0699.

Burns E, Eliyahu T, Uematsu S, Akira S, Nussbaum G.
TLR2-Dependent Inflammatory Response to Porphyromonas gingivalis Is MyD88 Independent, whereas MyD88 Is Required To Clear Infection.
J Immunol. 2010 Feb 1; 184(3):1455-1462. Epub 2009 Dec 30. 
PMID: 20042569

0698.

Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S.
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.
J Exp Med. 2009 Dec 21; 206(13):2879-2888. Epub 2009 Dec 14.
PMID: 20008526 

0697.

Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T.
Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal {beta}-Glucan.
J Immunol. 2009 Dec 15;183(12):8061-8067.
PMID: 20007575 [PubMed - as supplied by publisher]

0696.

Kihara Y, Matsushita T, Kita Y, Uematsu S, Akira S, Kira JI, Ishii S, Shimizu T.
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21807-21812. doi:10.1073/pnas.0906891106. Epub 2009 Dec 7.
PMID: 19995978 [PubMed - as supplied by publisher]

0695.

Conrad ML, Ferstl R, Teich R, Brand S, Blümer N, Yildirim AO, Patrascan CC, Hanuszkiewicz A, Akira S, Wagner H, Holst O, von Mutius E, Pfefferle PI, Kirschning CJ, Garn H, Renz H.
Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78.
J Exp Med. 2009 Dec 21;206(13):2869-2877. doi:10.1084/jem.20090845. Epub 2009 Dec 7.
PMID: 19995952

