0401. Savarese E, Chae OW, Trowitzsch S, Weber G, Kastner B, Akira S, Wagner H, Schmid RM, Bauer S, Krug A.
U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.
Blood. 2006 Apr 15;107(8):3229-34. Epub 2005 Dec 20. Erratum in: Blood. 2006 May 15;107(10):3831.
PMID: 16368889 [PubMed - indexed for MEDLINE]
0400. Vollmer J, Tluk S, Schmitz C, Hamm S, Jurk M, Forsbach A, Akira S, Kelly KM, Reeves WH, Bauer S, Krieg AM.
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.
J Exp Med. 2005 Dec 5;202(11):1575-85.
PMID: 16330816 [PubMed - indexed for MEDLINE]
0399. Poonepalli A, Balakrishnan L, Khaw AK, Low GK, Jayapal M, Bhattacharjee RN, Akira S, Balajee AS, Hande MP.
Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite.
Cancer Res. 2005 Dec 1;65(23):10977-83.
PMID: 16322246 [PubMed - indexed for MEDLINE]
0398. Okabe Y, Kawane K, Akira S, Taniguchi T, Nagata S.
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation.
J Exp Med. 2005 Nov 21;202(10):1333-9.
PMID: 16301743 [PubMed - indexed for MEDLINE]
0397. Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS.
Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli.
J Immunol. 2005 Dec 1;175(11):7484-95.
PMID: 16301656 [PubMed - indexed for MEDLINE]
0396. Bhattacharjee RN, Park KS, Uematsu S, Okada K, Hoshino K, Takeda K, Takeuchi O, Akira S, Iida T, Honda T.
Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest.
FEBS Lett. 2005 Dec 5;579(29):6604-10. Epub 2005 Nov 9.
PMID: 16297916 [PubMed - indexed for MEDLINE]
0395. Kimura A, Naka T, Muta T, Takeuchi O, Akira S, Kawase I, Kishimoto T.
Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT.
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17089-94. Epub 2005 Nov 15.
PMID: 16287972 [PubMed - indexed for MEDLINE]
0394. Delale T, Paquin A, Asselin-Paturel C, Dalod M, Brizard G, Bates EE, Kastner P, Chan S, Akira S, Vicari A, Biron CA, Trinchieri G, Briere F.
MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
J Immunol. 2005 Nov 15;175(10):6723-32.
PMID: 16272328 [PubMed - indexed for MEDLINE]
0393. Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S.
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
Genes Dev. 2005 Nov 15;19(22):2668-81. Epub 2005 Oct 31.
PMID: 16260493 [PubMed - indexed for MEDLINE]
0392. Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A.
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.
J Exp Med. 2005 Nov 7;202(9):1171-7. Epub 2005 Oct 31.
PMID: 16260486 [PubMed - indexed for MEDLINE]
0391. Wieland CW, Florquin S, Maris NA, Hoebe K, Beutler B, Takeda K, Akira S, van der Poll T.
The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung.
J Immunol. 2005 Nov 1;175(9):6042-9.
PMID: 16237099 [PubMed - indexed for MEDLINE]
0390. Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL.
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.
J Exp Med. 2005 Oct 17;202(8):1131-9.
PMID: 16230478 [PubMed - indexed for MEDLINE]
0389. Sato N, Kawai T, Sugiyama K, Muromoto R, Imoto S, Sekine Y, Ishida M, Akira S, Matsuda T.
Physical and functional interactions between STAT3 and ZIP kinase.
Int Immunol. 2005 Dec;17(12):1543-52. Epub 2005 Oct 11.
PMID: 16219639 [PubMed - indexed for MEDLINE]
0388. Fuse K, Chan G, Liu Y, Gudgeon P, Husain M, Chen M, Yeh WC, Akira S, Liu PP.
Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of Coxsackievirus B3-induced myocarditis and influences type I interferon production.
Circulation. 2005 Oct 11;112(15):2276-85.
PMID: 16216974 [PubMed - indexed for MEDLINE]
0387. Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks BG, Schoenemeyer A, Yamamoto M, Akira S, Fitzgerald KA.
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
J Immunol. 2005 Oct 15;175(8):5260-8.
PMID: 16210631 [PubMed - indexed for MEDLINE]
0386. Baratin M, Roetynck S, Lepolard C, Falk C, Sawadogo S, Uematsu S, Akira S, Ryffel B, Tiraby JG, Alexopoulou L, Kirschning CJ, Gysin J, Vivier E, Ugolini S.
Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum.
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14747-52. Epub 2005 Oct 3.
PMID: 16203971 [PubMed - indexed for MEDLINE]
0385. Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S.
Essential function for the kinase TAK1 in innate and adaptive immune responses.
Nat Immunol. 2005 Nov;6(11):1087-95. Epub 2005 Sep 25.
PMID: 16186825 [PubMed - indexed for MEDLINE]
0384. Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, Akira S, van der Poll T, Weening JJ, Florquin S.
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.
J Clin Invest. 2005 Oct;115(10):2894-903.
PMID: 16167081 [PubMed - indexed for MEDLINE]
0383. Huang LY, Ishii KJ, Akira S, Aliberti J, Golding B.
Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9.
J Immunol. 2005 Sep 15;175(6):3964-70.
PMID: 16148144 [PubMed - indexed for MEDLINE]
0382. Yukawa K, Tanaka T, Owada-Makabe K, Tsubota Y, Bai T, Maeda M, Takeda K, Akira S, Iso H.
Reduced prepulse inhibition of startle in STAT6-deficient mice.
Int J Mol Med. 2005 Oct;16(4):673-5.
PMID: 16142403 [PubMed - indexed for MEDLINE]
0381. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S.
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Nat Immunol. 2005 Oct;6(10):981-8. Epub 2005 Aug 28.
PMID: 16127453 [PubMed - indexed for MEDLINE]
0380. Matsukawa A, Kudo S, Maeda T, Numata K, Watanabe H, Takeda K, Akira S, Ito T.
Stat3 in resident macrophages as a repressor protein of inflammatory response.
J Immunol. 2005 Sep 1;175(5):3354-9.
PMID: 16116228 [PubMed - indexed for MEDLINE]
0379. Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH.
Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.
J Immunol. 2005 Sep 1;175(5):3339-46.
PMID: 16116226 [PubMed - indexed for MEDLINE]
0378. Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, Foy E, Loo YM, Gale M Jr, Akira S, Yonehara S, Kato A, Fujita T.
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
J Immunol. 2005 Sep 1;175(5):2851-8.
PMID: 16116171 [PubMed - indexed for MEDLINE]
0377. Balloy V, Si-Tahar M, Takeuchi O, Philippe B, Nahori MA, Tanguy M, Huerre M, Akira S, Latge JP, Chignard M.
Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.
Infect Immun. 2005 Sep;73(9):5420-5.
PMID: 16113258 [PubMed - indexed for MEDLINE]
0376. Haga S, Ogawa W, Inoue H, Terui K, Ogino T, Igarashi R, Takeda K, Akira S, Enosawa S, Furukawa H, Todo S, Ozaki M.
Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice.
J Hepatol. 2005 Nov;43(5):799-807. Epub 2005 May 31.
PMID: 16083985 [PubMed - indexed for MEDLINE]
0375. Yukawa K, Hoshino K, Kishino M, Tsubota Y, Owada-Makabe K, Maeda M, Bai T, Tanaka T, Akira S.
Deletion of the kinase domain from death-associated protein kinase attenuates p53 expression in chronic obstructive uropathy.
Int J Mol Med. 2005 Sep;16(3):389-93.
PMID: 16077944 [PubMed - indexed for MEDLINE]
0374. Bhattacharjee RN, Park KS, Okada K, Kumagai Y, Uematsu S, Takeuchi O, Akira S, Iida T, Honda T.
Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus.
Biochem Biophys Res Commun. 2005 Sep 23;335(2):328-34.
PMID: 16061205 [PubMed - indexed for MEDLINE]
0373. Amcheslavsky A, Hemmi H, Akira S, Bar-Shavit Z.
Differential contribution of osteoclast- and osteoblast-lineage cells to CpG-oligodeoxynucleotide (CpG-ODN) modulation of osteoclastogenesis.
J Bone Miner Res. 2005 Sep;20(9):1692-9. Epub 2005 May 23.
PMID: 16059640 [PubMed - indexed for MEDLINE]
0372. Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R.
Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Cell Metab. 2005 Jan;1(1):27-39.
PMID: 16054042 [PubMed - indexed for MEDLINE]
0371. Takeshita F, Ishii KJ, Kobiyama K, Kojima Y, Coban C, Sasaki S, Ishii N, Klinman DM, Okuda K, Akira S, Suzuki K.
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.
Eur J Immunol. 2005 Aug;35(8):2477-85.
