0314. Stockinger S, Reutterer B, Schaljo B, Schellack C, Brunner S, Materna T, Yamamoto M, Akira S, Taniguchi T, Murray PJ, Muller M, Decker T.
IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.
J Immunol. 2004 Dec 15;173(12):7416-25.
PMID: 15585867 [PubMed - indexed for MEDLINE]
0313. Suzuki Y, Wakita D, Chamoto K, Narita Y, Tsuji T, Takeshima T, Gyobu H, Kawarada Y, Kondo S, Akira S, Katoh H, Ikeda H, Nishimura T.
Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity.
Cancer Res. 2004 Dec 1;64(23):8754-60.
PMID: 15574787 [PubMed - indexed for MEDLINE]
0312. Knuefermann P, Sakata Y, Baker JS, Huang CH, Sekiguchi K, Hardarson HS, Takeuchi O, Akira S, Vallejo JG.
Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart.
Circulation. 2004 Dec 14;110(24):3693-8. Epub 2004 Nov 29.
PMID: 15569836 [PubMed - indexed for MEDLINE]
0311. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A.
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.
Nature. 2004 Dec 16;432(7019):917-21. Epub 2004 Nov 7.
PMID: 15531878 [PubMed - indexed for MEDLINE]
0310. Hosoi T, Wada S, Suzuki S, Okuma Y, Akira S, Matsuda T, Nomura Y.
Bacterial endotoxin induces IL-20 expression in the glial cells.
Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):23-9.
PMID: 15519673 [PubMed - indexed for MEDLINE]
0309. Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, Noda T, Taniguchi S.
ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.
Genes Cells. 2004 Nov;9(11):1055-67.
PMID: 15507117 [PubMed - indexed for MEDLINE]
0308. Oliveira AC, Peixoto JR, de Arruda LB, Campos MA, Gazzinelli RT, Golenbock DT, Akira S, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M.
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
J Immunol. 2004 Nov 1;173(9):5688-96.
PMID: 15494520 [PubMed - indexed for MEDLINE]
0307. Hikoso S, Yamaguchi O, Higuchi Y, Hirotani S, Takeda T, Kashiwase K, Watanabe T, Taniike M, Tsujimoto I, Asahi M, Matsumura Y, Nishida K, Nakajima H, Akira S, Hori M, Otsu K.
Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice.
Circulation. 2004 Oct 26;110(17):2631-7. Epub 2004 Oct 18.
PMID: 15492321 [PubMed - indexed for MEDLINE]
0306. Chaisson ML, Branstetter DG, Derry JM, Armstrong AP, Tometsko ME, Takeda K, Akira S, Dougall WC.
Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha.
J Biol Chem. 2004 Dec 24;279(52):54841-8. Epub 2004 Oct 14.
PMID: 15485831 [PubMed - indexed for MEDLINE]
0305. Kirino Y, Yasukawa T, Ohta S, Akira S, Ishihara K, Watanabe K, Suzuki T.
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease.
Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15070-5. Epub 2004 Oct 11.
PMID: 15477592 [PubMed - indexed for MEDLINE]
0304. Yang R, Murillo FM, Cui H, Blosser R, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB.
Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88.
J Virol. 2004 Oct;78(20):11152-60.
PMID: 15452235 [PubMed - indexed for MEDLINE]
0303. Wieland CW, Knapp S, Florquin S, de Vos AF, Takeda K, Akira S, Golenbock DT, Verbon A, van der Poll T.
Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
Am J Respir Crit Care Med. 2004 Dec 15;170(12):1367-74. Epub 2004 Sep 24.
PMID: 15447943 [PubMed - indexed for MEDLINE]
0302. Nakasone C, Kawakami K, Hoshino T, Kawase Y, Yokota K, Yoshino K, Takeda K, Akira S, Saito A.
Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice.
Infect Immun. 2004 Oct;72(10):6176-80.
PMID: 15385528 [PubMed - indexed for MEDLINE]
0301. Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, Krieg AM, Lipford GB, Viglianti GA, Rifkin IR.
Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells.
J Endotoxin Res. 2004;10(4):247-51.
PMID: 15373969 [PubMed - indexed for MEDLINE]
0300. Vossenkamper A, Struck D, Alvarado-Esquivel C, Went T, Takeda K, Akira S, Pfeffer K, Alber G, Lochner M, Forster I, Liesenfeld O.
Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control.
Eur J Immunol. 2004 Nov;34(11):3197-207.
PMID: 15368276 [PubMed - indexed for MEDLINE]
0299. tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC, Lin R, Hiscott J.
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
J Virol. 2004 Oct;78(19):10636-49.
PMID: 15367631 [PubMed - indexed for MEDLINE]
0298. Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue J, Uematsu S, Takeuchi O, Akira S.
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
Nat Immunol. 2004 Oct;5(10):1061-8. Epub 2004 Sep 7.
PMID: 15361868 [PubMed - indexed for MEDLINE]
0297. Sato N, Takahashi N, Suda K, Nakamura M, Yamaki M, Ninomiya T, Kobayashi Y, Takada H, Shibata K, Yamamoto M, Takeda K, Akira S, Noguchi T, Udagawa N.
MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha.
J Exp Med. 2004 Sep 6;200(5):601-11.
PMID: 15353553 [PubMed - indexed for MEDLINE]
0296. Krug A, French AR, Barchet W, Fischer JA, Dzionek A, Pingel JT, Orihuela MM, Akira S, Yokoyama WM, Colonna M.
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.
Immunity. 2004 Jul;21(1):107-19.
PMID: 15345224 [PubMed - indexed for MEDLINE]
0295. Takeji M, Kawada N, Moriyama T, Nagatoya K, Oseto S, Akira S, Hori M, Imai E, Miwa T.
CCAAT/Enhancer-binding protein delta contributes to myofibroblast transdifferentiation and renal disease progression.
J Am Soc Nephrol. 2004 Sep;15(9):2383-90.
PMID: 15339987 [PubMed - indexed for MEDLINE]
0294. Kudo M, Aosai F, Mun HS, Norose K, Akira S, Iwakura Y, Yano A.
The role of IFN-gamma and Toll-like receptors in nephropathy induced by Toxoplasma gondii infection.
Microbiol Immunol. 2004;48(8):617-28.
PMID: 15322342 [PubMed - indexed for MEDLINE]
0293. Jang S, Uematsu S, Akira S, Salgame P.
IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition.
J Immunol. 2004 Sep 1;173(5):3392-7.
PMID: 15322203 [PubMed - indexed for MEDLINE]
0292. Sumi K, Yokozeki H, Wu MH, Satoh T, Kaneda Y, Takeda K, Akira S, Nishioka K.
In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity.
Gene Ther. 2004 Dec;11(24):1763-71.
PMID: 15306843 [PubMed - indexed for MEDLINE]
0291. Yokozeki H, Wu MH, Sumi K, Awad S, Satoh T, Katayama I, Takeda K, Akira S, Kaneda Y, Nishioka K.
In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model.
Gene Ther. 2004 Dec;11(24):1753-62.
PMID: 15306842 [PubMed - indexed for MEDLINE]
0290. Smith RM, Suleman N, Lacerda L, Opie LH, Akira S, Chien KR, Sack MN.
Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning.
Cardiovasc Res. 2004 Sep 1;63(4):611-6.
PMID: 15306216 [PubMed - indexed for MEDLINE]
0289. Yang R, Murillo FM, Lin KY, Yutzy WH 4th, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB.
Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations.
J Immunol. 2004 Aug 15;173(4):2624-31.
PMID: 15294979 [PubMed - indexed for MEDLINE]
0288. Okamoto M, Furuichi S, Nishioka Y, Oshikawa T, Tano T, Ahmed SU, Takeda K, Akira S, Ryoma Y, Moriya Y, Saito M, Sone S, Sato M.
Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation.
Cancer Res. 2004 Aug 1;64(15):5461-70.
PMID: 15289356 [PubMed - indexed for MEDLINE]
0287. Bolz DD, Sundsbak RS, Ma Y, Akira S, Kirschning CJ, Zachary JF, Weis JH, Weis JJ.
MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.
J Immunol. 2004 Aug 1;173(3):2003-10.
PMID: 15265935 [PubMed - indexed for MEDLINE]
0286. Nicolle DM, Pichon X, Bouchot A, Maillet I, Erard F, Akira S, Ryffel B, Quesniaux VF.
Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice.
