modulated pupil function system for real-time imaging of living cells.

PLoS One. 2012;7(9):e44028. Epub 2012 Sep 4.

PMID:22962597

0836.

Huang B, Takahashi K, Sakata-Goto T, Kiso H, Togo Y, Saito K, Tsukamoto H, Sugai M, Akira S, Shimizu A, Bessho K.

Phenotypes of CCAAT/enhancer-binding protein beta deficiency: hyperdonita and elongated coronoid process.

Oral Dis. 2013 Mar;19(2):144-150. doi: 10.1111/j.1601-0825.2012.01963.x. Epub 2012 Jul 31.

PMID:22849712

0835. Shibata T, Takemura N, Motoi Y, Goto Y, KAruppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K.

PRAT4A-dependent expression of cell surfate TLR5 on neutrophils, classical monocytes and dendritic cells.

Int Immunol. 2012 Oct; 24(10):613-623. Epub 2012 Jul 25.

PMID:22836022

0834.

Oldenburg M, Kruger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ.

TLR13 Recognize Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification.

Science. 2012 Aug 31; 337(6098):1111-1115. Epub 2012 Jul 19. 

PMID:22821982

0833.

Shoji M, Tachibana M, Katayama K, Tomita K, Tsuzuki S, Sakurai F, Kawabata K, Ishii KJ, Akira S, Mizuguchi H.

Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.

Biochem Biophys Res Commun. 2012 Aug 17;425(1):89-93. doi:10.1016/j.bbrc.2012.07.056. Epub Jul 20.

PMID:22819843

0832.

Saitoh T, Komano J, Saitoh Y. Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S.

Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.

Cell Host Microbe. 2012 Jul 19; 12(1):109-116.

PMID:22817992

0831.

Kreutz M, Giquel B, Hu Q, Abuknesha R, Uematsu S, Akira S, Nestle FO, Diebold SS.

Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity.

PLoS One. 2012;7(7):e40208. Epub 2012 Jul 10.

PMID:22808118

0830.

Maruyama K, Kawagoe T, Kondo T, Akira S, Takeuchi O.

TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.

J Biol Chem. 2012 Aug 17; 287(34):29114-29124. Epub 2012 Jul 6.

PMID:22773835

0829.

Kuroki Y, Sasaki Y, Kamei D, Akitake Y, Takahashi M, Uematsu S, Akira S, Nakatani Y, Kudo I, Hara S.

Delection of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35.

Biochem Biophys Res Commun. 2012 Aug 3; 424(3):409-413. Epub 2012 Jul 2.

PMID:22766501

0828.

Rudd PA, Wilson J, Gardner J, LArcher T, Babarit C, Le TT, Anraku I, Kumagai Y, Loo YM, Gale M Jr, Akira S, Khtomykh AA, Suhrbier A.

Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock.

J Virol. 2012 Sep; 86(18):9888-9898. Epub 2012 Jul 3.

PMID:22761364

0827.

Kondo T, Kawai T, Akira S.

Dissecting negative regulation of Toll-like receptor signaling.

Trends Immunol. 2012 Sep; 33(9):449-458. Epub 2012 Jun 20.

PMID:22721918

0826.

Vandenbon A, Teraguchi S, Akira S, Takeda K, Standley DM.

Systems biology approaches to toll-like receptor sicnaling.

Wiley Interdiscip Rev Syst Biol Med. 2012 Sep: 4(5)497-507. doi:10.1002/wsbm. 1178. Epub 2012 Jun 19.

PMID:22714995

0825.

Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein nP, Akira S, Uematsu S, Ash JD.

Leukemia Inhibitory Factor (LIF) coodinates the downregulation of the visual cycle in the retina and retinal pigmented epithelium (RPE).

J Biol Chem. 2012 Jul 13; 287(29):24092-24102. Epub 2012 May 29. 

PMID:22645143

0824.

Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A.

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain.

Nat Med. 2012 Jun; 18(6):911-917

PMID:22610280

0823.

Coulombe F, Fiola S, Akira S, Cormier Y, Gosselin J.

Muramyl dipeptide induces NOD2-dependent Ly6C(high) monocyte recruitment to the lungs and protects against influenza virus infection.

PLoS One. 2012; 7(5):e36734. Epub 2012 May 9.

PMID:22590599

0822.

Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K.

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.

Nature. 2012 May 10; 485(7397)251-255.

PMID:22535248

0821.

Berard JL, Zarruk JG, Arbour N, Prat A, Yong VW, Jacques FH, Akira S, David S.

Lipocalin 2 is a novel immune mediator of experimantal autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis.

Glia. 2012 Jul; 60(7):1145-1159. doi:10.1002/glia.22.42. Epub 2012 Apr 12.

PMID:22499213

0820.

Bradley LM, Douglass MF, Chatterjee D, Akira S, Baaten BJ.

Matrix Metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling.

PLoS Pathog. 2012 Apr; 8(4):e1002641. Epub 2012 Apr 5.

PMID:22496659

0819.

Abe T, Fukuhara T, Wen X, Ninomiya A, Moriishi K, Maehara Y, Takeuchi O, Kawai T, Akira S, Matsuura Y.

CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptro 2 and hyaluronan.

