Saitoh T, Komano J, Saitoh Y. Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoyo N, Akira S.

Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.

Cell Host Microbe. 2012 Jul 19; 12(1):109-116.



Maruyama K, Kawagoe T, Kondo T, Akira S, Takeuchi O.

TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.

J Biol Chem. 2012 Jul 6. [Epub ahead of print]



Kondo T, Kawai T, Akira S.

Dissecting negative regulation of Toll-like receptor signaling.

Trends Immunol. 2012 Jun 19.[Epub ahead of print]



Teraguchi S, Kumagai Y, Vandenbon A, Akira S, Standley DM.

Stochastic binary modeling of cells in continuous time as an alternative to biodhemical reaction equations.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Dec; 84(6 Pt 1):062903. Epub 2011 Dec 15.



Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.
Nat Immunol. 2011 Oct 30. doi: 10.1038/ni.2137. [Epub ahead of print]
PMID: 22037600


Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S.
A New Subset of CD103+CD8{alpha}+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity.
J Immunol. 2011 Apr 27. [Epub ahead of print]
PMID: 21525388


Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.
Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells.
Immunity. 2011 Mar 25;34(3):352-63.
PMID: 21435586 [PubMed - in process]


Kumar H, Pandey S, Zou J, Kumagai Y, Takahashi K, Akira S, Kawai T.
NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections.
J Immunol. 2010 Dec 8. [Epub ahead of print]
PMID: 21148033 [PubMed - as supplied by publisher]


Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S.
The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA.
Immunity. 2010 Nov 10. [Epub ahead of print]
PMID: 21074459 [PubMed - as supplied by publisher]


Miyake T, Satoh T, Kato H, Matsushita K, Kumagai Y, Vandenbon A, Tani T, Muta T, Akira S, Takeuchi O.
I{kappa}B{zeta} is essential for natural killer cell activation in response to IL-12 and IL-18.
Proc Natl Acad Sci U S A. 2010 Sep 27. [Epub ahead of print]
PMID: 20876105


Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S.
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.
Nat Immunol. 2010 Aug 22. [Epub ahead of print]
PMID: 20729857 [PubMed - as supplied by publisher]


Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nuñez G, Ishii KJ, Akira S.
Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.
Cell Host Microbe. 2010 Jan 21;7(1):50-61.
PMID: 20114028


Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O.
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
Proc Natl Acad Sci U S A. 2010 Jan 8. [Epub ahead of print]
PMID: 20080593


Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T.
Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal {beta}-Glucan.
J Immunol. 2009 Dec 15;183(12):8061-8067.
PMID: 20007575

