0489. Busconi L, Lau CM, Tabor AS, Uccellini MB, Ruhe Z, Akira S, Viglianti GA, Rifkin IR, Marshak-Rothstein A.
DNA and RNA autoantigens as autoadjuvants.
J Endotoxin Res. 2006;12(6):379-84.
PMID: 17254393 [PubMed - indexed for MEDLINE]
0488. Samarasinghe R, Tailor P, Tamura T, Kaisho T, Akira S, Ozato K.
Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling.
J Interferon Cytokine Res. 2006 Dec;26(12):893-900.
PMID: 17238832 [PubMed - indexed for MEDLINE]
0487. Harada M, Magara-Koyanagi K, Watarai H, Nagata Y, Ishii Y, Kojo S, Horiguchi S, Okamoto Y, Nakayama T, Suzuki N, Yeh WC, Akira S, Kitamura H, Ohara O, Seino K, Taniguchi M.
IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses.
J Exp Med. 2006 Dec 25;203(13):2929-37. Epub 2006 Dec 18.
PMID: 17178921 [PubMed - indexed for MEDLINE]
0486. Choo MK, Kawasaki N, Singhirunnusorn P, Koizumi K, Sato S, Akira S, Saiki I, Sakurai H.
Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.
Mol Cancer Ther. 2006 Dec;5(12):2970-6.
PMID: 17172402 [PubMed - indexed for MEDLINE]
0485. Boonstra A, Rajsbaum R, Holman M, Marques R, Asselin-Paturel C, Pereira JP, Bates EE, Akira S, Vieira P, Liu YJ, Trinchieri G, O'Garra A.
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
J Immunol. 2006 Dec 1;177(11):7551-8.
PMID: 17114424 [PubMed - indexed for MEDLINE]
0484. Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S.
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
J Immunol. 2006 Dec 1;177(11):7520-4.
PMID: 17114420 [PubMed - indexed for MEDLINE]
0483. Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Reis e Sousa C.
Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides.
Eur J Immunol. 2006 Dec;36(12):3256-67.
PMID: 17111347 [PubMed - indexed for MEDLINE]
0482. Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S, Iwakura Y, Cua DJ, Takayanagi H.
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.
J Exp Med. 2006 Nov 27;203(12):2673-82. Epub 2006 Nov 6.
PMID: 17088434 [PubMed - indexed for MEDLINE]
0481. Koga R, Hamano S, Kuwata H, Atarashi K, Ogawa M, Hisaeda H, Yamamoto M, Akira S, Himeno K, Matsumoto M, Takeda K.
TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi.
J Immunol. 2006 Nov 15;177(10):7059-66.
PMID: 17082622 [PubMed - indexed for MEDLINE]
0480. Matsui K, Kumagai Y, Kato H, Sato S, Kawagoe T, Uematsu S, Takeuchi O, Akira S.
Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.
J Immunol. 2006 Nov 1;177(9):5785-9.
PMID: 17056502 [PubMed - indexed for MEDLINE]
0479. Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G.
5'-Triphosphate RNA is the ligand for RIG-I.
Science. 2006 Nov 10;314(5801):994-7. Epub 2006 Oct 12.
PMID: 17038590 [PubMed - indexed for MEDLINE]
0478. Furuta T, Kikuchi T, Akira S, Watanabe N, Yoshikawa Y.
Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis.
Int Immunol. 2006 Dec;18(12):1655-62. Epub 2006 Oct 11.
PMID: 17035347 [PubMed - indexed for MEDLINE]
0477. Power MR, Marshall JS, Yamamoto M, Akira S, Lin TJ.
The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice.
Clin Exp Immunol. 2006 Nov;146(2):323-9.
PMID: 17034585 [PubMed - indexed for MEDLINE]
0476. Bolz DD, Sundsbak RS, Ma Y, Akira S, Weis JH, Schwan TG, Weis JJ.
Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.
Infect Immun. 2006 Dec;74(12):6750-60. Epub 2006 Oct 9.
PMID: 17030581 [PubMed - indexed for MEDLINE]
0475. Amer A, Franchi L, Kanneganti TD, Body-Malapel M, Ozoren N, Brady G, Meshinchi S, Jagirdar R, Gewirtz A, Akira S, Nunez G.
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.
J Biol Chem. 2006 Nov 17;281(46):35217-23. Epub 2006 Sep 19.
PMID: 16984919 [PubMed - indexed for MEDLINE]
0474. Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S.
VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.
