0083. Kaisho T, Tsutsui H, Tanaka T, Tsujimura T, Takeda K, Kawai T, Yoshida N, Nakanishi K, Akira S.
Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice.
J Exp Med. 1999 Dec 6;190(11):1573-82.
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0082. Hayashi N, Matsui K, Tsutsui H, Osada Y, Mohamed RT, Nakano H, Kashiwamura S, Hyodo Y, Takeda K, Akira S, Hada T, Higashino K, Kojima S, Nakanishi K.
Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens.
J Immunol. 1999 Dec 15;163(12):6702-11.
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0081. Yoshimoto T, Tsutsui H, Tominaga K, Hoshino K, Okamura H, Akira S, Paul WE, Nakanishi K.
IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils.
Proc Natl Acad Sci USA. 1999 Nov 23;96(24):13962-6.
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0080. Hoshino K, Kashiwamura S, Kuribayashi K, Kodama T, Tsujimura T, Nakanishi K, Matsuyama T, Takeda K, Akira S.
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and itseffector function.
J Exp Med. 1999 Nov 15;190(10):1541-8.
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0079. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S.
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Immunity. 1999 Oct;11(4):443-51.
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0078. Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Akira S.
A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
J Immunol. 1999 Nov 1;163(9):5039-48.
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0077. Chapman RS, Lourenco PC, Tonner E, Flint DJ, Selbert S, Takeda K, Akira S, Clarke AR, Watson CJ.
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.
Genes Dev. 1999 Oct 1;13(19):2604-16.
PMID: 10521404 [PubMed - indexed for MEDLINE]
0076. Tsutsui H, Kayagaki N, Kuida K, Nakano H, Hayashi N, Takeda K, Matsui K, Kashiwamura S, Hada T, Akira S, Yagita H, Okamura H, Nakanishi K.
Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.
Immunity. 1999 Sep;11(3):359-67.
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0075. Sano S, Itami S, Takeda K, Tarutani M, Yamaguchi Y, Miura H, Yoshikawa K, Akira S, Takeda J.
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis.
EMBO J. 1999 Sep 1;18(17):4657-68.
PMID: 10469645 [PubMed - indexed for MEDLINE]
0074. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S.
Unresponsiveness of MyD88-deficient mice to endotoxin.
Immunity. 1999 Jul;11(1):115-22.
PMID: 10435584 [PubMed - indexed for MEDLINE]
0073. Matsui H, Ihara Y, Fujio Y, Kunisada K, Akira S, Kishimoto T, Yamauchi-Takihara K.
Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes.
Cardiovasc Res. 1999 Apr;42(1):104-12.
PMID: 10435001 [PubMed - indexed for MEDLINE]
0072. Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S.
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
Int Immunol. 1999 Aug;11(8):1357-62.
PMID: 10421793 [PubMed - indexed for MEDLINE]
0071. Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S.
Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
Oncogene. 1999 Jun 10;18(23):3471-80.
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0070. Yukawa K, Tanaka T, Tsuji S, Akira S.
Regulation of transcription factor C/ATF by the cAMP signal activation in hippocampal neurons, and molecular interaction of C/ATF with signal integrator CBP/p300.
Brain Res Mol Brain Res. 1999 May 21;69(1):124-34.
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0069. Riley JK, Takeda K, Akira S, Schreiber RD.
Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action.
J Biol Chem. 1999 Jun 4;274(23):16513-21.
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0068. Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.
TLR6: A novel member of an expanding toll-like receptor family.
Gene. 1999 Apr 29;231(1-2):59-65.
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0067. Oishi I, Takeuchi S, Hashimoto R, Nagabukuro A, Ueda T, Liu ZJ, Hatta T, Akira S, Matsuda Y, Yamamura H, Otani H, Minami Y.
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.
Genes Cells. 1999 Jan;4(1):41-56.
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0066. Hoshino K, Tsutsui H, Kawai T, Takeda K, Nakanishi K, Takeda Y, Akira S.
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.
J Immunol. 1999 May 1;162(9):5041-4.
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0065. Sugawara I, Yamada H, Kaneko H, Mizuno S, Takeda K, Akira S.
Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice.
Infect Immun. 1999 May;67(5):2585-9.
PMID: 10225924 [PubMed - indexed for MEDLINE]
0064. Sakao Y, Takeda K, Tsutsui H, Kaisho T, Nomura F, Okamura H, Nakanishi K, Akira S.
IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock.
Int Immunol. 1999 Mar;11(3):471-80.
PMID: 10221659 [PubMed - indexed for MEDLINE]
0063. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S.
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.
J Immunol. 1999 Apr 1;162(7):3749-52.
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0062. Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S.
Limb and skin abnormalities in mice lacking IKKalpha.
Science. 1999 Apr 9;284(5412):313-6.
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0061. Pizarro-Cerda J, Desjardins M, Moreno E, Akira S, Gorvel JP.
Modulation of endocytosis in nuclear factor IL-6(-/-) macrophages is responsible for a high susceptibility to intracellular bacterial infection.
J Immunol. 1999 Mar 15;162(6):3519-26.
PMID: 10092809 [PubMed - indexed for MEDLINE]
0060. Mizoguchi C, Uehara S, Akira S, Takatsu K.
IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes.
J Immunol. 1999 Mar 1;162(5):2812-9.
PMID: 10072528 [PubMed - indexed for MEDLINE]
0059. Miyata S, Matsuyama T, Kodama T, Nishioka Y, Kuribayashi K, Takeda K, Akira S, Sugita M.
STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells.
Clin Exp Allergy. 1999 Jan;29(1):114-23.
PMID: 10051710 [PubMed - indexed for MEDLINE]
0058. Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, Forster I, Akira S.
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.
Immunity. 1999 Jan;10(1):39-49.
PMID: 10023769 [PubMed - indexed for MEDLINE]
0057. Kawai T, Sanjo H, Akira S.
Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.
Gene. 1999 Feb 18;227(2):249-55.
PMID: 10023074 [PubMed - indexed for MEDLINE]
0056. Hyodo Y, Matsui K, Hayashi N, Tsutsui H, Kashiwamura S, Yamauchi H, Hiroishi K, Takeda K, Tagawa Y, Iwakura Y, Kayagaki N, Kurimoto M, Okamura H, Hada T, Yagita H, Akira S, Nakanishi K, Higashino K.
IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor.
J Immunol. 1999 Feb 1;162(3):1662-8.
PMID: 9973427 [PubMed - indexed for MEDLINE]