Lab Invest. 2004 Oct;84(10):1305-21.
PMID: 15258598 [PubMed - indexed for MEDLINE]
0285. Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M.
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10679-84. Epub 2004 Jul 12.
PMID: 15249654 [PubMed - indexed for MEDLINE]
0284. Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S.
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.
Nature. 2004 Jul 8;430(6996):218-22.
PMID: 15241416 [PubMed - indexed for MEDLINE]
0283. Kishino M, Yukawa K, Hoshino K, Kimura A, Shirasawa N, Otani H, Tanaka T, Owada-Makabe K, Tsubota Y, Maeda M, Ichinose M, Takeda K, Akira S, Mune M.
Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.
J Am Soc Nephrol. 2004 Jul;15(7):1826-34.
PMID: 15213270 [PubMed - indexed for MEDLINE]
0282. Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S.
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
J Exp Med. 2004 Jun 21;199(12):1641-50.
PMID: 15210742 [PubMed - indexed for MEDLINE]
0281. Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T.
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Nat Immunol. 2004 Jul;5(7):730-7. Epub 2004 Jun 20.
PMID: 15208624 [PubMed - indexed for MEDLINE]
0280. Ozawa Y, Nakao K, Shimazaki T, Takeda J, Akira S, Ishihara K, Hirano T, Oguchi Y, Okano H.
Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.
Mol Cell Neurosci. 2004 Jun;26(2):258-70.
PMID: 15207851 [PubMed - indexed for MEDLINE]
0279. Boule MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR.
Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.
J Exp Med. 2004 Jun 21;199(12):1631-40. Epub 2004 Jun 14.
PMID: 15197227 [PubMed - indexed for MEDLINE]
0278. Mabuchi T, Kojima H, Abe T, Takagi K, Sakurai M, Ohmiya Y, Uematsu S, Akira S, Watanabe K, Ito S.
Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain.
Neuroreport. 2004 Jun 28;15(9):1395-8.
PMID: 15194860 [PubMed - indexed for MEDLINE]
0277. Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M.
Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.
Biochem Biophys Res Commun. 2004 Jul 9;319(4):1159-70.
PMID: 15194489 [PubMed - indexed for MEDLINE]
0276. Nilsen N, Nonstad U, Khan N, Knetter CF, Akira S, Sundan A, Espevik T, Lien E.
Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88.
J Biol Chem. 2004 Sep 17;279(38):39727-35. Epub 2004 Jun 9.
PMID: 15190057 [PubMed - indexed for MEDLINE]
0275. Dewi BE, Akira S, Hayashi H, Ba-Thein W.
High occurrence of simultaneous mutations in target enzymes and MtrRCDE efflux system in quinolone-resistant Neisseria gonorrhoeae.
Sex Transm Dis. 2004 Jun;31(6):353-9.
PMID: 15167645 [PubMed - indexed for MEDLINE]
0274. Didierlaurent A, Ferrero I, Otten LA, Dubois B, Reinhardt M, Carlsen H, Blomhoff R, Akira S, Kraehenbuhl JP, Sirard JC.
Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response.
J Immunol. 2004 Jun 1;172(11):6922-30.
PMID: 15153511 [PubMed - indexed for MEDLINE]
0273. Kamei D, Yamakawa K, Takegoshi Y, Mikami-Nakanishi M, Nakatani Y, Oh-Ishi S, Yasui H, Azuma Y, Hirasawa N, Ohuchi K, Kawaguchi H, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Kudo I.
Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.
J Biol Chem. 2004 Aug 6;279(32):33684-95. Epub 2004 May 12.
PMID: 15140897 [PubMed - indexed for MEDLINE]
0272. Okamoto M, Oh-E G, Oshikawa T, Furuichi S, Tano T, Ahmed SU, Akashi S, Miyake K, Takeuchi O, Akira S, Himeno K, Sato M, Ohkubo S.
Toll-like receptor 4 mediates the antitumor host response induced by a 55-kilodalton protein isolated from Aeginetia indica L., a parasitic plant.
Clin Diagn Lab Immunol. 2004 May;11(3):483-95.
PMID: 15138173 [PubMed - indexed for MEDLINE]
0271. Hosoi T, Suzuki S, Nomura J, Ono A, Okuma Y, Akira S, Nomura Y.
Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells.