J Biol Chem. 2006 Dec 1;281(48):36897-904. Epub 2006 Sep 19.
PMID: 16984916 [PubMed - indexed for MEDLINE]
0473. Shimada N, Ishii KJ, Takeda Y, Coban C, Torii Y, Shinkai S, Akira S, Sakurai K.
Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier.
Bioconjug Chem. 2006 Sep-Oct;17(5):1136-40.
PMID: 16984120 [PubMed - indexed for MEDLINE]
0472. Togbe D, Aurore G, Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Vasseur V, Akira S, Hoebe K, Beutler B, Ryffel B, Couillin I.
Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways.
Lab Invest. 2006 Nov;86(11):1126-35. Epub 2006 Sep 18.
PMID: 16983331 [PubMed - indexed for MEDLINE]
0471. Montminy SW, Khan N, McGrath S, Walkowicz MJ, Sharp F, Conlon JE, Fukase K, Kusumoto S, Sweet C, Miyake K, Akira S, Cotter RJ, Goguen JD, Lien E.
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response.
Nat Immunol. 2006 Oct;7(10):1066-73. Epub 2006 Sep 17.
PMID: 16980981 [PubMed - indexed for MEDLINE]
0470. Berland R, Fernandez L, Kari E, Han JH, Lomakin I, Akira S, Wortis HH, Kearney JF, Ucci AA, Imanishi-Kari T.
Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice.
Immunity. 2006 Sep;25(3):429-40.
PMID: 16973388 [PubMed - indexed for MEDLINE]
0469. Chen L, Wang T, Zhou P, Ma L, Yin D, Shen J, Molinero L, Nozaki T, Phillips T, Uematsu S, Akira S, Wang CR, Fairchild RL, Alegre ML, Chong A.
TLR engagement prevents transplantation tolerance.
Am J Transplant. 2006 Oct;6(10):2282-91.
PMID: 16970798 [PubMed - indexed for MEDLINE]
0468. Lang KS, Georgiev P, Recher M, Navarini AA, Bergthaler A, Heikenwalder M, Harris NL, Junt T, Odermatt B, Clavien PA, Pircher H, Akira S, Hengartner H, Zinkernagel RM.
Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.
J Clin Invest. 2006 Sep;116(9):2456-63.
PMID: 16955143 [PubMed - indexed for MEDLINE]
0467. Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S.
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
Int Immunol. 2006 Oct;18(10):1405-11. Epub 2006 Aug 28.
PMID: 16940043 [PubMed - indexed for MEDLINE]
0466. Kamon H, Kawabe T, Kitamura H, Lee J, Kamimura D, Kaisho T, Akira S, Iwamatsu A, Koga H, Murakami M, Hirano T.
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation.
EMBO J. 2006 Sep 6;25(17):4108-19. Epub 2006 Aug 17.
PMID: 16917499 [PubMed - indexed for MEDLINE]
0465. Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J.
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.
J Biol Chem. 2006 Sep 29;281(39):28802-10. Epub 2006 Aug 7.
PMID: 16893890 [PubMed - indexed for MEDLINE]
0464. Kitamura H, Morikawa H, Kamon H, Iguchi M, Hojyo S, Fukada T, Yamashita S, Kaisho T, Akira S, Murakami M, Hirano T.
Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.
Nat Immunol. 2006 Sep;7(9):971-7. Epub 2006 Aug 6.
PMID: 16892068 [PubMed - indexed for MEDLINE]
0463. Kim L, Butcher BA, Lee CW, Uematsu S, Akira S, Denkers EY.
Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages.
J Immunol. 2006 Aug 15;177(4):2584-91.
PMID: 16888020 [PubMed - indexed for MEDLINE]
0462. Chen CJ, Shi Y, Hearn A, Fitzgerald K, Golenbock D, Reed G, Akira S, Rock KL.
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
J Clin Invest. 2006 Aug;116(8):2262-71.
PMID: 16886064 [PubMed - indexed for MEDLINE]
0461. Wuest T, Austin BA, Uematsu S, Thapa M, Akira S, Carr DJ.
Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10.
J Neuroimmunol. 2006 Oct;179(1-2):46-52. Epub 2006 Aug 1.
PMID: 16884784 [PubMed - indexed for MEDLINE]
0460. Shirakawa K, Maeda S, Gotoh T, Hayashi M, Shinomiya K, Ehata S, Nishimura R, Mori M, Onozaki K, Hayashi H, Uematsu S, Akira S, Ogata E, Miyazono K, Imamura T.
CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation.
Mol Cell Biol. 2006 Aug;26(16):6105-16.
PMID: 16880521 [PubMed - indexed for MEDLINE]
0459. Ikeda-Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y.
Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11790-5. Epub 2006 Jul 24.
PMID: 16864802 [PubMed - indexed for MEDLINE]
0458. Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Nat Immunol. 2006 Sep;7(9):962-70. Epub 2006 Jul 23.
PMID: 16862162 [PubMed - indexed for MEDLINE]
0457. Inada M, Matsumoto C, Uematsu S, Akira S, Miyaura C.
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.
J Immunol. 2006 Aug 1;177(3):1879-85.
PMID: 16849500 [PubMed - indexed for MEDLINE]
0456. Bai T, Tanaka T, Yukawa K, Umesaki N, Matsumoto M, Akira S.
Impaired postnatal development in C/EBPbeta-deficient mice.
J Reprod Dev. 2006 Oct;52(5):645-9. Epub 2006 Jul 13.
PMID: 16837772 [PubMed - indexed for MEDLINE]
0455. Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S.
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
Nat Immunol. 2006 Aug;7(8):868-74. Epub 2006 Jul 9.
PMID: 16829963 [PubMed - indexed for MEDLINE]
0454. Fink K, Lang KS, Manjarrez-Orduno N, Junt T, Senn BM, Holdener M, Akira S, Zinkernagel RM, Hengartner H.
Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.
Eur J Immunol. 2006 Aug;36(8):2094-105.
PMID: 16810635 [PubMed - indexed for MEDLINE]
0453. Behera AK, Hildebrand E, Uematsu S, Akira S, Coburn J, Hu LT.
Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1.
J Immunol. 2006 Jul 1;177(1):657-64.
PMID: 16785564 [PubMed - indexed for MEDLINE]
0452. Jeyaseelan S, Young SK, Yamamoto M, Arndt PG, Akira S, Kolls JK, Worthen GS.
Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa.
J Immunol. 2006 Jul 1;177(1):538-47.
PMID: 16785551 [PubMed - indexed for MEDLINE]
0451. Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S.
Essential role of IPS-1 in innate immune responses against RNA viruses.
J Exp Med. 2006 Jul 10;203(7):1795-803. Epub 2006 Jun 19.
PMID: 16785313 [PubMed - indexed for MEDLINE]
0450. Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takatsu K, Kincade PW.
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Immunity. 2006 Jun;24(6):801-12.
PMID: 16782035 [PubMed - indexed for MEDLINE]
0449. Takeshita F, Tanaka T, Matsuda T, Tozuka M, Kobiyama K, Saha S, Matsui K, Ishii KJ, Coban C, Akira S, Ishii N, Suzuki K, Klinman DM, Okuda K, Sasaki S.
Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity.
J Virol. 2006 Jul;80(13):6218-24.
PMID: 16775309 [PubMed - indexed for MEDLINE]
0448. Cottalorda A, Verschelde C, Marcais A, Tomkowiak M, Musette P, Uematsu S, Akira S, Marvel J, Bonnefoy-Berard N.
TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation.
Eur J Immunol. 2006 Jul;36(7):1684-93.
PMID: 16761317 [PubMed - indexed for MEDLINE]
0447. Takahashi Y, Isuzugawa K, Murase Y, Imai M, Yamamoto S, Iizuka M, Akira S, Bahr GM, Momotani E, Hori M, Ozaki H, Imakawa K.
Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages.
J Vet Med Sci. 2006 May;68(5):471-8.
PMID: 16757890 [PubMed - indexed for MEDLINE]
0446. Miyatsuka T, Kaneto H, Shiraiwa T, Matsuoka TA, Yamamoto K, Kato K, Nakamura Y, Akira S, Takeda K, Kajimoto Y, Yamasaki Y, Sandgren EP, Kawaguchi Y, Wright CV, Fujitani Y.
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.
Genes Dev. 2006 Jun 1;20(11):1435-40.
PMID: 16751181 [PubMed - indexed for MEDLINE]
0445. Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X.
TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent.
J Biol Chem. 2006 Jul 28;281(30):21013-21. Epub 2006 May 31.
PMID: 16737960 [PubMed - indexed for MEDLINE]
0444. Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ, Tack CJ, van Krieken H, Kim SH, Stalenhoef AF, van de Loo FA, Verschueren I, Pulawa L, Akira S, Eckel RH, Dinarello CA, van den Berg W, van der Meer JW.