PMID: 16052631 [PubMed - indexed for MEDLINE]
0370. Ishii KJ, Ito S, Tamura T, Hemmi H, Conover J, Ozato K, Akira S, Klinman DM.
CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection.
Eur J Immunol. 2005 Aug;35(8):2397-405.
PMID: 16047338 [PubMed - indexed for MEDLINE]
0369. Ohkawara T, Takeda H, Nishihira J, Miyashita K, Nihiwaki M, Ishiguro Y, Takeda K, Akira S, Iwanaga T, Sugiyama T, Asaka M.
Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice.
Clin Exp Immunol. 2005 Sep;141(3):412-21.
PMID: 16045730 [PubMed - indexed for MEDLINE]
0368. Weiss DS, Takeda K, Akira S, Zychlinsky A, Moreno E.
MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus.
Infect Immun. 2005 Aug;73(8):5137-43.
PMID: 16041030 [PubMed - indexed for MEDLINE]
0367. Mun HS, Aosai F, Norose K, Piao LX, Fang H, Akira S, Yano A.
Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70.
Infect Immun. 2005 Aug;73(8):4634-42.
PMID: 16040976 [PubMed - indexed for MEDLINE]
0366. Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S.
Cell type-specific involvement of RIG-I in antiviral response.
Immunity. 2005 Jul;23(1):19-28.
PMID: 16039576 [PubMed - indexed for MEDLINE]
0365. Yang S, Takahashi N, Yamashita T, Sato N, Takahashi M, Mogi M, Uematsu T, Kobayashi Y, Nakamichi Y, Takeda K, Akira S, Takada H, Udagawa N, Furusawa K.
Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts.
J Immunol. 2005 Aug 1;175(3):1956-64.
PMID: 16034140 [PubMed - indexed for MEDLINE]
0364. Christensen SR, Kashgarian M, Alexopoulou L, Flavell RA, Akira S, Shlomchik MJ.
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.
J Exp Med. 2005 Jul 18;202(2):321-31.
PMID: 16027240 [PubMed - indexed for MEDLINE]
0363. Rasschaert J, Ladriere L, Urbain M, Dogusan Z, Katabua B, Sato S, Akira S, Gysemans C, Mathieu C, Eizirik DL.
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+interferon-gamma-induced apoptosis in primary pancreatic beta-cells.
J Biol Chem. 2005 Oct 7;280(40):33984-91. Epub 2005 Jul 15.
PMID: 16027122 [PubMed - indexed for MEDLINE]
0362. de Jonge WJ, van der Zanden EP, The FO, Bijlsma MF, van Westerloo DJ, Bennink RJ, Berthoud HR, Uematsu S, Akira S, van den Wijngaard RM, Boeckxstaens GE.
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.
Nat Immunol. 2005 Aug;6(8):844-51. Epub 2005 Jul 17. Erratum in: Nat Immunol. 2005 Sep;6(9):954.
PMID: 16025117 [PubMed - indexed for MEDLINE]
0361. Shindou H, Ishii S, Yamamoto M, Takeda K, Akira S, Shimizu T.
Priming effect of lipopolysaccharide on acetyl-coenzyme A:lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent.
J Immunol. 2005 Jul 15;175(2):1177-83.
PMID: 16002720 [PubMed - indexed for MEDLINE]
0360. Ikeda-Matsuo Y, Ikegaya Y, Matsuki N, Uematsu S, Akira S, Sasaki Y.
Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.
J Neurochem. 2005 Sep;94(6):1546-58. Epub 2005 Jul 5.
PMID: 16000148 [PubMed - indexed for MEDLINE]
0359. Kato Y, Iwama A, Tadokoro Y, Shimoda K, Minoguchi M, Akira S, Tanaka M, Miyajima A, Kitamura T, Nakauchi H.
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.
J Exp Med. 2005 Jul 4;202(1):169-79.
PMID: 15998795 [PubMed - indexed for MEDLINE]
0358. Boasen J, Chisholm D, Lebet L, Akira S, Horner AA.
House dust extracts elicit Toll-like receptor-dependent dendritic cell responses.
J Allergy Clin Immunol. 2005 Jul;116(1):185-91.
PMID: 15990793 [PubMed - indexed for MEDLINE]
0357. Kanemitsu N, Ebisuno Y, Tanaka T, Otani K, Hayasaka H, Kaisho T, Akira S, Katagiri K, Kinashi T, Fujita N, Tsuruo T, Miyasaka M.