J Virol. 2012 Jun; 86(11):6159-6170. Epub 2012 Apr 4.

PMID:22491449

0818.

Chang JH, Xiao Y, Hu H, Jin J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC.

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.

Nat Immunol. 2012 May; 13(5):481-490.

PMID:22484734

0817.

Copin R, Vitry MA, Hanot Mambres D, Machelart A, De Trez C, Vanderwinden JM, Magez S, Akira S, Ryffel B, Carlier Y, Letesson JJ, Muraille E.

In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice.

PLoS Pathog. 2012 MAr; 8(3):e1002575. Epub 2012 Mar 29.

PMID:22479178

0816.

Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algul H, Akira S, Schmid RM, Pelton SL, Spira A, Mizgerd JP.

Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice.

J Clin Invest. 2012 May 1; 122(5):1758-1763. doi: 10.1172/JCI59408. Epub 2012 Apr 2.

PMID:22466650

0815.

Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T.

A critical role of IL-33 in experimental allergic rhinitis.

J Allergy Clin Immunol. 2012 Jul; 130(1):184-194. e11. Epub 2012 mar 27.

PMID:22460070

0814.

Lee G, Xu S, Kang ZH, Huo J, Huang M, Liu D, Takeuchi O, Akira S, Lam KP.

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response.

Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5791-5796. Epub 2012 Mar 27.

PMID:22454496

0813.

Aoshi T, Koyama S, Kobiyama K, Akira S, Ishii KJ.

Innate and adaptive immune responses to viral infection and vaccination.

Curr Opin Virol. 2011 Oct; 1(4):226-232. Epub 2011 Jul 30.

PMID:22440781

0812.

Yoshioka W, Aida-Yasuoka K, Fujisawa N, Kawaguchi T, Ohsako S, Hara S, Uematsu S, Akira S, Tohyama C.

Critical role of microsomal prostaglandin e synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.

Toxicol Sci. 2012 Jun; 127(2):547-554. Epub 2012 Mar 19.

PMID:22430074

0811.

Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S.

Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes.

J Allergy Clin Immunol. 2012 May; 129(5):1413-1416. e11. Epub 2012 Mar 14. No abstract available.

PMID:22421267

0810.

Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama HO, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y.

The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.

Diabetes. 2012 May; 61(5):1199-1209. Epub 2012 Mar 6.

PMID:22396206

0809.

Schuessler A, Funk A, Lazear HM, Cooper DA, Torres S, Daffis S, Jha BK, Kumagai Y, Takeuchi O, Hertzog P, Silverman R, Akira S, Barton DJ, Diamond MS, Khromykh AA.

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response.

J Virol. 2012 May; 86(10):5708-5718. Epub 2012 Feb 29.

PIMD:22379089

0808.

Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishii KJ, Yoshimoto T, Akira S, Nakanishi K.

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice.

Proc Natl Acad ci U S A. 2012 Feb 28; 109(9):3451-3456. Epub 2012 Feb 13.

PIMD:22331917

0807.

Teraguchi S, Kumagai Y, Vandenbon A, Akira S, Standley DM.

Stochastic binary modeling of cells in continuous time as an alternative to biochemical reaction equations.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Dec; 84(6 Pt 1):062903. Epub 2011 Dec 15.

PMID:22304139

0806.

Kurokawa K, Ryu KH, Ichikawa R, Masuda A, Kim MS, Lee H, Chae JH, Shimizu T, Saitoh T, Kuwano K, Akira S, Dohmae N, Nakayama H, Lee BL.

Novel bacterial lipoprotein structures conserved in low-GC content gram-positive bacteria are recognized by Toll-like receptor 2.

J Biol Chem. 2012 Apr 13; 287(16):13170-13181. Epub 2012 Feb 2.

PMID: 22303020

0805.

Surendran N, Hiltbold EM, Heid B, Akira S, Standiford TJ, Sriranganathan N, Boyle SM, Zimmerman KL, Makris MR, Witonsky SG.
Role of TLRs in Brucella mediated murine DC activation in vitro and clearance of pulmonary infection in vivo.
Vaccine. 2012 Feb 14; 30(8):1502-1512. Epub 2012 Jan 9.
PMID: 22234268

0804.

Deshmukh SD, Müller S, Hese K, Rauch KS, Wennekamp J, Takeuchi O, Akira S, Golenbock DT, Henneke P.
NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA.
J Immunol. 2012 Jan 15;188(2):774-80. Epub 2011 Dec 19.
PMID: 22184724

0803.

Abe Y, Fujii K, Nagata N, Takeuchi O, Akira S, Oshiumi H, Matsumoto M, Seya T, Koike S.
The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice.
J Virol. 2012 Jan;86(1):185-94. Epub 2011 Nov 9.
PMID: 22072781

0802.

Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M.
Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.
Nat Neurosci. 2011 Dec 4;15(1):98-106. doi: 10.1038/nn.2964.
PMID: 22138643

0801.

Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama I, Ma Y, Chua KJ, Suematsu T, Shimokawa I, Akira S, Kubo Y, Mak TW, Matsuyama T.
Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18766-71. Epub 2011 Oct 31.
PMID: 22042864

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