0055. Tanaka T, Tsujimura T, Takeda K, Sugihara A, Maekawa A, Terada N, Yoshida N, Akira S.
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.
Genes Cells. 1998 Dec;3(12):801-10.
PMID: 10096021 [PubMed - indexed for MEDLINE]
0054. Matsumoto M, Sakao Y, Akira S.
Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line.
Int Immunol. 1998 Dec;10(12):1825-35.
PMID: 9885903 [PubMed - indexed for MEDLINE]
0053. Akaishi H, Takeda K, Kaisho T, Shineha R, Satomi S, Takeda J, Akira S.
Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes.
Int Immunol. 1998 Nov;10(11):1747-51.
PMID: 9846704 [PubMed - indexed for MEDLINE]
0052. Yukawa K, Tanaka T, Tsuji S, Akira S.
Expressions of CCAAT/Enhancer-binding proteins beta and delta and their activities are intensified by cAMP signaling as well as Ca2+/calmodulin kinases activation in hippocampal neurons.
J Biol Chem. 1998 Nov 20;273(47):31345-51.
PMID: 9813043 [PubMed - indexed for MEDLINE]
0051. Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S.
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.
J Immunol. 1998 Nov 1;161(9):4652-60.
PMID: 9794394 [PubMed - indexed for MEDLINE]
0050. Sanjo H, Kawai T, Akira S.
DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis.
J Biol Chem. 1998 Oct 30;273(44):29066-71.
PMID: 9786912 [PubMed - indexed for MEDLINE]
0049. Yoshimoto T, Takeda K, Tanaka T, Ohkusu K, Kashiwamura S, Okamura H, Akira S, Nakanishi K.
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.
J Immunol. 1998 Oct 1;161(7):3400-7.
PMID: 9759857 [PubMed - indexed for MEDLINE]
0048. Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S.
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Immunity. 1998 Jul;9(1):143-50.
PMID: 9697844 [PubMed - indexed for MEDLINE]
0047. Akimoto T, Numata F, Tamura M, Takata Y, Higashida N, Takashi T, Takeda K, Akira S.
Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice.
J Exp Med. 1998 May 4;187(9):1537-42.
PMID: 9565645 [PubMed - indexed for MEDLINE]
0046. Shimada T, Matsumoto M, Tatsumi Y, Kanamaru A, Akira S.
A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages.
FEBS Lett. 1998 Apr 3;425(3):490-4.
PMID: 9563519 [PubMed - indexed for MEDLINE]
0045. Stephanou A, Isenberg DA, Akira S, Kishimoto T, Latchman DS.
The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat shock.
Biochem J. 1998 Feb 15;330 ( Pt 1):189-95.
PMID: 9461509 [PubMed - indexed for MEDLINE]
0044. Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, Okamura H, Nakanishi K, Akira S.
Defective NK cell activity and Th1 response in IL-18-deficient mice.
Immunity. 1998 Mar;8(3):383-90.
PMID: 9529155 [PubMed - indexed for MEDLINE]
0043. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Mol Cell Biol. 1998 Mar;18(3):1642-51.
PMID: 9488481 [PubMed - indexed for MEDLINE]
0042. Tanaka T, Yoshida N, Kishimoto T, Akira S.
Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene.
EMBO J. 1997 Dec 15;16(24):7432-43.
PMID: 9405372 [PubMed - indexed for MEDLINE]
0041. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T.
Structure and function of a new STAT-induced STAT inhibitor.
Nature. 1997 Jun 26;387(6636):924-9.
PMID: 9202127 [PubMed - indexed for MEDLINE]
0040. Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, Kishimoto T, Akira S.
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3801-4.
PMID: 9108058 [PubMed - indexed for MEDLINE]
0039. Inoue M, Minami M, Matsumoto M, Kishimoto T, Akira S.
The amino acid residues immediately carboxyl-terminal to the tyrosine phosphorylation site contribute to interleukin 6-specific activation of signal transducer and activator of transcription 3.
J Biol Chem. 1997 Apr 4;272(14):9550-5.
PMID: 9083098 [PubMed - indexed for MEDLINE]
0038. Kurebayashi S, Miyashita Y, Hirose T, Kasayama S, Akira S, Kishimoto T.
Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor.
J Steroid Biochem Mol Biol. 1997 Jan;60(1-2):11-7.
PMID: 9182853 [PubMed - indexed for MEDLINE]
0037. Stephanou A, Amin V, Isenberg DA, Akira S, Kishimoto T, Latchman DS.
Interleukin 6 activates heat-shock protein 90 beta gene expression.
Biochem J. 1997 Jan 1;321 ( Pt 1):103-6.