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Nat Med. 2006 Jun;12(6):650-6. Epub 2006 May 28.
PMID: 16732281 [PubMed - indexed for MEDLINE]
0443. Yoshimatsu T, Kawaguchi D, Oishi K, Takeda K, Akira S, Masuyama N, Gotoh Y.
Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex.
Development. 2006 Jul;133(13):2553-63. Epub 2006 May 25.
PMID: 16728475 [PubMed - indexed for MEDLINE]
0442. Takegahara N, Takamatsu H, Toyofuku T, Tsujimura T, Okuno T, Yukawa K, Mizui M, Yamamoto M, Prasad DV, Suzuki K, Ishii M, Terai K, Moriya M, Nakatsuji Y, Sakoda S, Sato S, Akira S, Takeda K, Inui M, Takai T, Ikawa M, Okabe M, Kumanogoh A, Kikutani H.
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
Nat Cell Biol. 2006 Jun;8(6):615-22. Epub 2006 May 21.
PMID: 16715077 [PubMed - indexed for MEDLINE]
0441. Nakamura K, Miyagi K, Koguchi Y, Kinjo Y, Uezu K, Kinjo T, Akamine M, Fujita J, Kawamura I, Mitsuyama M, Adachi Y, Ohno N, Takeda K, Akira S, Miyazato A, Kaku M, Kawakami K.
Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans.
FEMS Immunol Med Microbiol. 2006 Jun;47(1):148-54.
PMID: 16706798 [PubMed - indexed for MEDLINE]
0440. Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu KP, Yamaoka S.
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.
Nat Immunol. 2006 Jun;7(6):598-605. Epub 2006 May 14.
PMID: 16699525 [PubMed - indexed for MEDLINE]
0439. Sumikawa Y, Asada H, Hoshino K, Azukizawa H, Katayama I, Akira S, Itami S.
Induction of beta-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2.
Microbes Infect. 2006 May;8(6):1513-21. Epub 2006 Apr 7.
PMID: 16697678 [PubMed - indexed for MEDLINE]
0438. Schellack C, Prinz K, Egyed A, Fritz JH, Wittmann B, Ginzler M, Swatosch G, Zauner W, Kast C, Akira S, von Gabain A, Buschle M, Lingnau K.
IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses.
Vaccine. 2006 Jun 29;24(26):5461-72. Epub 2006 Apr 7.
PMID: 16678312 [PubMed - indexed for MEDLINE]
0437. Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart RC, Ninomiya-Tsuji J.
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis.
J Biol Chem. 2006 Jul 14;281(28):19610-7. Epub 2006 May 4.
PMID: 16675448 [PubMed - indexed for MEDLINE]
0436. Endo M, Mori M, Akira S, Gotoh T.
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.
J Immunol. 2006 May 15;176(10):6245-53.
PMID: 16670335 [PubMed - indexed for MEDLINE]
0435. Kelly KM, Zhuang H, Nacionales DC, Scumpia PO, Lyons R, Akaogi J, Lee P, Williams B, Yamamoto M, Akira S, Satoh M, Reeves WH.
Endogenous adjuvant activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.
Arthritis Rheum. 2006 May;54(5):1557-67.
PMID: 16645989 [PubMed - indexed for MEDLINE]
0434. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S.
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Nature. 2006 May 4;441(7089):101-5. Epub 2006 Apr 9.
PMID: 16625202 [PubMed - indexed for MEDLINE]
0433. Loseke S, Grage-Griebenow E, Heine H, Wagner A, Akira S, Bauer S, Bufe A.
In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells.
Scand J Immunol. 2006 Apr;63(4):264-74.
PMID: 16623926 [PubMed - indexed for MEDLINE]
0432. Barrier M, Lacroix-Lamande S, Mancassola R, Auray G, Bernardet N, Chausse AM, Uematsu S, Akira S, Laurent F.
Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice.
J Infect Dis. 2006 May 15;193(10):1400-7. Epub 2006 Apr 10.
PMID: 16619188 [PubMed - indexed for MEDLINE]
0431. Hoshino K, Sugiyama T, Matsumoto M, Tanaka T, Saito M, Hemmi H, Ohara O, Akira S, Kaisho T.
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.
Nature. 2006 Apr 13;440(7086):949-53.
PMID: 16612387 [PubMed - indexed for MEDLINE]
0430. Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT.
