0184. Aosai F, Chen M, Kang HK, Mun HS, Norose K, Piao LX, Kobayashi M, Takeuchi O, Akira S, Yano A.
Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen.
Cell Stress Chaperones. 2002 Oct;7(4):357-64.
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0183. Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S.
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
J Immunol. 2002 Dec 15;169(12):6668-72.
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0182. Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Nature. 2002 Nov 21;420(6913):324-9.
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0181. Chen M, Aosai F, Norose K, Mun HS, Takeuchi O, Akira S, Yano A.
Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice.
J Parasitol. 2002 Oct;88(5):1017-9.
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0180. Nakagawa R, Naka T, Tsutsui H, Fujimoto M, Kimura A, Abe T, Seki E, Sato S, Takeuchi O, Takeda K, Akira S, Yamanishi K, Kawase I, Nakanishi K, Kishimoto T.
SOCS-1 participates in negative regulation of LPS responses.
Immunity. 2002 Nov;17(5):677-87.
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0179. Morr M, Takeuchi O, Akira S, Simon MM, Muhlradt PF.
Differential recognition of structural details of bacterial lipopeptides by toll-like receptors.
Eur J Immunol. 2002 Dec;32(12):3337-47.
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0178. Ogawa T, Asai Y, Hashimoto M, Takeuchi O, Kurita T, Yoshikai Y, Miyake K, Akira S.
Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway.
Int Immunol. 2002 Nov;14(11):1325-32.
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0177. Shimizu H, Matsuguchi T, Fukuda Y, Nakano I, Hayakawa T, Takeuchi O, Akira S, Umemura M, Suda T, Yoshikai Y.
Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice.
Gastroenterology. 2002 Oct;123(4):1265-77.
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0176. Imasato A, Desbois-Mouthon C, Han J, Kai H, Cato AC, Akira S, Li JD.
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2.
J Biol Chem. 2002 Dec 6;277(49):47444-50. Epub 2002 Sep 27.
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0175. Hoshino K, Kaisho T, Iwabe T, Takeuchi O, Akira S.
Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.
Int Immunol. 2002 Oct;14(10):1225-31.
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0174. Hawn TR, Ozinsky A, Underhill DM, Buckner FS, Akira S, Aderem A.
Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway.
Microbes Infect. 2002 Jul;4(8):763-71.
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0173. Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT.
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
J Immunol. 2002 Oct 1;169(7):3970-7.
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0172. Seki E, Tsutsui H, Tsuji NM, Hayashi N, Adachi K, Nakano H, Futatsugi-Yumikura S, Takeuchi O, Hoshino K, Akira S, Fujimoto J, Nakanishi K.
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice.
J Immunol. 2002 Oct 1;169(7):3863-8.
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0171. Edwards AD, Manickasingham SP, Sporri R, Diebold SS, Schulz O, Sher A, Kaisho T, Akira S, Reis e Sousa C.
Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering.
J Immunol. 2002 Oct 1;169(7):3652-60.
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0170. Mallat Z, Silvestre JS, Le Ricousse-Roussanne S, Lecomte-Raclet L, Corbaz A, Clergue M, Duriez M, Barateau V, Akira S, Tedgui A, Tobelem G, Chvatchko Y, Levy BI.
Interleukin-18/interleukin-18 binding protein signaling modulates ischemia-induced neovascularization in mice hindlimb.
Circ Res. 2002 Sep 6;91(5):441-8.
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0169. Yamao T, Noguchi T, Takeuchi O, Nishiyama U, Morita H, Hagiwara T, Akahori H, Kato T, Inagaki K, Okazawa H, Hayashi Y, Matozaki T, Takeda K, Akira S, Kasuga M.
Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.
J Biol Chem. 2002 Oct 18;277(42):39833-9. Epub 2002 Aug 7.
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0168. Tsuboi N, Yoshikai Y, Matsuo S, Kikuchi T, Iwami K, Nagai Y, Takeuchi O, Akira S, Matsuguchi T.
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells.
J Immunol. 2002 Aug 15;169(4):2026-33.
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0167. Konishi H, Tsutsui H, Murakami T, Yumikura-Futatsugi S, Yamanaka K, Tanaka M, Iwakura Y, Suzuki N, Takeda K, Akira S, Nakanishi K, Mizutani H.
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11340-5. Epub 2002 Jul 31.
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0166. Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL.
Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.
J Immunol. 2002 Aug 1;169(3):1535-41.
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0165. Wang T, Lafuse WP, Takeda K, Akira S, Zwilling BS.
Rapid chromatin remodeling of Toll-like receptor 2 promoter during infection of macrophages with Mycobacterium avium.
J Immunol. 2002 Jul 15;169(2):795-801.
