0549. Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT.
Deletion of TLR5 results in spontaneous colitis in mice.
J Clin Invest. 2007 Dec;117(12):3909-21.
PMID: 18008007 [PubMed - indexed for MEDLINE]
0548. Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I.
IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
J Clin Invest. 2007 Dec;117(12):3786-99.
PMID: 17992263 [PubMed - indexed for MEDLINE]
0547. Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A, Smith KD, Skerrett SJ.
Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.
J Immunol. 2007 Nov 15;179(10):6981-7.
PMID: 17982089 [PubMed - indexed for MEDLINE]
0546. Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW.
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
J Virol. 2007 Dec;81(24):13735-42. Epub 2007 Oct 17.
PMID: 17942533 [PubMed - indexed for MEDLINE]
0545. Uematsu S, Kaisho T, Tanaka T, Matsumoto M, Yamakami M, Omori H, Yamamoto M, Yoshimori T, Akira S.
The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.
J Immunol. 2007 Oct 15;179(8):5378-86.
PMID: 17911624 [PubMed - indexed for MEDLINE]
0544. Ho LH, Ohno T, Oboki K, Kajiwara N, Suto H, Iikura M, Okayama Y, Akira S, Saito H, Galli SJ, Nakae S.
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.
J Leukoc Biol. 2007 Dec;82(6):1481-90. Epub 2007 Sep 19.
PMID: 17881510 [PubMed - indexed for MEDLINE]
0543. Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S.
Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.
J Immunol. 2007 Oct 1;179(7):4711-20.
PMID: 17878370 [PubMed - indexed for MEDLINE]
0542. Kang YJ, Kusler B, Otsuka M, Hughes M, Suzuki N, Suzuki S, Yeh WC, Akira S, Han J, Jones PP.
Calcineurin negatively regulates TLR-mediated activation pathways.
J Immunol. 2007 Oct 1;179(7):4598-607.
PMID: 17878357 [PubMed - indexed for MEDLINE]
0541. Waibler Z, Anzaghe M, Ludwig H, Akira S, Weiss S, Sutter G, Kalinke U.
Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses.
J Virol. 2007 Nov;81(22):12102-10. Epub 2007 Sep 12.
PMID: 17855554 [PubMed - indexed for MEDLINE]
0540. Biswas SK, Bist P, Dhillon MK, Kajiji T, Del Fresno C, Yamamoto M, Lopez-Collazo E, Akira S, Tergaonkar V.
Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance.
J Immunol. 2007 Sep 15;179(6):4083-92.
PMID: 17785847 [PubMed - indexed for MEDLINE]
0539. Bhan U, Lukacs NW, Osterholzer JJ, Newstead MW, Zeng X, Moore TA, McMillan TR, Krieg AM, Akira S, Standiford TJ.
TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells.
J Immunol. 2007 Sep 15;179(6):3937-46.
PMID: 17785831 [PubMed - indexed for MEDLINE]
0538. Bevelander M, Mayette J, Whittaker LA, Paveglio SA, Jones CC, Robbins J, Hemenway D, Akira S, Uematsu S, Poynter ME.
Nitrogen dioxide promotes allergic sensitization to inhaled antigen.
J Immunol. 2007 Sep 15;179(6):3680-8.
PMID: 17785804 [PubMed - indexed for MEDLINE]
0537. Zhande R, Dauphinee SM, Thomas JA, Yamamoto M, Akira S, Karsan A.
FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction.
Mol Cell Biol. 2007 Nov;27(21):7394-404. Epub 2007 Sep 4.
PMID: 17785432 [PubMed - indexed for MEDLINE]
0536. Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.
Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
J Exp Med. 2007 Sep 3;204(9):2233-9. Epub 2007 Aug 27.
PMID: 17724128 [PubMed - indexed for MEDLINE]
0535. Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa K, Kawai T, Akira S.
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Immunity. 2007 Aug;27(2):240-52.
PMID: 17723216 [PubMed - indexed for MEDLINE]
0534. Tezuka H, Abe Y, Iwata M, Takeuchi H, Ishikawa H, Matsushita M, Shiohara T, Akira S, Ohteki T.
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells.
Nature. 2007 Aug 23;448(7156):929-33.
PMID: 17713535 [PubMed - indexed for MEDLINE]
0533. Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki K, Okuda K.
