0111. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S.
A Toll-like receptor recognizes bacterial DNA.
Nature. 2000 Dec 7;408(6813):740-5. Erratum in: Nature 2001 Feb 1;409(6820):646.
PMID: 11130078 [PubMed - indexed for MEDLINE]
0110. Sato S, Nomura F, Kawai T, Takeuchi O, Muhlradt PF, Takeda K, Akira S.
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways.
J Immunol. 2000 Dec 15;165(12):7096-101.
PMID: 11120839 [PubMed - indexed for MEDLINE]
0109. Inagaki K, Yamao T, Noguchi T, Matozaki T, Fukunaga K, Takada T, Hosooka T, Akira S, Kasuga M.
SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility.
EMBO J. 2000 Dec 15;19(24):6721-31.
PMID: 11118207 [PubMed - indexed for MEDLINE]
0108. Tsuji S, Matsumoto M, Takeuchi O, Akira S, Azuma I, Hayashi A, Toyoshima K, Seya T.
Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of toll-like receptors.
Infect Immun. 2000 Dec;68(12):6883-90.
PMID: 11083809 [PubMed - indexed for MEDLINE]
0107. Takeuchi O, Hoshino K, Akira S.
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.
J Immunol. 2000 Nov 15;165(10):5392-6.
PMID: 11067888 [PubMed - indexed for MEDLINE]
0106. Pien GC, Satoskar AR, Takeda K, Akira S, Biron CA.
Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection.
J Immunol. 2000 Nov 1;165(9):4787-91.
PMID: 11046000 [PubMed - indexed for MEDLINE]
0105. Lu H, Yang X, Takeda K, Zhang D, Fan Y, Luo M, Shen C, Wang S, Akira S, Brunham RC.
Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity.
Mol Med. 2000 Jul;6(7):604-12.
PMID: 10997341 [PubMed - indexed for MEDLINE]
0104. Schnare M, Holt AC, Takeda K, Akira S, Medzhitov R.
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88.
Curr Biol. 2000 Sep 21;10(18):1139-42.
PMID: 10996797 [PubMed - indexed for MEDLINE]
0103. Shi FD, Takeda K, Akira S, Sarvetnick N, Ljunggren HG.
IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells.
J Immunol. 2000 Sep 15;165(6):3099-104.
PMID: 10975822 [PubMed - indexed for MEDLINE]
0102. Hacker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H.
Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.
J Exp Med. 2000 Aug 21;192(4):595-600.
PMID: 10952730 [PubMed - indexed for MEDLINE]
0101. Sakao Y, Kawai T, Takeuchi O, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.
Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting.
Genomics. 2000 Jul 1;67(1):1-7.
PMID: 10945464 [PubMed - indexed for MEDLINE]
0100. Hashimoto A, Takeda K, Inaba M, Sekimata M, Kaisho T, Ikehara S, Homma Y, Akira S, Kurosaki T.
Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function.
J Immunol. 2000 Aug 15;165(4):1738-42.
PMID: 10925250 [PubMed - indexed for MEDLINE]
0099. Kawakami K, Koguchi Y, Qureshi MH, Miyazato A, Yara S, Kinjo Y, Iwakura Y, Takeda K, Akira S, Kurimoto M, Saito A.
IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells.
J Immunol. 2000 Jul 15;165(2):941-7.
PMID: 10878369 [PubMed - indexed for MEDLINE]
0098. Mokuno Y, Matsuguchi T, Takano M, Nishimura H, Washizu J, Ogawa T, Takeuchi O, Akira S, Nimura Y, Yoshikai Y.
Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice.
J Immunol. 2000 Jul 15;165(2):931-40.
PMID: 10878368 [PubMed - indexed for MEDLINE]
0097. Hashimoto M, Imamura Y, Morichika T, Arimoto K, Takeuchi O, Takeda K, Akira S, Aoyama K, Tamura T, Kotani S, Suda Y, Kusumoto S.
Cytokine-inducing macromolecular glycolipids from Enterococcus hirae: improved method for separation and analysis of its effects on cellular activation.
