0240. Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E.
Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15595-600. Epub 2003 Dec 12.
PMID: 14673102 [PubMed - indexed for MEDLINE]
0239. Serbina NV, Kuziel W, Flavell R, Akira S, Rollins B, Pamer EG.
Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection.
Immunity. 2003 Dec;19(6):891-901.
PMID: 14670305 [PubMed - indexed for MEDLINE]
0238. Shishido T, Nozaki N, Yamaguchi S, Shibata Y, Nitobe J, Miyamoto T, Takahashi H, Arimoto T, Maeda K, Yamakawa M, Takeuchi O, Akira S, Takeishi Y, Kubota I.
Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction.
Circulation. 2003 Dec 9;108(23):2905-10. Epub 2003 Dec 1.
PMID: 14656915 [PubMed - indexed for MEDLINE]
0237. Sugawara I, Yamada H, Mizuno S, Takeda K, Akira S.
Mycobacterial infection in MyD88-deficient mice.
Microbiol Immunol. 2003;47(11):841-7.
PMID: 14638995 [PubMed - indexed for MEDLINE]
0236. Iiyama R, Kanai T, Uraushihara K, Ishikura T, Makita S, Totsuka T, Yamazaki M, Nakamura T, Miyata T, Yoshida H, Takeuchi O, Hoshino K, Takeda K, Ishikawa H, Akira S, Watanabe M.
Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice.
Scand J Immunol. 2003 Dec;58(6):620-7.
PMID: 14636418 [PubMed - indexed for MEDLINE]
0235. Matsukawa A, Takeda K, Kudo S, Maeda T, Kagayama M, Akira S.
Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils.
J Immunol. 2003 Dec 1;171(11):6198-205.
PMID: 14634136 [PubMed - indexed for MEDLINE]
0234. Joosten LA, Koenders MI, Smeets RL, Heuvelmans-Jacobs M, Helsen MM, Takeda K, Akira S, Lubberts E, van de Loo FA, van den Berg WB.
Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88.
J Immunol. 2003 Dec 1;171(11):6145-53.
PMID: 14634130 [PubMed - indexed for MEDLINE]
0233. Suzuki N, Suzuki S, Eriksson U, Hara H, Mirtosis C, Chen NJ, Wada T, Bouchard D, Hwang I, Takeda K, Fujita T, Der S, Penninger JM, Akira S, Saito T, Yeh WC.
IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC.
J Immunol. 2003 Dec 1;171(11):6065-71.
PMID: 14634120 [PubMed - indexed for MEDLINE]
0232. Schirmbeck R, Riedl P, Zurbriggen R, Akira S, Reimann J.
Antigenic epitopes fused to cationic peptide bound to oligonucleotides facilitate Toll-like receptor 9-dependent, but CD4+ T cell help-independent, priming of CD8+T cells.
J Immunol. 2003 Nov 15;171(10):5198-207.
PMID: 14607920 [PubMed - indexed for MEDLINE]
0231. Heil F, Ahmad-Nejad P, Hemmi H, Hochrein H, Ampenberger F, Gellert T, Dietrich H, Lipford G, Takeda K, Akira S, Wagner H, Bauer S.
The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.
Eur J Immunol. 2003 Nov;33(11):2987-97.
PMID: 14579267 [PubMed - indexed for MEDLINE]
0230. Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
Nat Immunol. 2003 Nov;4(11):1144-50. Epub 2003 Oct 12.
PMID: 14556004 [PubMed - indexed for MEDLINE]
0229. Takahasi K, Suzuki NN, Horiuchi M, Mori M, Suhara W, Okabe Y, Fukuhara Y, Terasawa H, Akira S, Fujita T, Inagaki F.
X-ray crystal structure of IRF-3 and its functional implications.
Nat Struct Biol. 2003 Nov;10(11):922-7. Epub 2003 Oct 12.
PMID: 14555995 [PubMed - indexed for MEDLINE]
0228. Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S.
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.
J Immunol. 2003 Oct 15;171(8):4304-10.
PMID: 14530355 [PubMed - indexed for MEDLINE]
0227. Haga S, Terui K, Zhang HQ, Enosawa S, Ogawa W, Inoue H, Okuyama T, Takeda K, Akira S, Ogino T, Irani K, Ozaki M.
Stat3 protects against Fas-induced liver injury by redox-dependent and-independent mechanisms.