The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14050-5. Epub 2007 Aug 20.
PMID: 17709747 [PubMed - indexed for MEDLINE]
0532. Kim HS, Han MS, Chung KW, Kim S, Kim E, Kim MJ, Jang E, Lee HA, Youn J, Akira S, Lee MS.
Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes.
Immunity. 2007 Aug;27(2):321-33. Epub 2007 Aug 16.
PMID: 17707128 [PubMed - indexed for MEDLINE]
0531. Sakamori R, Takehara T, Ohnishi C, Tatsumi T, Ohkawa K, Takeda K, Akira S, Hayashi N.
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice.
Hepatology. 2007 Nov;46(5):1564-73.
PMID: 17705264 [PubMed - indexed for MEDLINE]
0530. Li J, Song W, Czerwinski DK, Varghese B, Uematsu S, Akira S, Krieg AM, Levy R.
Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.
J Immunol. 2007 Aug 15;179(4):2493-500.
PMID: 17675511 [PubMed - indexed for MEDLINE]
0529. Lang KS, Navarini AA, Recher M, Lang PA, Heikenwalder M, Stecher B, Bergthaler A, Odermatt B, Akira S, Honda K, Hengartner H, Zinkernagel RM.
MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus.
Eur J Immunol. 2007 Sep;37(9):2434-40.
PMID: 17668900 [PubMed - indexed for MEDLINE]
0528. Han JH, Akira S, Calame K, Beutler B, Selsing E, Imanishi-Kari T.
Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.
Immunity. 2007 Jul;27(1):64-75. Epub 2007 Jul 19.
PMID: 17658280 [PubMed - indexed for MEDLINE]
0527. Kuroda E, Noguchi J, Doi T, Uematsu S, Akira S, Yamashita U.
IL-3 is an important differentiation factor for the development of prostaglandin E2-producing macrophages between C57BL/6 and BALB/c mice.
Eur J Immunol. 2007 Aug;37(8):2185-95.
PMID: 17628861 [PubMed - indexed for MEDLINE]
0526. Saha S, Takeshita F, Matsuda T, Jounai N, Kobiyama K, Matsumoto T, Sasaki S, Yoshida A, Xin KQ, Klinman DM, Uematsu S, Ishii KJ, Akira S, Okuda K.
Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.
J Immunol. 2007 Jul 15;179(2):1147-54.
PMID: 17617608 [PubMed - indexed for MEDLINE]
0525. Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A.
ER stress triggers apoptosis by activating BH3-only protein Bim.
Cell. 2007 Jun 29;129(7):1337-49.
PMID: 17604722 [PubMed - indexed for MEDLINE]
0524. Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dotsch V, Dikic I.
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
EMBO J. 2007 Jul 25;26(14):3451-62. Epub 2007 Jun 28.
PMID: 17599067 [PubMed - indexed for MEDLINE]
0523. Chen CJ, Kono H, Golenbock D, Reed G, Akira S, Rock KL.
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
Nat Med. 2007 Jul;13(7):851-6. Epub 2007 Jun 17.
PMID: 17572686 [PubMed - indexed for MEDLINE]
0522. Abe T, Kaname Y, Hamamoto I, Tsuda Y, Wen X, Taguwa S, Moriishi K, Takeuchi O, Kawai T, Kanto T, Hayashi N, Akira S, Matsuura Y.
Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines.
J Virol. 2007 Sep;81(17):8953-66. Epub 2007 Jun 13.
PMID: 17567694 [PubMed - indexed for MEDLINE]
0521. Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira S, Savan R, van Echo D, Fitzgerald KA, Young HA, Ching LM, Vogel SN.
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
J Exp Med. 2007 Jul 9;204(7):1559-69. Epub 2007 Jun 11.
PMID: 17562815 [PubMed - indexed for MEDLINE]
0520. Shimada N, Coban C, Takeda Y, Mizu M, Minari J, Anada T, Torii Y, Shinkai S, Akira S, Ishii KJ, Sakurai K.
A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells.
Bioconjug Chem. 2007 Jul-Aug;18(4):1280-6. Epub 2007 May 27.
PMID: 17530815 [PubMed - indexed for MEDLINE]
0519. Bobacz K, Sunk IG, Hofstaetter JG, Amoyo L, Toma CD, Akira S, Weichhart T, Saemann M, Smolen JS.
Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7.