Biochem Biophys Res Commun. 2000 Jun 24;273(1):164-9.
PMID: 10873580 [PubMed - indexed for MEDLINE]
0096. Sansonetti PJ, Phalipon A, Arondel J, Thirumalai K, Banerjee S, Akira S, Takeda K, Zychlinsky A.
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation.
Immunity. 2000 May;12(5):581-90.
PMID: 10843390 [PubMed - indexed for MEDLINE]
0095. Monteforte GM, Takeda K, Rodriguez-Sosa M, Akira S, David JR, Satoskar AR.
Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection.
J Immunol. 2000 Jun 1;164(11):5890-3.
PMID: 10820270 [PubMed - indexed for MEDLINE]
0094. Kawakami K, Koguchi Y, Qureshi MH, Kinjo Y, Yara S, Miyazato A, Kurimoto M, Takeda K, Akira S, Saito A.
Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice.
FEMS Microbiol Lett. 2000 May 1;186(1):121-6.
PMID: 10779723 [PubMed - indexed for MEDLINE]
0093. Ohkusu K, Yoshimoto T, Takeda K, Ogura T, Kashiwamura S, Iwakura Y, Akira S, Okamura H, Nakanishi K.
Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection.
Infect Immun. 2000 May;68(5):2449-56.
PMID: 10768930 [PubMed - indexed for MEDLINE]
0092. Nomura F, Kawai T, Nakanishi K, Akira S.
NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.
Genes Cells. 2000 Mar;5(3):191-202.
PMID: 10759890 [PubMed - indexed for MEDLINE]
0091. Yokozeki H, Ghoreishi M, Takagawa S, Takayama K, Satoh T, Katayama I, Takeda K, Akira S, Nishioka K.
Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity.
J Exp Med. 2000 Mar 20;191(6):995-1004.
PMID: 10727461 [PubMed - indexed for MEDLINE]
0090. Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, Nakanishi K, Kimoto M, Miyake K, Takeda K, Akira S.
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.
J Immunol. 2000 Apr 1;164(7):3476-9.
PMID: 10725699 [PubMed - indexed for MEDLINE]
0089. Kawakami K, Qureshi MH, Zhang T, Koguchi Y, Yara S, Takeda K, Akira S, Kurimoto M, Saito A.
Involvement of endogenously synthesized interleukin (IL)-18 in the protective effects of IL-12 against pulmonary infection with Cryptococcus neoformans in mice.
FEMS Immunol Med Microbiol. 2000 Mar;27(3):191-200.
PMID: 10683463 [PubMed - indexed for MEDLINE]
0088. Takeuchi S, Takeda K, Oishi I, Nomi M, Ikeya M, Itoh K, Tamura S, Ueda T, Hatta T, Otani H, Terashima T, Takada S, Yamamura H, Akira S, Minami Y.
Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.
Genes Cells. 2000 Jan;5(1):71-8.
PMID: 10651906 [PubMed - indexed for MEDLINE]
0087. Kodama T, Matsuyama T, Kuribayashi K, Nishioka Y, Sugita M, Akira S, Nakanishi K, Okamura H.
IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice.
J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):45-53.
PMID: 10629451 [PubMed - indexed for MEDLINE]
0086. Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, Muhlradt PF, Akira S.
Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway.
J Immunol. 2000 Jan 15;164(2):554-7.
PMID: 10623793 [PubMed - indexed for MEDLINE]
0085. Takeuchi O, Takeda K, Hoshino K, Adachi O, Ogawa T, Akira S.
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades.
Int Immunol. 2000 Jan;12(1):113-7.
PMID: 10607756 [PubMed - indexed for MEDLINE]
0084. Okuda T, Takeda K, Fujita Y, Nishimura M, Yagyu S, Yoshida M, Akira S, Downing JR, Abe T.
Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy.
Mol Cell Biol. 2000 Jan;20(1):319-28.
PMID: 10594034 [PubMed - indexed for MEDLINE]