J Clin Invest. 2003 Oct;112(7):989-98.
PMID: 14523036 [PubMed - indexed for MEDLINE]
0226. Shi S, Nathan C, Schnappinger D, Drenkow J, Fuortes M, Block E, Ding A, Gingeras TR, Schoolnik G, Akira S, Takeda K, Ehrt S.
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.
J Exp Med. 2003 Oct 6;198(7):987-97. Epub 2003 Sep 29.
PMID: 14517275 [PubMed - indexed for MEDLINE]
0225. Weijer S, Sewnath ME, de Vos AF, Florquin S, van der Sluis K, Gouma DJ, Takeda K, Akira S, van der Poll T.
Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis.
Infect Immun. 2003 Oct;71(10):5488-97.
PMID: 14500466 [PubMed - indexed for MEDLINE]
0224. Cheng F, Wang HW, Cuenca A, Huang M, Ghansah T, Brayer J, Kerr WG, Takeda K, Akira S, Schoenberger SP, Yu H, Jove R, Sotomayor EM.
A critical role for Stat3 signaling in immune tolerance.
Immunity. 2003 Sep;19(3):425-36.
PMID: 14499117 [PubMed - indexed for MEDLINE]
0223. Kariyone A, Tamura T, Kano H, Iwakura Y, Takeda K, Akira S, Takatsu K.
Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gamma.
Int Immunol. 2003 Oct;15(10):1183-94.
PMID: 13679388 [PubMed - indexed for MEDLINE]
0222. Honda K, Sakaguchi S, Nakajima C, Watanabe A, Yanai H, Matsumoto M, Ohteki T, Kaisho T, Takaoka A, Akira S, Seya T, Taniguchi T.
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10872-7. Epub 2003 Sep 5.
PMID: 12960379 [PubMed - indexed for MEDLINE]
0221. Shibue T, Takeda K, Oda E, Tanaka H, Murasawa H, Takaoka A, Morishita Y, Akira S, Taniguchi T, Tanaka N.
Integral role of Noxa in p53-mediated apoptotic response.
Genes Dev. 2003 Sep 15;17(18):2233-8. Epub 2003 Sep 2.
PMID: 12952892 [PubMed - indexed for MEDLINE]
0220. Takagi H, Kanai T, Okazawa A, Kishi Y, Sato T, Takaishi H, Inoue N, Ogata H, Iwao Y, Hoshino K, Takeda K, Akira S, Watanabe M, Ishii H, Hibi T.
Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice.
Scand J Gastroenterol. 2003 Aug;38(8):837-44.
PMID: 12940437 [PubMed - indexed for MEDLINE]
0219. Marr KA, Balajee SA, Hawn TR, Ozinsky A, Pham U, Akira S, Aderem A, Liles WC.
Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens.
Infect Immun. 2003 Sep;71(9):5280-6.
PMID: 12933875 [PubMed - indexed for MEDLINE]
0218. Kawai T, Akira S, Reed JC.
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
Mol Cell Biol. 2003 Sep;23(17):6174-86.
PMID: 12917339 [PubMed - indexed for MEDLINE]
0217. Mun HS, Aosai F, Norose K, Chen M, Piao LX, Takeuchi O, Akira S, Ishikura H, Yano A.
TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection.
Int Immunol. 2003 Sep;15(9):1081-7.
PMID: 12917260 [PubMed - indexed for MEDLINE]
0216. Kuwata H, Watanabe Y, Miyoshi H, Yamamoto M, Kaisho T, Takeda K, Akira S.
IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages.
Blood. 2003 Dec 1;102(12):4123-9. Epub 2003 Aug 7.
PMID: 12907458 [PubMed - indexed for MEDLINE]
0215. Ebisuno Y, Tanaka T, Kanemitsu N, Kanda H, Yamaguchi K, Kaisho T, Akira S, Miyasaka M.
Cutting edge: the B cell chemokine CXC chemokine ligand 13/B lymphocyte chemoattractant is expressed in the high endothelial venules of lymph nodes and Peyer's patches and affects B cell trafficking across high endothelial venules.
J Immunol. 2003 Aug 15;171(4):1642-6.
PMID: 12902460 [PubMed - indexed for MEDLINE]
0214. Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A.