PMID: 9003407 [PubMed - indexed for MEDLINE]
0036. Matsumoto M, Minami M, Takeda K, Sakao Y, Akira S.
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells.
FEBS Lett. 1996 Oct 21;395(2-3):143-7.
PMID: 8898082 [PubMed - indexed for MEDLINE]
0035. Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S.
Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.
J Immunol. 1996 Oct 15;157(8):3220-2.
PMID: 8871614 [PubMed - indexed for MEDLINE]
0034. Shi W, Inoue M, Minami M, Takeda K, Matsumoto M, Matsuda Y, Kishimoto T, Akira S.
The genomic structure and chromosomal localization of the mouse STAT3 gene.
Int Immunol. 1996 Aug;8(8):1205-11.
PMID: 8918689 [PubMed - indexed for MEDLINE]
0033. Yu CR, Lin JX, Fink DW, Akira S, Bloom ET, Yamauchi A.
Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.
J Immunol. 1996 Jul 1;157(1):126-37.
PMID: 8683106 [PubMed - indexed for MEDLINE]
0032. Liu D, Li Z, Akira S, Kishimoto T.
Overexpression of a reversion-related protein in the revertant RR cells.
Sci China C Life Sci. 1996 Jun;39(3):300-9.
PMID: 8760458 [PubMed - indexed for MEDLINE]
0031. Minami M, Inoue M, Wei S, Takeda K, Matsumoto M, Kishimoto T, Akira S.
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3963-6.
PMID: 8632998 [PubMed - indexed for MEDLINE]
0030. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S.
Essential role of Stat6 in IL-4 signalling.
Nature. 1996 Apr 18;380(6575):627-30.
PMID: 8602263 [PubMed - indexed for MEDLINE]
0029. Sugiyama T, Nishio Y, Kishimoto T, Akira S.
Identification of alternative splicing form of Stat2.
FEBS Lett. 1996 Mar 4;381(3):191-4.
PMID: 8601453 [PubMed - indexed for MEDLINE]
0028. Toda K, Akira S, Kishimoto T, Sasaki H, Hashimoto K, Yamamoto Y, Sagara Y, Shizuta Y.
Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family.
Eur J Biochem. 1995 Jul 15;231(2):292-9.
PMID: 7635140 [PubMed - indexed for MEDLINE]
0027. Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T.
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.
Cell. 1995 Jan 27;80(2):353-61.
PMID: 7530603 [PubMed - indexed for MEDLINE]
0026. Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T.
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
Cell. 1994 Apr 8;77(1):63-71.
PMID: 7512451 [PubMed - indexed for MEDLINE]
0025. Betts JC, Cheshire JK, Akira S, Kishimoto T, Woo P.
The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and nterleukin-6.
J Biol Chem. 1993 Dec 5;268(34):25624-31.
PMID: 8244997 [PubMed - indexed for MEDLINE]
0024. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S.
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10193-7.
PMID: 8234276 [PubMed - indexed for MEDLINE]
0023. Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T, Akira S.
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2207-11.
PMID: 8384717 [PubMed - indexed for MEDLINE]
0022. Nishio Y, Isshiki H, Kishimoto T, Akira S.
A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction.
Mol Cell Biol. 1993 Mar;13(3):1854-62.
PMID: 8441418 [PubMed - indexed for MEDLINE]
0021. Kyo S, Inoue M, Nishio Y, Nakanishi K, Akira S, Inoue H, Yutsudo M, Tanizawa O, Hakura A.
NF-IL6 represses early gene expression of human papillomavirus type 16 through binding to the noncoding region.
J Virol. 1993 Feb;67(2):1058-66.
PMID: 8380454 [PubMed - indexed for MEDLINE]
0020. Kinoshita S, Akira S, Kishimoto T.
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1473-6.
PMID: 1741402 [PubMed - indexed for MEDLINE]
0019. Spergel JM, Hsu W, Akira S, Thimmappaya B, Kishimoto T, Chen-Kiang S.
NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A.
J Virol. 1992 Feb;66(2):1021-30.
PMID: 1309887 [PubMed - indexed for MEDLINE]
0018. Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, Kishimoto T.
Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6.
Blood. 1992 Jan 15;79(2):460-6.
PMID: 1730090 [PubMed - indexed for MEDLINE]
0017. Natsuka S, Isshiki H, Akira S, Kishimoto T.
Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL6.
FEBS Lett. 1991 Oct 7;291(1):58-62.
PMID: 1718780 [PubMed - indexed for MEDLINE]
0016. Tang B, Matsuda T, Akira S, Nagata N, Ikehara S, Hirano T, Kishimoto T.
Age-associated increase in interleukin 6 in MRL/lpr mice.
Int Immunol. 1991 Mar;3(3):273-8.