CXCL13 is an arrest chemokine for B cells in high endothelial venules.
Blood. 2005 Oct 15;106(8):2613-8. Epub 2005 Jun 21.
PMID: 15972452 [PubMed - indexed for MEDLINE]
0356. Yang R, Murillo FM, Delannoy MJ, Blosser RL, Yutzy WH 4th, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB.
B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88.
J Immunol. 2005 Jun 15;174(12):7912-9.
PMID: 15944297 [PubMed - indexed for MEDLINE]
0355. Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, Shingai M, Matsumoto M, Azuma I, Toyoshima K, Kusumoto S, Seya T.
Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.
J Immunol. 2005 Jun 1;174(11):7096-103.
PMID: 15905553 [PubMed - indexed for MEDLINE]
0354. Nagai Y, Kobayashi T, Motoi Y, Ishiguro K, Akashi S, Saitoh S, Kusumoto Y, Kaisho T, Akira S, Matsumoto M, Takatsu K, Miyake K.
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
J Immunol. 2005 Jun 1;174(11):7043-9.
PMID: 15905547 [PubMed - indexed for MEDLINE]
0353. Hayashi EA, Akira S, Nobrega A.
Role of TLR in B cell development: signaling through TLR4 promotes B cell maturation and is inhibited by TLR2.
J Immunol. 2005 Jun 1;174(11):6639-47.
PMID: 15905502 [PubMed - indexed for MEDLINE]
0352. Yang R, Wheeler CM, Chen X, Uematsu S, Takeda K, Akira S, Pastrana DV, Viscidi RP, Roden RB.
Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer.
J Virol. 2005 Jun;79(11):6741-50.
PMID: 15890912 [PubMed - indexed for MEDLINE]
0351. Kitching AR, Turner AL, Wilson GR, Semple T, Odobasic D, Timoshanko JR, O'Sullivan KM, Tipping PG, Takeda K, Akira S, Holdsworth SR.
IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment.
J Am Soc Nephrol. 2005 Jul;16(7):2023-33. Epub 2005 May 11.
PMID: 15888563 [PubMed - indexed for MEDLINE]
0350. Henneke P, Morath S, Uematsu S, Weichert S, Pfitzenmaier M, Takeuchi O, Muller A, Poyart C, Akira S, Berner R, Teti G, Geyer A, Hartung T, Trieu-Cuot P, Kasper DL, Golenbock DT.
Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
J Immunol. 2005 May 15;174(10):6449-55.
PMID: 15879147 [PubMed - indexed for MEDLINE]
0349. Mansur DS, Kroon EG, Nogueira ML, Arantes RM, Rodrigues SC, Akira S, Gazzinelli RT, Campos MA.
Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1.
Am J Pathol. 2005 May;166(5):1419-26.
PMID: 15855642 [PubMed - indexed for MEDLINE]
0348. Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya-Tsuji J.
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.
Genes Cells. 2005 May;10(5):447-54.
PMID: 15836773 [PubMed - indexed for MEDLINE]
0347. Karaya K, Mori S, Kimoto H, Shima Y, Tsuji Y, Kurooka H, Akira S, Yokota Y.
Regulation of Id2 expression by CCAAT/enhancer binding protein beta.
Nucleic Acids Res. 2005 Apr 4;33(6):1924-34. Print 2005.
PMID: 15809228 [PubMed - indexed for MEDLINE]
0346. Yukawa K, Iso H, Tanaka T, Tsubota Y, Owada-Makabe K, Bai T, Takeda K, Akira S, Maeda M.
Down-regulation of dopamine transporter and abnormal behavior in STAT6-deficient mice.
Int J Mol Med. 2005 May;15(5):819-25.
PMID: 15806304 [PubMed - indexed for MEDLINE]
0345. Asai Y, Hashimoto M, Fletcher HM, Miyake K, Akira S, Ogawa T.
Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling.
Infect Immun. 2005 Apr;73(4):2157-63.
PMID: 15784558 [PubMed - indexed for MEDLINE]
0344. Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T, Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, Gordon S, Akira S, Nakamura T, Sakaguchi S.
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.
J Exp Med. 2005 Mar 21;201(6):949-60.
PMID: 15781585 [PubMed - indexed for MEDLINE]
0343. Kumanogoh A, Shikina T, Suzuki K, Uematsu S, Yukawa K, Kashiwamura S, Tsutsui H, Yamamoto M, Takamatsu H, Ko-Mitamura EP, Takegahara N, Marukawa S, Ishida I, Morishita H, Prasad DV, Tamura M, Mizui M, Toyofuku T, Akira S, Takeda K, Okabe M, Kikutani H.
Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.
Immunity. 2005 Mar;22(3):305-16.
PMID: 15780988 [PubMed - indexed for MEDLINE]
0342. Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS.
Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium.
Am J Respir Cell Mol Biol. 2005 Jun;32(6):531-9. Epub 2005 Mar 18.
PMID: 15778492 [PubMed - indexed for MEDLINE]
0341. Kalis C, Gumenscheimer M, Freudenberg N, Tchaptchet S, Fejer G, Heit A, Akira S, Galanos C, Freudenberg MA.
Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.
J Immunol. 2005 Apr 1;174(7):4295-300.
PMID: 15778393 [PubMed - indexed for MEDLINE]
0340. Breiman A, Grandvaux N, Lin R, Ottone C, Akira S, Yoneyama M, Fujita T, Hiscott J, Meurs EF.
Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.
J Virol. 2005 Apr;79(7):3969-78.
PMID: 15767399 [PubMed - indexed for MEDLINE]
0339. Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S.
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
J Exp Med. 2005 Mar 21;201(6):915-23. Epub 2005 Mar 14.
PMID: 15767370 [PubMed - indexed for MEDLINE]
0338. Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS.
PI3K integrates the action of insulin and leptin on hypothalamic neurons.
J Clin Invest. 2005 Apr;115(4):951-8. Epub 2005 Mar 10.
PMID: 15761497 [PubMed - indexed for MEDLINE]
0337. Hirotani T, Lee PY, Kuwata H, Yamamoto M, Matsumoto M, Kawase I, Akira S, Takeda K.
The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria.
J Immunol. 2005 Mar 15;174(6):3650-7.
PMID: 15749903 [PubMed - indexed for MEDLINE]
0336. Seki E, Tsutsui H, Iimuro Y, Naka T, Son G, Akira S, Kishimoto T, Nakanishi K, Fujimoto J.
Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration.
Hepatology. 2005 Mar;41(3):443-50.
PMID: 15723296 [PubMed - indexed for MEDLINE]
0335. Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G.
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.
Nat Med. 2005 Mar;11(3):263-70. Epub 2005 Feb 20.
PMID: 15723075 [PubMed - indexed for MEDLINE]
0334. Abe T, Hemmi H, Miyamoto H, Moriishi K, Tamura S, Takaku H, Akira S, Matsuura Y.
Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus.
J Virol. 2005 Mar;79(5):2847-58.
PMID: 15709004 [PubMed - indexed for MEDLINE]
0333. Sugiyama T, Gursel M, Takeshita F, Coban C, Conover J, Kaisho T, Akira S, Klinman DM, Ishii KJ.
CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes.
J Immunol. 2005 Feb 15;174(4):2273-9. Erratum in: J Immunol. 2005 Aug 1;175(3):2026.
PMID: 15699162 [PubMed - indexed for MEDLINE]
0332. Suzuki T, Nakanishi K, Tsutsui H, Iwai H, Akira S, Inohara N, Chamaillard M, Nunez G, Sasakawa C.
A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages.
J Biol Chem. 2005 Apr 8;280(14):14042-50. Epub 2005 Feb 4.
PMID: 15695506 [PubMed - indexed for MEDLINE]
0331. Hirotani T, Yamamoto M, Kumagai Y, Uematsu S, Kawase I, Takeuchi O, Akira S.
Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.
Biochem Biophys Res Commun. 2005 Mar 11;328(2):383-92.
PMID: 15694359 [PubMed - indexed for MEDLINE]
0330. Araki A, Kanai T, Ishikura T, Makita S, Uraushihara K, Iiyama R, Totsuka T, Takeda K, Akira S, Watanabe M.
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.
J Gastroenterol. 2005 Jan;40(1):16-23.
PMID: 15692785 [PubMed - indexed for MEDLINE]
0329. Ueta M, Hamuro J, Yamamoto M, Kaseda K, Akira S, Kinoshita S.
Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice.
Invest Ophthalmol Vis Sci. 2005 Feb;46(2):579-88.
PMID: 15671285 [PubMed - indexed for MEDLINE]
0328. Kamezaki K, Shimoda K, Numata A, Haro T, Kakumitsu H, Yoshie M, Yamamoto M, Takeda K, Matsuda T, Akira S, Ogawa K, Harada M.
Roles of Stat3 and ERK in G-CSF signaling.