Brain Res Mol Brain Res. 2004 May 19;124(2):159-64.
PMID: 15135224 [PubMed - indexed for MEDLINE]
0270. Mancuso G, Midiri A, Beninati C, Biondo C, Galbo R, Akira S, Henneke P, Golenbock D, Teti G.
Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.
J Immunol. 2004 May 15;172(10):6324-9.
PMID: 15128822 [PubMed - indexed for MEDLINE]
0269. Sakai A, Han J, Cato AC, Akira S, Li JD.
Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells.
BMC Mol Biol. 2004 May 4;5:2.
PMID: 15125785 [PubMed - indexed for MEDLINE]
0268. Qiao H, Sonoda KH, Sassa Y, Hisatomi T, Yoshikawa H, Ikeda Y, Murata T, Akira S, Ishibashi T.
Abnormal retinal vascular development in IL-18 knockout mice.
Lab Invest. 2004 Aug;84(8):973-80.
PMID: 15122309 [PubMed - indexed for MEDLINE]
0267. Takeshita K, Yamasaki T, Akira S, Gantner F, Bacon KB.
Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.
Int Immunol. 2004 May;16(5):685-95. Epub 2004 Mar 29.
PMID: 15096484 [PubMed - indexed for MEDLINE]
0266. Pichyangkul S, Yongvanitchit K, Kum-arb U, Hemmi H, Akira S, Krieg AM, Heppner DG, Stewart VA, Hasegawa H, Looareesuwan S, Shanks GD, Miller RS.
Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway.
J Immunol. 2004 Apr 15;172(8):4926-33.
PMID: 15067072 [PubMed - indexed for MEDLINE]
0265. Dillon S, Agrawal A, Van Dyke T, Landreth G, McCauley L, Koh A, Maliszewski C, Akira S, Pulendran B.
A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells.
J Immunol. 2004 Apr 15;172(8):4733-43.
PMID: 15067049 [PubMed - indexed for MEDLINE]
0264. Kawakami K, Kinjo Y, Uezu K, Miyagi K, Kinjo T, Yara S, Koguchi Y, Miyazato A, Shibuya K, Iwakura Y, Takeda K, Akira S, Saito A.
Interferon-gamma production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18.
Microbes Infect. 2004 Apr;6(4):339-49.
PMID: 15050961 [PubMed - indexed for MEDLINE]
0263. Ikushima H, Nishida T, Takeda K, Ito T, Yasuda T, Yano M, Akira S, Matsuda H.
Expression of Toll-like receptors 2 and 4 is downregulated after operation.
Surgery. 2004 Apr;135(4):376-85.
PMID: 15041961 [PubMed - indexed for MEDLINE]
0262. Torres D, Barrier M, Bihl F, Quesniaux VJ, Maillet I, Akira S, Ryffel B, Erard F.
Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection.
Infect Immun. 2004 Apr;72(4):2131-9.
PMID: 15039335 [PubMed - indexed for MEDLINE]
0261. Weiss DS, Raupach B, Takeda K, Akira S, Zychlinsky A.
Toll-like receptors are temporally involved in host defense.
J Immunol. 2004 Apr 1;172(7):4463-9.
PMID: 15034062 [PubMed - indexed for MEDLINE]
0260. Gomes MS, Florido M, Cordeiro JV, Teixeira CM, Takeuchi O, Akira S, Appelberg R.
Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium.
Immunology. 2004 Feb;111(2):179-85.
PMID: 15027903 [PubMed - indexed for MEDLINE]
0259. Yukawa K, Hoshino K, Kishino M, Mune M, Shirasawa N, Kimura A, Tsubota Y, Owada-Makabe K, Tanaka T, Ichinose M, Maeda M, Takeda K, Akira S.
Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.
Int J Mol Med. 2004 Apr;13(4):515-20.
PMID: 15010850 [PubMed - indexed for MEDLINE]
0258. Honstettre A, Ghigo E, Moynault A, Capo C, Toman R, Akira S, Takeuchi O, Lepidi H, Raoult D, Mege JL.
Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4.
J Immunol. 2004 Mar 15;172(6):3695-703.
PMID: 15004173 [PubMed - indexed for MEDLINE]
0257. Robben PM, Mordue DG, Truscott SM, Takeda K, Akira S, Sibley LD.
Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype.