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6299-304. Epub 2006 Apr 7.
PMID: 16603631 [PubMed - indexed for MEDLINE]
0429. Yukawa K, Tanaka T, Bai T, Li L, Tsubota Y, Owada-Makabe K, Maeda M, Hoshino K, Akira S, Iso H.
Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice.
Int J Mol Med. 2006 May;17(5):869-73.
PMID: 16596273 [PubMed - indexed for MEDLINE]
0428. Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S.
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA.
J Immunol. 2006 Apr 15;176(8):4520-4.
PMID: 16585540 [PubMed - indexed for MEDLINE]
0427. Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara K, Katayose K, Okamura H, Kahn CR, Noda T, Takeda K, Akira S, Inui A, Kasuga M.
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Cell Metab. 2006 Apr;3(4):267-75.
PMID: 16581004 [PubMed - indexed for MEDLINE]
0426. Kinoshita D, Hirota F, Kaisho T, Kasai M, Izumi K, Bando Y, Mouri Y, Matsushima A, Niki S, Han H, Oshikawa K, Kuroda N, Maegawa M, Irahara M, Takeda K, Akira S, Matsumoto M.
Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.
J Immunol. 2006 Apr 1;176(7):3995-4002.
PMID: 16547234 [PubMed - indexed for MEDLINE]
0425. Oshikawa T, Okamoto M, Tano T, Sasai A, Kan S, Moriya Y, Ryoma Y, Saito M, Akira S, Sato M.
Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.
J Immunother. 2006 Mar-Apr;29(2):143-50.
PMID: 16531815 [PubMed - indexed for MEDLINE]
0424. Rumio C, Besusso D, Arnaboldi F, Palazzo M, Selleri S, Gariboldi S, Akira S, Uematsu S, Bignami P, Ceriani V, Menard S, Balsari A.
Activation of smooth muscle and myenteric plexus cells of jejunum via Toll-like receptor 4.
J Cell Physiol. 2006 Jul;208(1):47-54.
PMID: 16523497 [PubMed - indexed for MEDLINE]
0423. Santos LL, Milenkovski GP, Hall PH, Leech M, Sharma L, Takeda K, Akira S, Kitching AR, Morand EF.
IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis.
Immunol Cell Biol. 2006 Apr;84(2):166-73.
PMID: 16519734 [PubMed - indexed for MEDLINE]
0422. Bhattacharjee RN, Akira S.
Modifying toll-like receptor 9 signaling for therapeutic use.
Mini Rev Med Chem. 2006 Mar;6(3):287-91.
PMID: 16515467 [PubMed - indexed for MEDLINE]
0421. Behera AK, Hildebrand E, Bronson RT, Perides G, Uematsu S, Akira S, Hu LT.
MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi.
Infect Immun. 2006 Mar;74(3):1462-70.
PMID: 16495516 [PubMed - indexed for MEDLINE]
0420. Zhu P, Baek SH, Bourk EM, Ohgi KA, Garcia-Bassets I, Sanjo H, Akira S, Kotol PF, Glass CK, Rosenfeld MG, Rose DW.
Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.
Cell. 2006 Feb 10;124(3):615-29.
PMID: 16469706 [PubMed - indexed for MEDLINE]
0419. Lapaque N, Takeuchi O, Corrales F, Akira S, Moriyon I, Howard JC, Gorvel JP.
Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.
Cell Microbiol. 2006 Mar;8(3):401-13.
PMID: 16469053 [PubMed - indexed for MEDLINE]
0418. Querec T, Bennouna S, Alkan S, Laouar Y, Gorden K, Flavell R, Akira S, Ahmed R, Pulendran B.
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity.
J Exp Med. 2006 Feb 20;203(2):413-24. Epub 2006 Feb 6.
PMID: 16461338 [PubMed - indexed for MEDLINE]
0417. Buwitt-Beckmann U, Heine H, Wiesmuller KH, Jung G, Brock R, Akira S, Ulmer AJ.
TLR1- and TLR6-independent recognition of bacterial lipopeptides.
J Biol Chem. 2006 Apr 7;281(14):9049-57. Epub 2006 Feb 2.
PMID: 16455646 [PubMed - indexed for MEDLINE]
0416. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J.
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
J Biol Chem. 2006 Mar 24;281(12):7863-72. Epub 2006 Jan 30.