Stem Cells. 2005 Feb;23(2):252-63.
PMID: 15671148 [PubMed - indexed for MEDLINE]
0327. Hapfelmeier S, Stecher B, Barthel M, Kremer M, Muller AJ, Heikenwalder M, Stallmach T, Hensel M, Pfeffer K, Akira S, Hardt WD.
The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.
J Immunol. 2005 Feb 1;174(3):1675-85.
PMID: 15661931 [PubMed - indexed for MEDLINE]
0326. Saitoh T, Yamamoto M, Miyagishi M, Taira K, Nakanishi M, Fujita T, Akira S, Yamamoto N, Yamaoka S.
A20 is a negative regulator of IFN regulatory factor 3 signaling.
J Immunol. 2005 Feb 1;174(3):1507-12.
PMID: 15661910 [PubMed - indexed for MEDLINE]
0325. Sawamura D, Abe R, Goto M, Akiyama M, Hemmi H, Akira S, Shimizu H.
Direct injection of plasmid DNA into the skin induces dermatitis by activation of monocytes through toll-like receptor 9.
J Gene Med. 2005 May;7(5):664-71.
PMID: 15655803 [PubMed - indexed for MEDLINE]
0324. Lang KS, Recher M, Junt T, Navarini AA, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther SA, Uematsu S, Akira S, Hengartner H, Zinkernagel RM.
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.
Nat Med. 2005 Feb;11(2):138-45. Epub 2005 Jan 16. Erratum in: Nat Med. 2005 Nov;11(11):1256.
PMID: 15654326 [PubMed - indexed for MEDLINE]
0323. Saemann MD, Weichhart T, Zeyda M, Staffler G, Schunn M, Stuhlmeier KM, Sobanov Y, Stulnig TM, Akira S, von Gabain A, von Ahsen U, Horl WH, Zlabinger GJ.
Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism.
J Clin Invest. 2005 Feb;115(2):468-75.
PMID: 15650774 [PubMed - indexed for MEDLINE]
0322. Yukawa K, Kishino M, Goda M, Liang XM, Kimura A, Tanaka T, Bai T, Owada-Makabe K, Tsubota Y, Ueyama T, Ichinose M, Maeda M, Takeda K, Akira S.
STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy.
Int J Mol Med. 2005 Feb;15(2):225-30.
PMID: 15647835 [PubMed - indexed for MEDLINE]
0321. Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S.
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
J Exp Med. 2005 Jan 3;201(1):19-25.
PMID: 15630134 [PubMed - indexed for MEDLINE]
0320. Krishnegowda G, Hajjar AM, Zhu J, Douglass EJ, Uematsu S, Akira S, Woods AS, Gowda DC.
Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity.
J Biol Chem. 2005 Mar 4;280(9):8606-16. Epub 2004 Dec 28.
PMID: 15623512 [PubMed - indexed for MEDLINE]
0319. Akamine M, Higa F, Arakaki N, Kawakami K, Takeda K, Akira S, Saito A.
Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila.
Infect Immun. 2005 Jan;73(1):352-61.
PMID: 15618172 [PubMed - indexed for MEDLINE]
0318. Van Der Sluijs KF, Van Elden LJ, Arens R, Nijhuis M, Schuurman R, Florquin S, Kwakkel J, Akira S, Jansen HM, Lutter R, Van Der Polls T.
Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus.
Immunology. 2005 Jan;114(1):112-20.
PMID: 15606801 [PubMed - indexed for MEDLINE]
0317. Yukawa K, Kishino M, Hoshino K, Shirasawa N, Kimura A, Tsubota Y, Owada-Makabe K, Bai T, Tanaka T, Ueyama T, Ichinose M, Takeda K, Akira S, Maeda M.
The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy.
Int J Mol Med. 2005 Jan;15(1):73-8.
PMID: 15583830 [PubMed - indexed for MEDLINE]
0316. Buwitt-Beckmann U, Heine H, Wiesmuller KH, Jung G, Brock R, Akira S, Ulmer AJ.
Toll-like receptor 6-independent signaling by diacylated lipopeptides.
Eur J Immunol. 2005 Jan;35(1):282-9.
PMID: 15580661 [PubMed - indexed for MEDLINE]
0315. Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M, Si-Tahar M.
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.
J Biol Chem. 2005 Feb 18;280(7):5571-80. Epub 2004 Dec 3.
PMID: 15579900 [PubMed - indexed for MEDLINE]