J Immunol. 2004 Mar 15;172(6):3686-94.
PMID: 15004172 [PubMed - indexed for MEDLINE]
0256. Li Y, Ishii K, Hisaeda H, Hamano S, Zhang M, Nakanishi K, Yoshimoto T, Hemmi H, Takeda K, Akira S, Iwakura Y, Himeno K.
IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: is the effect mediated by the CpG signaling TLR9?
Gene Ther. 2004 Jun;11(11):941-8.
PMID: 14985787 [PubMed - indexed for MEDLINE]
0255. Knapp S, Wieland CW, van 't Veer C, Takeuchi O, Akira S, Florquin S, van der Poll T.
Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense.
J Immunol. 2004 Mar 1;172(5):3132-8.
PMID: 14978119 [PubMed - indexed for MEDLINE]
0254. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S.
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
Science. 2004 Mar 5;303(5663):1526-9. Epub 2004 Feb 19.
PMID: 14976262 [PubMed - indexed for MEDLINE]
0253. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C.
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
Science. 2004 Mar 5;303(5663):1529-31. Epub 2004 Feb 19.
PMID: 14976261 [PubMed - indexed for MEDLINE]
0252. Shiratsuchi A, Watanabe I, Takeuchi O, Akira S, Nakanishi Y.
Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages.
J Immunol. 2004 Feb 15;172(4):2039-47.
PMID: 14764668 [PubMed - indexed for MEDLINE]
0251. Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, Takeda K, Lee J, Takabayashi K, Raz E.
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.
Gastroenterology. 2004 Feb;126(2):520-8.
PMID: 14762789 [PubMed - indexed for MEDLINE]
0250. Zhao H, Hemmi H, Akira S, Cheng SH, Scheule RK, Yew NS.
Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors.
Mol Ther. 2004 Feb;9(2):241-8.
PMID: 14759808 [PubMed - indexed for MEDLINE]
0249. Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A.
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration.
Nat Med. 2004 Feb;10(2):187-92. Epub 2004 Jan 25.
PMID: 14745443 [PubMed - indexed for MEDLINE]
0248. Akazawa T, Masuda H, Saeki Y, Matsumoto M, Takeda K, Tsujimura K, Kuzushima K, Takahashi T, Azuma I, Akira S, Toyoshima K, Seya T.
Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice.
Cancer Res. 2004 Jan 15;64(2):757-64.
PMID: 14744795 [PubMed - indexed for MEDLINE]
0247. Campos MA, Closel M, Valente EP, Cardoso JE, Akira S, Alvarez-Leite JI, Ropert C, Gazzinelli RT.
Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.
J Immunol. 2004 Feb 1;172(3):1711-8.
PMID: 14734753 [PubMed - indexed for MEDLINE]
0246. Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M.
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.
Nat Med. 2004 Feb;10(2):168-74. Epub 2004 Jan 11.
PMID: 14716305 [PubMed - indexed for MEDLINE]
0245. Sasaki H, Balto K, Kawashima N, Eastcott J, Hoshino K, Akira S, Stashenko P.
Gamma interferon (IFN-gamma) and IFN-gamma-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resorption in vivo.
Clin Diagn Lab Immunol. 2004 Jan;11(1):106-10.
PMID: 14715554 [PubMed - indexed for MEDLINE]
0244. Into T, Kiura K, Yasuda M, Kataoka H, Inoue N, Hasebe A, Takeda K, Akira S, Shibata K.
Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation.
Cell Microbiol. 2004 Feb;6(2):187-99.
PMID: 14706104 [PubMed - indexed for MEDLINE]
0243. Hokuto I, Ikegami M, Yoshida M, Takeda K, Akira S, Perl AK, Hull WM, Wert SE, Whitsett JA.
Stat-3 is required for pulmonary homeostasis during hyperoxia.
J Clin Invest. 2004 Jan;113(1):28-37.
PMID: 14702106 [PubMed - indexed for MEDLINE]
0242. Wan J, Sun L, Mendoza JW, Chui YL, Huang DP, Chen ZJ, Suzuki N, Suzuki S, Yeh WC, Akira S, Matsumoto K, Liu ZG, Wu Z.
Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1.
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