0694. Matsuda T, Kido Y, Asahara SI, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M. 
Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. 
J Clin Invest. 2010 Jan;120(1):115-126. doi: 10.1172/JCI39721. Epub 2009 Dec 1.
PMID: 19955657
0693. Broglie P, Matsumoto K, Akira S, Brautigan DL, Ninomiya-Tsuji J.
A TAK1 kinase adaptor, TAB2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in TNF signaling pathway.
J Biol Chem. 2010 Jan 22;285(4):2333-2339. doi:10.1074/jbc.M109.090522. Epub 2009 Dec 2.
PMID: 19955178
0692. Reimer T, Shaw MH, Franchi L, Coban C, Ishii KJ, Akira S, Horii T, Rodriguez A, Núñez G. 
Experimental Cerebral Malaria Progresses Independently of the Nlrp3 Inflammasome. 
Eur J Immunol. 2010 Mar;40(3):764-769. doi:10.1002/eji.200939996.
PMID: 19950187
0691. Santiago-Raber ML, Dunand-Sauthier I, Wu T, Li QZ, Uematsu S, Akira S, Reith W, Mohan C, Kotzin BL, Izui S.
Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice.
J Autoimmun. 2010 Jun;34(4):339-348. doi:10.1016/j.jaut.2009.11.001. Epub 2009 Nov 26.
PMID: 19944565
0690. Talbot S, Tötemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE. 
Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance. 
Immunology. 2009 Dec;128(4):472-83. 
PMID: 19930040
0689. Wu X, Yamamoto M, Akira S, Sun SC. 
Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13. 
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20836-20841. doi:10.1073/pnas.0906547106. Epub 2009 Nov 19.
PMID: 19926860
0688. Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S.
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. 
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-20846. doi:10.1073/pnas.0911267106. Epub 2009 Nov 19. 
PMID: 19926846
0687. Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J. 
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1beta production. 
Nat Immunol. 2010 Jan;11(1):63-69. doi:10.1038/ni.1824. Epub 2009 Nov 15.
PMID: 19915568
0686. Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani L, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T. 
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. 
Nature. 2009 Nov 5;462(7269):99-103. 
PMID: 19890330
0685. Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I. 
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 
Biochem J. 2009 Dec 23;425(2):361-371. doi:10.1042/BJ20090045.
PMID: 19845504
0684. Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, Akira S, Hayashi H, Su B, Inoue J. 
Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling.
Sci Signal. 2009 Oct 20;2(93):ra66. 
PMID: 19843958
0683. Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue JI, Penninger JM, Kunisawa J, Kiyono H. 
Id2-, ROR{gamma}t-, and LT{beta}R-independent initiation of lymphoid organogenesis in ocular immunity. 
J Exp Med. 2009 Oct 26;206(11):2351-2364. doi:10.1084/jem.20091436. Epub 2009 Oct 12. 
PMID: 19822644
0682. Lee PY, Li Y, Kumagai Y, Xu Y, Weinstein JS, Kellner ES, Nacionales DC, Butfiloski EJ, van Rooijen N, Akira S, Sobel ES, Satoh M, Reeves WH. 
Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation. 
Am J Pathol. 2009 Nov;175(5):2023-2033. doi:10.2353/ajpath.2009.090328. Epub 2009 Oct 1. 
PMID: 19808647
0681. Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, Taniguchi T. 
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. 
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17870-17875. doi:10.1073/pnas.0909545106. Epub 2009 Oct 1. 
PMID: 19805092
0680. Fujita N, Saitoh T, Kageyama S, Akira S, Noda T, Yoshimori T. 
Differencial involvement of ATG16L1 in Crohn disease and canonical autophagy: analysis of the organization of the ATG16L1 complex in fibroblasts. 
J Biol Chem. 2009 Nov 20;284(47):32602-32609. doi:10.1074/jbc.M109.037671. Epub 2009 Sep 25.
PMID: 19783656
0679. Papon L, Oteiza A, Imaizumi T, Kato H, Brocchi E, Lawson TG, Akira S, Mechti N. 
The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. 
Virology. 2009 Oct 25;393(2):311-318. doi:10.1016/j.virol.2009.08.009. Epub 2009 Sep 4. 
PMID: 19733381
0678. Nairz M, Theurl I, Schroll A, Theurl M, Fritsche G, Lindner E, Seifert M, Crouch ML, Hantke K, Akira S, Fang FC, Weiss G.
Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2. 
Blood. 2009 Oct 22;114(17):3642-3651. doi:10.1182/blood-2009-05-223354. Epub 2009 Aug 21. 
PMID: 19700664
0677. Kubo T, Uchida Y, Watanabe Y, Abe M, Nakamura A, Ono M, Akira S, Takai T. 
Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity. 
J Exp Med. 2009 Aug 31;206(9):1971-1982. doi:10.1084/jem.20082392. Epub 2009 Aug 17.  
