0800.

Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.
Nat Immunol. 2011 Oct 30; 12(12):1167-1175. doi: 10.1038/ni.2137.

PMID: 22037600

0799.

Goh ET, Arthur JS, Cheung PC, Akira S, Toth R, Cohen P.
Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.
Biochem J. 2012 Jan 1; 441(1):339-346. Epub 2011 Oct 18.

PMID: 22007846

0798.

Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight DA, Kunkel SL, Uematsu S, Akira S, Hogaboam CM.
The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.
J Clin Invest. 2011 Nov; 121(11):4420-4432. doi: 10.1172/JCI44999. Epub 2011 Oct 17.
PMID: 22005301

0797.

Sasaki Y, Kamei D, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Hara S.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Oncogene. 2012 Jun 14;31(24):2943-2952. doi: 10.1038/onc.2011.472. Epub 2011 Oct 10.
PMID: 21986945

0796.

Clark K, Takeuchi O, Akira S, Cohen P.
The TRAF-associated protein TANK facilitates cross-talk within the I{kappa}B kinase family during Toll-like receptor signaling.
Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17093-17098. Epub 2011 Sep 23.
PMID: 21949249 

0795.

Rathore KI, Berard JL, Redensek A, Chierzi S, Lopez-Vales R, Santos M, Akira S, David S.
Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury.
J Neurosci. 2011 Sep 21;31(38):13412-9.
PMID: 21940434

0794.

Kim HS, Go H, Akira S, Chung DH.
TLR2-Mediated Production of IL-27 and Chemokines by Respiratory Epithelial Cells Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice.
J Immunol. 2011 Oct 15; 187(8): 4007-4017. Epub 2011 Sep 19.
PMID: 21930967

0793.

Kang SM, Yoo DG, Kim MC, Song JM, Park MK, Eunju O, Quan FS, Akira S, Compans RW.
MyD88 plays an essential role in inducing B cells capable of differentiating into antibody secreting cells after vaccination.
J Virol. 2011 Nov; 85(21):11391-11400. Epub 2011 Aug 24.
PMID: 21865389

0792.

Choi HJ, Kim MK, Ko JH, Lee HJ, Jeong HJ, Wee WR, Seong SY, Akira S.
Effect of Toll-like receptor 2 and 4 of corneal fibroblasts on cytokine expression with co-cultured antigen presenting cells.
Cytokine. 2011 Nov; 56(2):265-271. Epub 2011 Aug 4.
PMID: 21820318

0791.

Barker TT, Lee PY, Kelly-Scumpia KM, Weinstein JS, Nacionales DC, Kumagai Y, Akira S, Croker BP, Sobel ES, Reeves WH, Satoh M.
Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane.
Lab Invest. 2011 Oct; 91(10): 1540-1550. doi: 10.1038/labinvest.2011.108. Epub 2011 Aug 1.
PMID: 21808234

0790.

Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ, Bureau F, Desmet CJ.
DNA released from dying host cells mediates aluminum adjuvant activity.
Nat Med. 2011 Jul 17;17(8):996-1002. doi: 10.1038/nm.2403.
PMID: 21765404

0789.

Kelly-Scumpia KM, Scumpia PO, Weinstein JS, Delano MJ, Cuenca AG, Nacionales DC, Wynn JL, Lee PY, Kumagai Y, Efron PA, Akira S, Wasserfall C, Atkinson MA, Moldawer LL.
B cells enhance early innate immune responses during bacterial sepsis.
J Exp Med. 2011 Aug 1; 208(8):1673-1682. Epub 2011 Jul 11.
PMID: 21746813

0788.

Fukui R, Saitoh SI, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K.
Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking.
Immunity. 2011 Jul 22; 35(1):69-81. Epub 2011 Jun 16.
PMID: 21683627

0787.

Kim YG, Park JH, Reimer T, Baker DP, Kawai T, Kumar H, Akira S, Wobus C, Núñez G.
Viral infection augments nod1/2 signaling to potentiate lethality associated with secondary bacterial infections.
Cell Host Microbe. 2011 Jun 16;9(6):496-507.
PMID: 21669398

0786.

Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S.
A New Subset of CD103+CD8{alpha}+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity.
J Immunol. 2011 Jun .; 186(11):6287-6295. Epub 2011 Apr 27. 
PMID: 21525388

0785.

Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T.
The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.
Mol Biol Cell. 2011 Jul 1; 22(139:2290-2300. Epub 2011 Apr 27.
PMID: 21525242

0784.

Kuroda E, Ishii KJ, Uematsu S, Ohata K, Coban C, Akira S, Aritake K, Urade Y, Morimoto Y.
Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms.
Immunity. 2011 Apr 22;34(4):514-26. Epub 2011 Apr 14.
PMID: 21497116

0783.

Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC, Cherayil BJ.
Regulation of Lipopolysaccharide-Induced Translation of Tumor Necrosis Factor-Alpha by the Toll-Like Receptor 4 Adaptor Protein TRAM.
J Innate Immun. 2011; 3(5):437-446. Epub 2011 Apr 14.
PMID: 21494017

0782.

Davidson S, Kaiko G, Loh Z, Lalwani A, Zhang V, Spann K, Foo SY, Hansbro N, Uematsu S, Akira S, Matthaei KI, Rosenberg HF, Foster PS, Phipps S.
Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway.
J Immunol. 2011 MAy 15; 186(10):5938-5948. Epub 2011 Apr 11. 
PMID: 21482736

0781.

Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H.
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G,
Cancer Cell. 2011 Apr 12;19(4):456-69.
PMID: 21481788

0780.

Fukuda A, Wang SC, Morris JP 4th, Folias AE, Liou A, Kim GE, Akira S, Boucher KM, Firpo MA, Mulvihill SJ, Hebrok M.
Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression.
Cancer Cell. 2011 Apr 12;19(4):441-55.
PMID: 21481787

0779.

Neubert M, Ridder DA, Bargiotas P, Akira S, Schwaninger M.
Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia.
Cell Death Differ. 2011 Sep; 18(9):1521-1530. doi: 10. 1038/cdd.2011.29.  Epub 2011 Apr 8.
PMID: 21475303

0778.

Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Okazaki Y, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T.
Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway.
Cell Metab. 2011 Apr 6;13(4):401-12.
PMID: 21459325

0777.

Togi S, Ikeda O, Kamitani S, Nakasuji M, Sekine Y, Muromoto R, Nanbo A, Oritani K, Kawai T, Akira S, Matsuda T.
Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4.
J Biol Chem. 2011 May 27; 286(21):19170-19177. Epub 2011 Mar 30. 
PMID: 21454679

0776.

Letran SE, Lee SJ, Atif SM, Flores-Langarica A, Uematsu S, Akira S, Cunningham AF, McSorley SJ.
TLR5-Deficient Mice Lack Basal Inflammatory and Metabolic Defects but Exhibit Impaired CD4 T Cell Responses to a Flagellated Pathogen.
J Immunol. 2011 May 1; 186(9): 5406-5412. Epub 2011 Mar 30.
PMID:21451112

0775.

Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.
Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells.
Immunity. 2011 Mar 25;34(3):352-63.
PMID: 21435586

0774.

Fei M, Bhatia S, Oriss TB, Yarlagadda M, Khare A, Akira S, Saijo S, Iwakura Y, Fallert Junecko BA, Reinhart TA, Foreman O, Ray P, Kolls J, Ray A.
TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection.
Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5360-5. Epub 2011 Mar 14.
PMID: 21402950

0773.

Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, Flavell RA, Akira S, McKenzie AN, Fallon PG.
Impaired Basophil Induction Leads to an Age-Dependent Innate Defect in Type 2 Immunity during Helminth Infection in Mice.
J Immunol. 2011 Apr 15;186(8):4631-9. Epub 2011 Mar 11.
PMID: 21398616 

0772.