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells.
J Exp Med. 2003 Aug 4;198(3):513-20.
PMID: 12900525 [PubMed - indexed for MEDLINE]
0213. Uehori J, Matsumoto M, Tsuji S, Akazawa T, Takeuchi O, Akira S, Kawata T, Azuma I, Toyoshima K, Seya T.
Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guerin peptidoglycan.
Infect Immun. 2003 Aug;71(8):4238-49.
PMID: 12874299 [PubMed - indexed for MEDLINE]
0212. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Science. 2003 Aug 1;301(5633):640-3. Epub 2003 Jul 10.
PMID: 12855817 [PubMed - indexed for MEDLINE]
0211. Tamai R, Sugawara S, Takeuchi O, Akira S, Takada H.
Synergistic effects of lipopolysaccharide and interferon-gamma in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression.
J Endotoxin Res. 2003;9(3):145-53.
PMID: 12831455 [PubMed - indexed for MEDLINE]
0210. Elhage R, Jawien J, Rudling M, Ljunggren HG, Takeda K, Akira S, Bayard F, Hansson GK.
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice.
Cardiovasc Res. 2003 Jul 1;59(1):234-40.
PMID: 12829194 [PubMed - indexed for MEDLINE]
0209. Sugawara I, Yamada H, Li C, Mizuno S, Takeuchi O, Akira S.
Mycobacterial infection in TLR2 and TLR6 knockout mice.
Microbiol Immunol. 2003;47(5):327-36.
PMID: 12825894 [PubMed - indexed for MEDLINE]
0208. Jouault T, Ibata-Ombetta S, Takeuchi O, Trinel PA, Sacchetti P, Lefebvre P, Akira S, Poulain D.
Candida albicans phospholipomannan is sensed through toll-like receptors.
J Infect Dis. 2003 Jul 1;188(1):165-72. Epub 2003 Jun 23.
PMID: 12825186 [PubMed - indexed for MEDLINE]
0207. Kojima E, Takeuchi A, Haneda M, Yagi A, Hasegawa T, Yamaki K, Takeda K, Akira S, Shimokata K, Isobe K.
The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice.
FASEB J. 2003 Aug;17(11):1573-5. Epub 2003 Jun 3.
PMID: 12824288 [PubMed - indexed for MEDLINE]
0206. Yokozeki H, Wu MH, Sumi K, Igawa K, Miyazaki Y, Katayama I, Takeda K, Akira S, Nishioka K.
Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice.
Clin Exp Immunol. 2003 Jun;132(3):385-92.
PMID: 12780683 [PubMed - indexed for MEDLINE]
0205. Liu N, Ohnishi N, Ni L, Akira S, Bacon KB.
CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells.
Nat Immunol. 2003 Jul;4(7):687-93. Epub 2003 May 25.
PMID: 12766768 [PubMed - indexed for MEDLINE]
0204. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A.
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.
Nat Immunol. 2003 Jun;4(6):551-6. Epub 2003 May 18.
PMID: 12754507 [PubMed - indexed for MEDLINE]
0203. Goldstein DR, Tesar BM, Akira S, Lakkis FG.
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection.
J Clin Invest. 2003 May;111(10):1571-8.
PMID: 12750407 [PubMed - indexed for MEDLINE]
0202. Zwijnenburg PJ, van der Poll T, Florquin S, Akira S, Takeda K, Roord JJ, van Furth AM.
Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis.
J Neuroimmunol. 2003 May;138(1-2):31-7.
PMID: 12742650 [PubMed - indexed for MEDLINE]
0201. Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K, Akira S.
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice.
J Clin Invest. 2003 May;111(9):1297-308.
PMID: 12727921 [PubMed - indexed for MEDLINE]
0200. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM.
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2.
J Exp Med. 2003 May 5;197(9):1107-17. Epub 2003 Apr 28.
PMID: 12719479 [PubMed - indexed for MEDLINE]
0199. Yazawa N, Fujimoto M, Sato S, Miyake K, Asano N, Nagai Y, Takeuchi O, Takeda K, Okochi H, Akira S, Tedder TF, Tamaki K.
CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
Blood. 2003 Aug 15;102(4):1374-80. Epub 2003 Apr 24.