PMID: 19687229
0676. Pan ZJ, Maier S, Schwarz K, Azbill J, Akira S, Uematsu S, Farris AD. 
TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells. 
Ann Rheum Dis. 2010 Jun;69(6):1195-1199. doi:10.1136/ard. 2009.108282. Epub 2009 Aug 11. 
PMID: 19674980
0675. Kawagoe T*, Takeuchi O*, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S. 
*contributed equally
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. 
Nat Immunol. 2009 Sep;10(9):965-972. doi:10.1038/ni.1771. Epub 2009 Aug 9. 
PMID: 19668221
0674. Takemiya T, Matsumura K, Sugiura H, Maehara M, Yasuda S, Uematsu S, Akira S, Yamagata K. 
Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate. 
J Neurosci Res. 2010 Feb 1;88(2):381-390. doi:10.1002/jnr.22195.
PMID: 19658194
0673. Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, Akira S, Way M, Schiavo G, Reis E Sousa C. 
Activation of MDA5 requires higher order RNA structures generated during virus infection. 
J Virol. 2009 Oct;83(20):10761-10769. doi:10.1128/JVI.00770-09. Epub 2009 Aug 5.
PMID: 19656871
0672. McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, Ishii KJ, Akira S, Colonna M, Chen ZJ, Fitzgerald KA, Hayakawa Y, Vance RE. 
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. 
J Exp Med. 2009 Aug 31;206(9):1899-1911. doi:10.1084/jem.20082874. Epub 2009 Aug 3.
PMID: 19652017
0671. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. 
Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes. 
J Immunol. 2009 Sep 1;183(5):3109-3117. doi.10.4049/jimmunol.0900399. Epub 2009 Jul 31.
PMID: 19648272
0670. Li HM, Fujikura D, Harada T, Uehara J, Kawai T, Akira S, Reed JC, Iwai A, Miyazaki T. 
IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation. 
Cell Death Differ. 2009 Dec;16(12):1615-1621. doi:10.1038/cdd.2009.97. Epub 2009 Jul 31.  
PMID: 19644511
0669. Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S. 
Poly I:C-Induced Activation of NK Cells by CD8{alpha}+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways. 
J Immunol. 2009 Aug 15;183(4):2522-2528. doi:10.4049/jimmunol.0901500. Epub 2009 Jul 27. 
PMID: 19635904
0668. Kayama H, Koga R, Atarashi K, Okuyama M, Kimura T, Mak TW, Uematsu S, Akira S, Takayanagi H, Honda K, Yamamoto M, Takeda K. 
NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. 
PLoS Pathog 2009 Jul;5(7):e1000514. Epub 2009 Jul 17. 
PMID: 19609356
0667. Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G. 
Recognition of 5' Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus. 
Immunity. 2009 jul 17;31(1):25-34. doi:10.1016/j.immunol. 2009.05.008. Epub 2009 Jul 2. 
PMID: 19576794
0666. Takashima K, Matsunaga N, Yoshimatsu M, Hazeki K, Kaisho T, Uekata M, Hazeki O, Akira S, Iizawa Y, Ii M. 
Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. 
Br J Pharmacol. 2009 Aug;157(7):1250-1262. doi:10.1111/j.1476-5381.2009.00297
x. Epub 2009 Jun 25.
PMID: 19563534
0665. De Trez C, Magez S, Akira S, Ryffel B, Carlier Y, Muraille E. 
iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice. 
PLoS Pathog. 2009 Jun;5(6):e1000494. Epub 2009 Jun 26. 
PMID: 19557162 [PubMed - in process]
0664.
Delaloye J, Roger T, Steiner-Tardivel QG, Le Roy D, Knaup Reymond M, Akira S, Petrilli V, Gomez CE, Perdiguero B, Tschopp J, Pantaleo G, Esteban M, Calandra T.
Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome.
PLoS Pathog. 2009 Jun;5(6):e1000480. Epub 2009 Jun 19.
PMID: 19543380 [PubMed - in process]
0663.
Shin OS, Miller LS, Modlin RL, Akira S, Uematsu S, Hu LT.
Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.
J Immunol. 2009 Jul 1;183(1):491-8.
PMID: 19542460 [PubMed - in process]
0662.
Tirapu I, Giquel B, Alexopoulou L, Uematsu S, Flavell R, Akira S, Diebold SS.
PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation.
Int Immunol. 2009 Jul;21(7):871-9. Epub 2009 Jun 7.
PMID: 19505890 [PubMed - in process]
0661.
Imamura M, Tsutsui H, Yasuda K, Uchiyama R, Yumikura-Futatsugi S, Mitani K, Hayashi S, Akira S, Taniguchi SI, Rooijen NV, Tschopp J, Yamamoto T, Fujimoto J, Nakanishi K.
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.
J Hepatol. 2009 Aug;51(2):333-341. doi:10.1016/j.jhep.2009.03.027. Epub 2009 May 20.
PMID: 19501931
0660.
Bates JT, Uematsu S, Akira S, Mizel SB.
Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin.
J Immunol. 2009 Jun 15;182(12):7539-47.
PMID: 19494277 [PubMed - in process]
0659.
Raetzsch CF, Brooks NL, Alderman JM, Moore KS, Hosick PA, Klebanov S, Akira S, Bear JE, Baldwin AS, Mackman N, Combs TP.