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0164. Sato S, Takeuchi O, Fujita T, Tomizawa H, Takeda K, Akira S.
A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways.
Int Immunol. 2002 Jul;14(7):783-91.
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0163. Kaisho T, Hoshino K, Iwabe T, Takeuchi O, Yasui T, Akira S.
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation.
Int Immunol. 2002 Jul;14(7):695-700.
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0162. Suzuki K, Nakajima H, Kagami S, Suto A, Ikeda K, Hirose K, Hiwasa T, Takeda K, Saito Y, Akira S, Iwamoto I.
Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism.
J Exp Med. 2002 Jul 1;196(1):27-38.
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0161. Flo TH, Ryan L, Latz E, Takeuchi O, Monks BG, Lien E, Halaas O, Akira S, Skjak-Braek G, Golenbock DT, Espevik T.
Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
J Biol Chem. 2002 Sep 20;277(38):35489-95. Epub 2002 Jun 27.
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0160. Kinjo Y, Kawakami K, Uezu K, Yara S, Miyagi K, Koguchi Y, Hoshino T, Okamoto M, Kawase Y, Yokota K, Yoshino K, Takeda K, Akira S, Saito A.
Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40.
J Immunol. 2002 Jul 1;169(1):323-9.
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0159. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S.
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
J Immunol. 2002 Jul 1;169(1):10-4.
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0158. Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, Akira S, Kitamura T, Kosugi A, Kimoto M, Miyake K.
Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Nat Immunol. 2002 Jul;3(7):667-72. Epub 2002 Jun 10.
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0157. Kimura-Shimmyo A, Kashiwamura S, Ueda H, Ikeda T, Kanno S, Akira S, Nakanishi K, Mimura O, Okamura H.
Cytokine-induced injury of the lacrimal and salivary glands.
J Immunother. 2002 Mar-Apr;25 Suppl 1:S42-51.
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0156. Ito T, Amakawa R, Kaisho T, Hemmi H, Tajima K, Uehira K, Ozaki Y, Tomizawa H, Akira S, Fukuhara S.
Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets.
J Exp Med. 2002 Jun 3;195(11):1507-12.
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0155. Uematsu S, Matsumoto M, Takeda K, Akira S.
Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway.
J Immunol. 2002 Jun 1;168(11):5811-6.
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0154. Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H.
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.
J Clin Invest. 2002 May;109(10):1351-9.
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0153. Coelho PS, Klein A, Talvani A, Coutinho SF, Takeuchi O, Akira S, Silva JS, Canizzaro H, Gazzinelli RT, Teixeira MM.
Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages.
J Leukoc Biol. 2002 May;71(5):837-44.
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0152. Yamazaki T, Takeda K, Gotoh K, Takeshima H, Akira S, Kurosaki T.
Essential immunoregulatory role for BCAP in B cell development and function.
J Exp Med. 2002 Mar 4;195(5):535-45.
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0151. Shuto T, Imasato A, Jono H, Sakai A, Xu H, Watanabe T, Rixter DD, Kai H, Andalibi A, Linthicum F, Guan YL, Han J, Cato AC, Lim DJ, Akira S, Li JD.
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase.
J Biol Chem. 2002 May 10;277(19):17263-70. Epub 2002 Feb 26.
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0150. Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M.
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.
J Clin Invest. 2002 Feb;109(4):525-32.
PMID: 11854325 [PubMed - indexed for MEDLINE]
0149. Tamai R, Sakuta T, Matsushita K, Torii M, Takeuchi O, Akira S, Akashi S, Espevik T, Sugawara S, Takada H.
Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression.
Infect Immun. 2002 Mar;70(3):1272-8.
PMID: 11854210 [PubMed - indexed for MEDLINE]
0148. Okamoto M, Kato S, Oizumi K, Kinoshita M, Inoue Y, Hoshino K, Akira S, McKenzie AN, Young HA, Hoshino T.
Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia.
Blood. 2002 Feb 15;99(4):1289-98.
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0147. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S.
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Nat Immunol. 2002 Feb;3(2):196-200. Epub 2002 Jan 22.
PMID: 11812998 [PubMed - indexed for MEDLINE]
0146. Schweizer U, Gunnersen J, Karch C, Wiese S, Holtmann B, Takeda K, Akira S, Sendtner M.
Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult.
J Cell Biol. 2002 Jan 21;156(2):287-97. Epub 2002 Jan 21.
PMID: 11807093 [PubMed - indexed for MEDLINE]
0145. Lauw FN, Branger J, Florquin S, Speelman P, van Deventer SJ, Akira S, van der Poll T.
IL-18 improves the early antimicrobial host response to pneumococcal pneumonia.
J Immunol. 2002 Jan 1;168(1):372-8.
PMID: 11751983 [PubMed - indexed for MEDLINE]