PMID: 2049341 [PubMed - indexed for MEDLINE]
0015. Isshiki H, Akira S, Sugita T, Nishio Y, Hashimoto S, Pawlowski T, Suematsu�@S, Kishimoto T.
Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression.
New Biol. 1991 Jan;3(1):63-70.
PMID: 1710143 [PubMed - indexed for MEDLINE]
0014. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T.
A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.
EMBO J. 1990 Jun;9(6):1897-906.
PMID: 2112087 [PubMed - indexed for MEDLINE]
0013. Isshiki H, Akira S, Tanabe O, Nakajima T, Shimamoto T, Hirano T, Kishimoto T.
Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.
Mol Cell Biol. 1990 Jun;10(6):2757-64.
PMID: 2111442 [PubMed - indexed for MEDLINE]
0012. Suematsu S, Matsuda T, Aozasa K, Akira S, Nakano N, Ohno S, Miyazaki J, Yamamura K, Hirano T, Kishimoto T.
IgG1 plasmacytosis in interleukin 6 transgenic mice.
Proc Natl Acad Sci U S A. 1989 Oct;86(19):7547-51.
PMID: 2798426 [PubMed - indexed for MEDLINE]
0011. Tanabe O, Akira S, Kamiya T, Wong GG, Hirano T, Kishimoto T.
Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.
J Immunol. 1988 Dec 1;141(11):3875-81.
PMID: 3263439 [PubMed - indexed for MEDLINE]
0010. Aguilera RJ, Akira S, Okazaki K, Sakano H.
A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences.
Cell. 1987 Dec 24;51(6):909-17.
PMID: 3500792 [PubMed - indexed for MEDLINE]
0009. Akira S, Okazaki K, Sakano H.
Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining.
Science. 1987 Nov 20;238(4830):1134-8.
PMID: 3120312 [PubMed - indexed for MEDLINE]
0008. Sugiyama H, Maeda T, Akira S, Kishimoto S.
Class-switching from mu to gamma 3 or gamma 2b production at pre-B cell stage.
J Immunol. 1986 Apr 15;136(8):3092-7.
PMID: 3082980 [PubMed - indexed for MEDLINE]
0007. Yamamura K, Kikutani H, Folsom V, Clayton LK, Kimoto M, Akira S, Kashiwamura S, Tonegawa S, Kishimoto T.
Functional expression of a microinjected Ed alpha gene in C57BL/6 transgenic mice.
Nature. 1985 Jul 4-10;316(6023):67-9.
PMID: 2409451 [PubMed - indexed for MEDLINE]
0006. Kikutani H, Taga T, Akira S, Kishi H, Miki Y, Saiki O, Yamamura Y, Kishimoto T.
Effect of B cell differentiation factor (BCDF) on biosynthesis and secretion of immunoglobulin molecules in human B cell lines.
J Immunol. 1985 Feb;134(2):990-5.
PMID: 3917482 [PubMed - indexed for MEDLINE]
0005. Yamamura K, Kikutani H, Takahashi N, Taga T, Akira S, Kawai K, Fukuchi K, Kumahara Y, Honjo T, Kishimoto T.
Introduction of human gamma 1 immunoglobulin genes into fertilized mouse eggs.
J Biochem. 1984 Aug;96(2):357-63.
PMID: 6094517 [PubMed - indexed for MEDLINE]
0004. Akira S, Sugiyama H, Sakaguchi N, Kishimoto T.
Immunoglobulin gene expression and DNA methylation in murine pre-B cell lines.
EMBO J. 1984 Mar;3(3):677-81.
PMID: 6425058 [PubMed - indexed for MEDLINE]
0003. Akira S, Sugiyama H, Yoshida N, Kikutani H, Yamamura Y, Kishimoto T.
Isotype switching in murine pre-B cell lines.
Cell. 1983 Sep;34(2):545-56.
PMID: 6311431 [PubMed - indexed for MEDLINE]
0002. Sugiyama H, Akira S, Kikutani H, Kishimoto S, Yamamura Y, Kishimoto T.
Functional V region formation during in vitro culture of a murine immature B precursor cell line.
Nature. 1983 Jun 30;303(5920):812-5.
PMID: 6408480 [PubMed - indexed for MEDLINE]
0001. Sugiyama H, Akira S, Yoshida N, Kishimoto S, Yamamura Y, Kincade P, Honjo T, Kishimoto T.
Relationship between the rearrangement of immunoglobulin genes, the appearance of a B lymphocyte antigen, and immunoglobulin synthesis in murine pre-B cell lines.
J Immunol. 1982 Jun;128(6):2793-7.
PMID: 6281337 [PubMed - indexed for MEDLINE]