Lipopolysaccharide inhibition of glucose production through the Toll-like receptor-4, myeloid differentiation factor 88, and nuclear factor kappab pathway.
Hepatology. 2009 Aug;50(2):592-600. doi:10.1002/hep.22999.
PMID: 19492426
0658.
Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K, Goto H, Kato A, Yujiri T, Imai T, Kawaguchi Y, Su B, Takeuchi O, Akira S, Tsunetsugu-Yokota Y, Inoue J.
TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.
PLoS One. 2009 May 25;4(5):e5674.
PMID: 19479062 [PubMed - in process]
0657. Abe T, Kaname Y, Wen X, Tani H, Moriishi K, Uematsu S, Takeuchi O, Ishii KJ, Kawai T, Akira S, Matsuura Y.
Baculovirus induces type I IFN production through TLR-dependent and -independent pathways in a cell type-specific manner.
J Virol. 2009 Aug;83(15):7629-7640. doi:10.1128/JVI.00679-09. Epub 2009 May 27.
PMID: 19474102
0656. Lu YC, Kim I, Lye E, Shen F, Suzuki N, Suzuki S, Gerondakis S, Akira S, Gaffen SL, Yeh WC, Ohashi PS.
Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines.
J Immunol. 2009 Jun 1;182(11):7212-21.
PMID: 19454718 [PubMed - in process]
0655. Miyazato A, Nakamura K, Yamamoto N, Mora-Montes HM, Tanaka M, Abe Y, Tanno D, Inden K, Gang X, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Mitsutake K, Gow NA, Kaku M, Kawakami K.
Toll-like receptor 9-dependent activation of myeloid dendritic cells by deoxynucleic acids from Candida albicans.
Infect Immun.2009 Jul;77(7):3056-3064. doi:10.1128/iAI.00840-08. Epub  2009 May 11.
PMID: 19433551
0654. Mancuso G, Gambuzza M, Midiri A, Biondo C, Papasergi S, Akira S, Teti G, Beninati C.
Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells.
Nat Immunol. 2009 Jun;10(6):587-94.
PMID: 19430477 [PubMed - in process]
0653. Janot L, Sirard JC, Secher T, Noulin N, Fick L, Akira S, Uematsu S, Didierlaurent A, Hussell T, Ryffel B, Erard F.
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
Eur J Immunol. 2009 Jun;39(6):1587-1596. doi:10.1002/eji.200838907.
PMID: 19424969
0652. Ueta M, Uematsu S, Akira S, Kinoshita S.
Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis.
J Allergy Clin Immunol. 2009 May;123(5):1187-1189. doi:10.1016/j.jaci.2009.03.008. Epub 2009 Apr 10.
PubMed PMID: 19362356.
0651. Kenzel S, Santos-Sierra S, Deshmukh SD, Moeller I, Ergin B, Fitzgerald KA, Lien E, Akira S, Golenbock DT, Henneke P.
ROLE OF P38 AND EGR-1 IN THE MACROPHAGE RESPONSE TO GROUP B STREPTOCOCCUS.
Infect Immun. 2009 Jun;77(6):2474-2481. doi:10.1128/IAI.01343-08. Epub 2009 Mar 30.
PMID: 19332535
0650. Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S.
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.
Nature. 2009 Apr 30;458(7242):1185-1190. doi:10.1038/nature07924. Epub 2009 Mar 25.
PMID: 19322177
0649. Tsuchiya M, Piras V, Choi S, Akira S, Tomita M, Giuliani A, Selvarajoo K.
Emergent genome-wide control in wildtype and genetically mutated lipopolysaccarides-stimulated macrophages.
PLoS ONE. 2009;4(3):e4905. Epub 2009 Mar 20.
PMID: 19300509 [PubMed - in process
0648. Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, Radeke HH.
Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells.
J Immunol. 2009 Apr 1;182(7):4183-91.
PMID: 19299716 [PubMed - in process]
0647. Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S.
Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.
J Immunol. 2009 Apr 1;182(7):3960-4.
PMID: 19299691 [PubMed - in process]
0646. Li L, Tanaka T, Yukawa K, Akira S, Umesaki N.
Irinotecan-induced ovarian follicular apoptosis is attenuated by deleting the kinase domain of death-associated protein kinase.
Int J Oncol. 2009 Apr;34(4):905-14.
PMID: 19287947 [PubMed - in process]
0645. Kobayashi T, Kim TS, Jacob A, Walsh MC, Kadono Y, Fuentes-Panan? E, Yoshioka T, Yoshimura A, Yamamoto M, Kaisho T, Akira S, Monroe JG, Choi Y.
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.
PLoS ONE. 2009;4(3):e4736. Epub 2009 Mar 9.
PMID: 19270748 [PubMed - in process]
0644. Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T, Akira S, Noda T, Yoshimori T.
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
Nat Cell Biol. 2009 Apr;11(4):385-396. doi:10.1038/ncb1846. Epub 2009 Mar 8.
PMID: 19270696
0643. Allard JB, Rinaldi L, Wargo MJ, Allen G, Akira S, Uematsu S, Poynter ME, Hogan DA, Rincon M, Whittaker LA.
Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products.
Eur J Immunol. 2009 Mar;39(3):776-88.
PMID: 19224641 [PubMed - in process]
0642. van Zoelen MA, Yang H, Florquin S, Meijers JC, Akira S, Arnold B, Nawroth PP, Bierhaus A, Tracey KJ, Poll T.
Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo.
Shock. 2009 Mar;31(3):280-4.
PMID: 19218854 [PubMed - indexed for MEDLINE]
0641. Kim JH, Kim SJ, Lee IS, Lee MS, Uematsu S, Akira S, Oh KI.
Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway.
J Immunol. 2009 Feb 15;182(4):2458-66.
PMID: 19201901 [PubMed - indexed for MEDLINE]
0640. Pejnovic N, Vratimos A, Lee SH, Popadic D, Takeda K, Akira S, Chan WL.
Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet.
Mol Immunol. 2009 Nov;47(1):37-45. doi:10.1016/j.molimm.2008.12.032. Epub 2009 Feb 8.
PMID: 19201478
0639. Jose P, Avdiushko MG, Akira S, Kaplan AM, Cohen DA.
Inhibition of interleukin-10 signaling in lung dendritic cells by toll-like receptor 4 ligands.
Exp Lung Res. 2009 Feb;35(1):1-28.
PMID: 19191102 [PubMed - indexed for MEDLINE]
0638. Roger T, Froidevaux C, Le Roy D, Reymond MK, Chanson AL, Mauri D, Burns K, Riederer BM, Akira S, Calandra T.
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2348-52. Epub 2009 Jan 30.
PMID: 19181857 [PubMed - indexed for MEDLINE]
0637. Puliti M, Uematsu S, Akira S, Bistoni F, Tissi L.
Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease.
Infect Immun. 2009 Apr;77(4):1524-31. Epub 2009 Jan 29.
PMID: 19179417 [PubMed - indexed for MEDLINE]
0636. Dessein R, Gironella M, Vignal C, Peyrin-Biroulet L, Sokol H, Secher T, Lacas-Gervais S, Gratadoux JJ, Lafont F, Dagorn JC, Ryffel B, Akira S, Langella P, N??ez G, Sirard JC, Iovanna J, Simonet M, Chamaillard M.
TLR2 is critical for induction of REG3{beta} expression and intestinal clearance of Yersinia pseudotuberculosis.
Gut. 2009 Jun;58(6):771-776. doi:10.1136/gut.2008.168443. Epub 2009 Jan 27.
PMID: 19174417
0635. Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, Saito T.
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1897-902. Epub 2009 Jan 26.
PMID: 19171887 [PubMed - indexed for MEDLINE]
0634. Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ.
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.
Am J Physiol Renal Physiol. 2009 Apr;296(4):F867-74. Epub 2009 Jan 21.
PMID: 19158348 [PubMed - in process]
0633. Tsukamoto Y, Nagai Y, Kariyone A, Shibata T, Kaisho T, Akira S, Miyake K, Takatsu K.
Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.
Mol Immunol. 2009 Apr;46(7):1278-88. Epub 2009 Jan 20.
PMID: 19157556 [PubMed - in process]
0632. Kobiyama K, Takeshita F, Ishii KJ, Koyama S, Aoshi T, Akira S, Sakaue-Sawano A, Miyawaki A, Yamanaka Y, Hirano H, Suzuki K, Okuda K.
A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant.
J Immunol. 2009 Feb 1;182(3):1593-601.
PMID: 19155508 [PubMed - indexed for MEDLINE]
0631. Huang H, Akira S, Santos MM.
Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis?
Hepatology. 2009 Mar;49(3):1012-6.
PMID: 19152427 [PubMed - in process]
0630. Sanders CJ, Franchi L, Yarovinsky F, Uematsu S, Akira S, Nunez G, Gewirtz AT.
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity.
Eur J Immunol. 2009 Feb;39(2):359-71.
PMID: 19152336 [PubMed - indexed for MEDLINE]
0629. Kurokawa K, Lee H, Roh KB, Asanuma M, Kim YS, Nakayama H, Shiratsuchi A, Choi Y, Takeuchi O, Kang HJ, Dohmae N, Nakanishi Y, Akira S, Sekimizu K, Lee BL.
The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2.
J Biol Chem. 2009 Mar 27;284(13):8406-11. Epub 2009 Jan 12.
PMID: 19139093 [PubMed - in process]
0628. Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K.
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Nat Cell Biol. 2009 Feb;11(2):123-32. Epub 2009 Jan 11.
PMID: 19136968 [PubMed - indexed for MEDLINE]
0627. Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM, Rifkin IR.
TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.
J Immunol. 2009 Jan 15;182(2):820-8.
PMID: 19124725 [PubMed - indexed for MEDLINE]
0626. Filipovich Y, Lu SJ, Akira S, Hirsch E.
The adaptor protein MyD88 is essential for E coli-induced preterm delivery in mice.
Am J Obstet Gynecol. 2009 Jan;200(1):93.e1-8.
PMID: 19121660 [PubMed - indexed for MEDLINE]
0625. Rasmussen SB, Jensen SB, Nielsen C, Quartin E, Kato H, Chen ZJ, Silverman RH, Akira S, Paludan SR.
Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production.
J Gen Virol. 2009 Jan;90(Pt 1):74-8.
PMID: 19088275 [PubMed - indexed for MEDLINE]
0624. Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S.
The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.
Hepatology. 2009 Jan;49(1):204-14.
PMID: 19065678 [PubMed - indexed for MEDLINE]

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