Arthritis Rheum. 2007 Jun;56(6):1880-93.
PMID: 17530716 [PubMed - indexed for MEDLINE]
0518. Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR.
Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.
J Immunol. 2007 Jun 1;178(11):6876-85.
PMID: 17513736 [PubMed - indexed for MEDLINE]
0517. Imanishi T, Hara H, Suzuki S, Suzuki N, Akira S, Saito T.
Cutting edge: TLR2 directly triggers Th1 effector functions.
J Immunol. 2007 Jun 1;178(11):6715-9.
PMID: 17513716 [PubMed - indexed for MEDLINE]
0516. Shim DH, Chang SY, Park SM, Jang H, Carbis R, Czerkinsky C, Uematsu S, Akira S, Kweon MN.
Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a.
Vaccine. 2007 Jun 15;25(25):4828-36. Epub 2007 Apr 20.
PMID: 17507120 [PubMed - indexed for MEDLINE]
0515. Ramesh G, Zhang B, Uematsu S, Akira S, Reeves WB.
Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.
Am J Physiol Renal Physiol. 2007 Jul;293(1):F325-32. Epub 2007 May 9.
PMID: 17494092 [PubMed - indexed for MEDLINE]
0514. Cook P, Totemeyer S, Stevenson C, Fitzgerald KA, Yamamoto M, Akira S, Maskell DJ, Bryant CE.
Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
Immunology. 2007 Oct;122(2):222-9. Epub 2007 May 9.
PMID: 17490432 [PubMed - indexed for MEDLINE]
0513. Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira S.
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.
J Exp Med. 2007 May 14;204(5):1013-24. Epub 2007 May 7.
PMID: 17485511 [PubMed - indexed for MEDLINE]
0512. Andersen-Nissen E, Hawn TR, Smith KD, Nachman A, Lampano AE, Uematsu S, Akira S, Aderem A.
Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.
J Immunol. 2007 Apr 15;178(8):4717-20.
PMID: 17404249 [PubMed - indexed for MEDLINE]
0511. Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU.
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
Nature. 2007 Apr 19;446(7138):916-920.
PMID: 17392790 [PubMed - indexed for MEDLINE]
0510. Miggin SM, Palsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, Murphy C, Moynagh P, Yamamoto M, Akira S, Rothwell N, Golenbock D, Fitzgerald KA, O'Neill LA.
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3372-7. Epub 2007 Feb 20.
PMID: 17360653 [PubMed - indexed for MEDLINE]
0509. Kim D, Kim MA, Cho IH, Kim MS, Lee S, Jo EK, Choi SY, Park K, Kim JS, Akira S, Na HS, Oh SB, Lee SJ.
A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity.
J Biol Chem. 2007 May 18;282(20):14975-83. Epub 2007 Mar 13.
PMID: 17355971 [PubMed - indexed for MEDLINE]
0508. Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney DG.
Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori.
Infect Immun. 2007 May;75(5):2408-14. Epub 2007 Mar 12.
PMID: 17353291 [PubMed - indexed for MEDLINE]
0507. Tao K, Fujii M, Tsukumo S, Maekawa Y, Kishihara K, Kimoto Y, Horiuchi T, Hisaeda H, Akira S, Kagami S, Yasutomo K.
Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population.
Ann Rheum Dis. 2007 Jul;66(7):905-9. Epub 2007 Mar 7.
PMID: 17344245 [PubMed - indexed for MEDLINE]
0506. Alugupalli KR, Akira S, Lien E, Leong JM.
MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.
J Immunol. 2007 Mar 15;178(6):3740-9.
PMID: 17339472 [PubMed - indexed for MEDLINE]
0505. Power MR, Li B, Yamamoto M, Akira S, Lin TJ.
A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-beta in the host response to Pseudomonas aeruginosa lung infection in mice.
J Immunol. 2007 Mar 1;178(5):3170-6.
PMID: 17312165 [PubMed - indexed for MEDLINE]
0504. Jeyaseelan S, Young SK, Fessler MB, Liu Y, Malcolm KC, Yamamoto M, Akira S, Worthen GS.
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia.
J Immunol. 2007 Mar 1;178(5):3153-60.