PMID: 12714520 [PubMed - indexed for MEDLINE]
0198. Datta SK, Redecke V, Prilliman KR, Takabayashi K, Corr M, Tallant T, DiDonato J, Dziarski R, Akira S, Schoenberger SP, Raz E.
A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells.
J Immunol. 2003 Apr 15;170(8):4102-10.
PMID: 12682240 [PubMed - indexed for MEDLINE]
0197. Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL.
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.
Nat Med. 2003 May;9(5):525-32. Epub 2003 Apr 14.
PMID: 12692544 [PubMed - indexed for MEDLINE]
0196. Edwards AD, Diebold SS, Slack EM, Tomizawa H, Hemmi H, Kaisho T, Akira S, Reis e Sousa C.
Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.
Eur J Immunol. 2003 Apr;33(4):827-33.
PMID: 12672047 [PubMed - indexed for MEDLINE]
0195. Schultz MJ, Knapp S, Florquin S, Pater J, Takeda K, Akira S, van der Poll T.
Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa.
Infect Immun. 2003 Apr;71(4):1630-4.
PMID: 12654774 [PubMed - indexed for MEDLINE]
0194. Zhang JH, He H, Borzychowski AM, Takeda K, Akira S, Croy BA.
Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells.
Biol Reprod. 2003 Aug;69(2):404-11. Epub 2003 Mar 19.
PMID: 12646495 [PubMed - indexed for MEDLINE]
0193. Hemmi H, Kaisho T, Takeda K, Akira S.
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.
J Immunol. 2003 Mar 15;170(6):3059-64.
PMID: 12626561 [PubMed - indexed for MEDLINE]
0192. Hazeki K, Masuda N, Funami K, Sukenobu N, Matsumoto M, Akira S, Takeda K, Seya T, Hazeki O.
Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.
Eur J Immunol. 2003 Mar;33(3):740-7.
PMID: 12616494 [PubMed - indexed for MEDLINE]
0191. Prinz M, Heikenwalder M, Schwarz P, Takeda K, Akira S, Aguzzi A.
Prion pathogenesis in the absence of Toll-like receptor signalling.
EMBO Rep. 2003 Feb;4(2):195-9.
PMID: 12612611 [PubMed - indexed for MEDLINE]
0190. Okamoto M, Oshikawa T, Tano T, Ohe G, Furuichi S, Nishikawa H, Ahmed SU, Akashi S, Miyake K, Takeuchi O, Akira S, Moriya Y, Matsubara S, Ryoma Y, Saito M, Sato M.
Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432.
J Natl Cancer Inst. 2003 Feb 19;95(4):316-26.
PMID: 12591988 [PubMed - indexed for MEDLINE]
0189. Muraoka O, Xu B, Tsurumaki T, Akira S, Yamaguchi T, Higuchi H.
Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines.
Neurochem Int. 2003 Jun;42(7):591-601.
PMID: 12590942 [PubMed - indexed for MEDLINE]
0188. Tsuji RF, Hoshino K, Noro Y, Tsuji NM, Kurokawa T, Masuda T, Akira S, Nowak B.
Suppression of allergic reaction by lambda-carrageenan: toll-like receptor 4/MyD88-dependent and -independent modulation of immunity.
Clin Exp Allergy. 2003 Feb;33(2):249-58.
PMID: 12580919 [PubMed - indexed for MEDLINE]
0187. Sanjo H, Takeda K, Tsujimura T, Ninomiya-Tsuji J, Matsumoto K, Akira S.
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
Mol Cell Biol. 2003 Feb;23(4):1231-8.
PMID: 12556483 [PubMed - indexed for MEDLINE]
0186. Okuda Y, Takahashi I, Kim JK, Ohta N, Iwatani K, Iijima H, Kai Y, Tamagawa H, Hiroi T, Kweon MN, Kawano S, Takeda K, Akira S, Sasaki Y, Hori M, Kiyono H.
Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells.
Am J Pathol. 2003 Jan;162(1):263-71.
PMID: 12507909 [PubMed - indexed for MEDLINE]
0185. Girard R, Pedron T, Uematsu S, Balloy V, Chignard M, Akira S, Chaby R.
Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2.
J Cell Sci. 2003 Jan 15;116(Pt 2):293-302.
PMID: 12482915 [PubMed - indexed for MEDLINE]