Seo SU, Kwon HJ, Ko HJ, Byun YH, Seong BL, Uematsu S, Akira S, Kweon MN.
Type I Interferon Signaling Regulates Ly6C Monocytes and Neutrophils during Acute Viral Pneumonia in Mice.
PLoS Pathog. 2011 Feb;7(2):e1001304. Epub 2011 Feb 24.
PMID: 21383977

0771.

Jung ID, Jeong SK, Lee CM, Noh KT, Heo DR, Shin YK, Yun CH, Koh WJ, Akira S, Whang J, Kim HJ, Park WS, Shin SJ, Park YM.
Enhanced Efficacy of Therapeutic Cancer Vaccines Produced by Co-Treatment with Mycobacterium tuberculosis Heparin-Binding Hemagglutinin, a Novel TLR4 Agonist.
Cancer Res. 2011 Apr 15;71(8):2858-2870. Epub 2011 Mar 2.
PMID: 21368092

0770.

Isono M, Suzuki T, Hosono K, Hayashi I, Sakagami H, Uematsu S, Akira S, Declerck YA, Okamoto H, Majima M.
Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice.
Life Sci. 2011 Apr 11;88(15-16):693-700. Epub 2011 Feb 12.
PMID: 21324324

0769.

Bourgeois C, Majer O, Frohner IE, Lesiak-Markowicz I, Hildering KS, Glaser W, Stockinger S, Decker T, Akira S, Müller M, Kuchler K.
Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-beta signaling.
J Immunol. 2011 Mar 1;186(5):3104-12. Epub 2011 Jan 31.
PMID: 21282509

0768.

Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T.
Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+CD11c+ cells.
Eur Respir J. 2011 Sep; 38(3):688-701. Epub 2011 Jan 27.
PMID: 21273385

0767.

Andrews DM, Chow MT, Ma Y, Cotterell CL, Watt SV, Anthony DA, Akira S, Iwakura Y, Trapani JA, Zitvogel L, Smyth MJ.
Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin.
Immunol Cell Biol. 2011 Aug; 89(6):739-746. doi: 10.1038/icb.2010.168. Epub 2011 Jan 25.
PMID: 21263463

0766.

Lousberg EL, Diener KR, Fraser CK, Phipps S, Foster PS, Chen W, Uematsu S, Akira S, Robertson SA, Brown MP, Hayball JD.
Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated Innate Immune Recognition.
J Virol. 2011 Apr;85(7):3385-96. Epub 2011 Jan 19.
PMID: 21248035

0765.

Numao A, Hosono K, Suzuki T, Hayashi I, Uematsu S, Akira S, Ogino Y, Kawauchi H, Unno N, Majima M.
The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model.
Biomed Pharmacother. 2011 Feb;65(1):77-84. Epub 2010 Dec 30.
PMID: 21247731 [PubMed - in process]

0764.

Bhatia S, Fei M, Yarlagadda M, Qi Z, Akira S, Saijo S, Iwakura Y, van Rooijen N, Gibson GA, St Croix CM, Ray A, Ray P.
Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype.
PLoS One. 2011 Jan 5;6(1):e15943.
PMID: 21246055

0763.

Takemiya T, Matsumura K, Sugiura H, Yasuda S, Uematsu S, Akira S, Yamagata K.
Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels.
Neurochem Int. 2011 Mar;58(4):489-96. Epub 2011 Jan 8.
PMID: 21219953

0762.

Letran SE, Lee SJ, Atif SM, Uematsu S, Akira S, McSorley SJ.
TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.
Eur J Immunol. 2011 Jan;41(1):29-38. doi: 10.1002/eji.201040717. Epub 2010 Dec 3.
PMID: 21182074 

0761.

Chang YJ, Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano N, Singh A, Bhatt A, Besra GS, Elzen P, Appelmelk B, Franck RW, Chen G, Dekruyff RH, Shimamura M, Illarionov P, Umetsu DT.
Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.
J Clin Invest. 2011 Jan 4;121(1):57-69. doi: 10.1172/JCI44845. Epub 2010 Dec 13.
PMID: 21157038 

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