PMID: 17312163 [PubMed - indexed for MEDLINE]
0503. Hamm S, Heit A, Koffler M, Huster KM, Akira S, Busch DH, Wagner H, Bauer S.
Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.
Int Immunol. 2007 Mar;19(3):297-304. Epub 2007 Feb 7.
PMID: 17289655 [PubMed - indexed for MEDLINE]
0502. Sawaki J, Tsutsui H, Hayashi N, Yasuda K, Akira S, Tanizawa T, Nakanishi K.
Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways.
Int Immunol. 2007 Mar;19(3):311-20. Epub 2007 Feb 7.
PMID: 17289654 [PubMed - indexed for MEDLINE]
0501. Heer AK, Shamshiev A, Donda A, Uematsu S, Akira S, Kopf M, Marsland BJ.
TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses.
J Immunol. 2007 Feb 15;178(4):2182-91.
PMID: 17277123 [PubMed - indexed for MEDLINE]
0500. Qiao H, Sonoda KH, Ikeda Y, Yoshimura T, Hijioka K, Jo YJ, Sassa Y, Tsutsumi-Miyahara C, Hata Y, Akira S, Ishibashi T.
Interleukin-18 regulates pathological intraocular neovascularization.
J Leukoc Biol. 2007 Apr;81(4):1012-21. Epub 2007 Jan 18.
PMID: 17234681 [PubMed - indexed for MEDLINE]
0499. Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H, Fujita T.
Viral infections activate types I and III interferon genes through a common mechanism.
J Biol Chem. 2007 Mar 9;282(10):7576-81. Epub 2007 Jan 4.
PMID: 17204473 [PubMed - indexed for MEDLINE]
0498. Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X.
Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification.
J Biol Chem. 2007 Mar 2;282(9):6075-89. Epub 2006 Dec 29.
PMID: 17197697 [PubMed - indexed for MEDLINE]
0497. Saito T, Hirai R, Loo YM, Owen D, Johnson CL, Sinha SC, Akira S, Fujita T, Gale M Jr.
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):582-7. Epub 2006 Dec 26.
PMID: 17190814 [PubMed - indexed for MEDLINE]
0496. Dessing MC, van der Sluijs KF, Florquin S, Akira S, van der Poll T.
Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia.
Am J Respir Cell Mol Biol. 2007 May;36(5):609-14. Epub 2006 Dec 14.
PMID: 17170383 [PubMed - indexed for MEDLINE]
0495. Saijo S, Fujikado N, Furuta T, Chung SH, Kotaki H, Seki K, Sudo K, Akira S, Adachi Y, Ohno N, Kinjo T, Nakamura K, Kawakami K, Iwakura Y.
Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.
Nat Immunol. 2007 Jan;8(1):39-46. Epub 2006 Dec 10.
PMID: 17159982 [PubMed - indexed for MEDLINE]
0494. Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S.
Pathological role of Toll-like receptor signaling in cerebral malaria.
Int Immunol. 2007 Jan;19(1):67-79. Epub 2006 Nov 29.
PMID: 17135446 [PubMed - indexed for MEDLINE]
0493. Albiger B, Dahlberg S, Sandgren A, Wartha F, Beiter K, Katsuragi H, Akira S, Normark S, Henriques-Normark B.
Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.
Cell Microbiol. 2007 Mar;9(3):633-44. Epub 2006 Sep 27.
PMID: 17004992 [PubMed - indexed for MEDLINE]
0492. Cervantes-Barragan L, Zust R, Weber F, Spiegel M, Lang KS, Akira S, Thiel V, Ludewig B.
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
Blood. 2007 Feb 1;109(3):1131-7. Epub 2006 Sep 19.
PMID: 16985170 [PubMed - indexed for MEDLINE]
0491. Sakata Y, Dong JW, Vallejo JG, Huang CH, Baker JS, Tracey KJ, Tacheuchi O, Akira S, Mann DL.
Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury.
Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H503-9. Epub 2006 Sep 15.
PMID: 16980352 [PubMed - indexed for MEDLINE]
0490. Yang CS, Lee JS, Song CH, Hur GM, Lee SJ, Tanaka S, Akira S, Paik TH, Jo EK.
Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.
Cell Microbiol. 2007 Feb;9(2):382-96. Epub 2006 Aug 22.
PMID: 16925784 [PubMed - indexed for MEDLINE]

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