PMID: 16446357 [PubMed - indexed for MEDLINE]
0415. Sutmuller RP, den Brok MH, Kramer M, Bennink EJ, Toonen LW, Kullberg BJ, Joosten LA, Akira S, Netea MG, Adema GJ.
Toll-like receptor 2 controls expansion and function of regulatory T cells.
J Clin Invest. 2006 Feb;116(2):485-94. Epub 2006 Jan 19.
PMID: 16424940 [PubMed - indexed for MEDLINE]
0414. Kiura K, Kataoka H, Nakata T, Into T, Yasuda M, Akira S, Inoue N, Shibata K.
The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through Toll-like receptor 2.
FEMS Immunol Med Microbiol. 2006 Feb;46(1):78-84.
PMID: 16420600 [PubMed - indexed for MEDLINE]
0413. Kanneganti TD, Ozoren N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Nunez G.
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
Nature. 2006 Mar 9;440(7081):233-6. Epub 2006 Jan 11.
PMID: 16407888 [PubMed - indexed for MEDLINE]
0412. Suram S, Brown GD, Ghosh M, Gordon S, Loper R, Taylor PR, Akira S, Uematsu S, Williams DL, Leslie CC.
Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor.
J Biol Chem. 2006 Mar 3;281(9):5506-14. Epub 2006 Jan 3.
PMID: 16407295 [PubMed - indexed for MEDLINE]
0411. Marty RR, Dirnhofer S, Mauermann N, Schweikert S, Akira S, Hunziker L, Penninger JM, Eriksson U.
MyD88 signaling controls autoimmune myocarditis induction.
Circulation. 2006 Jan 17;113(2):258-65. Epub 2006 Jan 9.
PMID: 16401773 [PubMed - indexed for MEDLINE]
0410. Fischer H, Yamamoto M, Akira S, Beutler B, Svanborg C.
Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection.
Eur J Immunol. 2006 Feb;36(2):267-77.
PMID: 16385628 [PubMed - indexed for MEDLINE]
0409. Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z.
BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway.
Mol Cell Biol. 2006 Jan;26(2):448-56.
PMID: 16382137 [PubMed - indexed for MEDLINE]
0408. Rogers KA, Rogers AB, Leav BA, Sanchez A, Vannier E, Uematsu S, Akira S, Golenbock D, Ward HD.
MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice.
Infect Immun. 2006 Jan;74(1):549-56.
PMID: 16369011 [PubMed - indexed for MEDLINE]
0407. Sekine Y, Yumioka T, Yamamoto T, Muromoto R, Imoto S, Sugiyma K, Oritani K, Shimoda K, Minoguchi M, Akira S, Yoshimura A, Matsuda T.
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
J Immunol. 2006 Jan 1;176(1):380-9.
PMID: 16365431 [PubMed - indexed for MEDLINE]
0406. Sato N, Kamada N, Muromoto R, Kawai T, Sugiyama K, Watanabe T, Imoto S, Sekine Y, Ohbayashi N, Ishida M, Akira S, Matsuda T.
Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.
Immunol Lett. 2006 Mar 15;103(2):127-34. Epub 2005 Nov 9.
PMID: 16325270 [PubMed - indexed for MEDLINE]
0405. Wingender G, Garbi N, Schumak B, Jungerkes F, Endl E, von Bubnoff D, Steitz J, Striegler J, Moldenhauer G, Tuting T, Heit A, Huster KM, Takikawa O, Akira S, Busch DH, Wagner H, Hammerling GJ, Knolle PA, Limmer A.
Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.
Eur J Immunol. 2006 Jan;36(1):12-20.
PMID: 16323249 [PubMed - indexed for MEDLINE]
0404. Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S.
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Nat Immunol. 2006 Jan;7(1):40-8. Epub 2005 Nov 13. Erratum in: Nat Immunol. 2006 Apr;7(4):427.
PMID: 16286919 [PubMed - indexed for MEDLINE]
0403. Knapp S, Wieland CW, Florquin S, Pantophlet R, Dijkshoorn L, Tshimbalanga N, Akira S, van der Poll T.
Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia.
Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9. Epub 2005 Oct 6.
PMID: 16210672 [PubMed - indexed for MEDLINE]
0402. Ogawa A, Tagawa T, Nishimura H, Yajima T, Abe T, Arai T, Taniguchi M, Takeda K, Akira S, Nimura Y, Yoshikai Y.
Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice.
Gut. 2006 Jan;55(1):105-13. Epub 2005 Aug 23.
PMID: 16118350 [PubMed - indexed for MEDLINE]

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