0096. Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S. 
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. 
Proc Natl Acad Sci U S A. 2009 Nov 19. [Epub ahead of print] 
PMID: 19926846
0095. Kawagoe T*, Takeuchi O*, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S. 
*contributed equally 
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. 
Nat Immunol. 2009 Aug 9. [Epub ahead of print] 
PMID: 19668221
0094. Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S. 
Poly I:C-Induced Activation of NK Cells by CD8{alpha}+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways. 
J Immunol. 2009 Jul 27. [Epub ahead of print] 
PMID: 19635904
0093. Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S.
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.
Nature. 2009 Mar 25. [Epub ahead of print]
PMID: 19322177 [PubMed - as supplied by publisher]
0092. Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S.
Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.
J Immunol. 2009 Apr 1;182(7):3960-4.
PMID: 19299691 [PubMed - in process]
0091. Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Nature. 2008 Nov 13;456(7219):264-8. Epub 2008 Oct 5.
PMID: 18849965 [PubMed - indexed for MEDLINE]
0090. Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, Hiiragi A, Dermody TS, Fujita T, Akira S.
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
J Exp Med. 2008 Jul 7;205(7):1601-10.
PMID: 18591409 [PubMed - indexed for MEDLINE]
0089. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S.
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Nat Immunol. 2008 Jul;9(7):769-76. Epub 2008 May 30.
PMID: 18516037 [PubMed - indexed for MEDLINE]
0088. Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S.
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
Nat Immunol. 2008 Jun;9(6):684-91. Epub 2008 Apr 27.
PMID: 18438411 [PubMed - indexed for MEDLINE]
0087. Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S.
TANK-inding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Nature. 2008 Feb 7;451(7179):725-9.
PMID: 18256672 [PubMed - indexed for MEDLINE]
0086. Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S.
Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses.
J Immunol. 2008 Jan 15;180(2):683-7.
PMID: 18178804 [PubMed - indexed for MEDLINE]
0085. Bhattacharjee RN, Park KS, Chen X, Iida T, Honda T, Takeuchi O, Akira S.
Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling.
J Microbiol Biotechnol. 2008 Jan;18(1):171-5.
PMID: 18239436 [PubMed - indexed for MEDLINE]
0084. Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, Akira S.
Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.
J Virol. 2008 Jan;82(1):196-206. Epub 2007 Oct 17.
PMID: 17942529 [PubMed - indexed for MEDLINE]
0083. Uematsu S, Kaisho T, Tanaka T, Matsumoto M, Yamakami M, Omori H, Yamamoto M, Yoshimori T, Akira S.
The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.
J Immunol. 2007 Oct 15;179(8):5378-86.
PMID: 17911624 [PubMed - indexed for MEDLINE]
0082. Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S.
Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.
J Immunol. 2007 Oct 1;179(7):4711-20.
PMID: 17878370 [PubMed - indexed for MEDLINE]
0081. Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, AkiraS.
Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
J Exp Med. 2007 Sep 3;204(9):2233-9. Epub 2007 Aug 27.
PMID: 17724128 [PubMed - indexed for MEDLINE]
0080. Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa K, Kawai T, Akira S.
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Immunity. 2007 Aug;27(2):240-52.
PMID: 17723216 [PubMed - indexed for MEDLINE]
0079. Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira S.
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.
J Exp Med. 2007 May 14;204(5):1013-24. Epub 2007 May 7.
PMID: 17485511 [PubMed - indexed for MEDLINE]
0078. Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S.
Pathological role of Toll-like receptor signaling in cerebral malaria.
Int Immunol. 2007 Jan;19(1):67-79. Epub 2006 Nov 29.
PMID: 17135446 [PubMed - indexed for MEDLINE]
0077. Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S.
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
J Immunol. 2006 Dec 1;177(11):7520-4.
PMID: 17114420 [PubMed - indexed for MEDLINE]
0076. Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S.
VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.
J Biol Chem. 2006 Dec 1;281(48):36897-904. Epub 2006 Sep 19.
PMID: 16984916 [PubMed - indexed for MEDLINE]
0075. Matsui K, Kumagai Y, Kato H, Sato S, Kawagoe T, Uematsu S, Takeuchi O, Akira S.
Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.
J Immunol. 2006 Nov 1;177(9):5785-9.
PMID: 17056502 [PubMed - indexed for MEDLINE]
0074. Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S.
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
Int Immunol. 2006 Oct;18(10):1405-11. Epub 2006 Aug 28.
PMID: 16940043 [PubMed - indexed for MEDLINE]
0073. Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Nat Immunol. 2006 Sep;7(9):962-70. Epub 2006 Jul 23.
PMID: 16862162 [PubMed - indexed for MEDLINE]
0072. Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S.
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
Nat Immunol. 2006 Aug;7(8):868-74. Epub 2006 Jul 9.
PMID: 16829963 [PubMed - indexed for MEDLINE]
0071. Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S.
Essential role of IPS-1 in innate immune responses against RNA viruses.
J Exp Med. 2006 Jul 10;203(7):1795-803. Epub 2006 Jun 19.
PMID: 16785313 [PubMed - indexed for MEDLINE]
0070. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S.
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Nature. 2006 May 4;441(7089):101-5. Epub 2006 Apr 9.
PMID: 16625202 [PubMed - indexed for MEDLINE]
0069. Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S.
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA.
J Immunol. 2006 Apr 15;176(8):4520-4.
PMID: 16585540 [PubMed - indexed for MEDLINE]
0068. Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S.
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Nat Immunol. 2006 Jan;7(1):40-8. Epub 2005 Nov 13. Erratum in: Nat Immunol. 2006 Apr;7(4):427.
PMID: 16286919 [PubMed - indexed for MEDLINE]
0067. Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S.
Essential function for the kinase TAK1 in innate and adaptive immune responses.
Nat Immunol. 2005 Nov;6(11):1087-95. Epub 2005 Sep 25.
PMID: 16186825 [PubMed - indexed for MEDLINE]
0066. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S.
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Nat Immunol. 2005 Oct;6(10):981-8. Epub 2005 Aug 28.
PMID: 16127453 [PubMed - indexed for MEDLINE]
0065. Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S.
Cell type-specific involvement of RIG-I in antiviral response.
Immunity. 2005 Jul;23(1):19-28.
PMID: 16039576 [PubMed - indexed for MEDLINE]
0064. Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S.
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
J Exp Med. 2005 Mar 21;201(6):915-23. Epub 2005 Mar 14.
PMID: 15767370 [PubMed - indexed for MEDLINE]
0063. Hirotani T, Yamamoto M, Kumagai Y, Uematsu S, Kawase I, Takeuchi O, Akira S.
Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.
Biochem Biophys Res Commun. 2005 Mar 11;328(2):383-92.
PMID: 15694359 [PubMed - indexed for MEDLINE]
0062. Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S.
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
J Exp Med. 2005 Jan 3;201(1):19-25.
PMID: 15630134 [PubMed - indexed for MEDLINE]
0061. Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue J, Uematsu S, Takeuchi O, Akira S.
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
Nat Immunol. 2004 Oct;5(10):1061-8. Epub 2004 Sep 7.
PMID: 15361868 [PubMed - indexed for MEDLINE]
0060. Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S.
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.
Nature. 2004 Jul 8;430(6996):218-22.
PMID: 15241416 [PubMed - indexed for MEDLINE]
0059. Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S.
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
J Exp Med. 2004 Jun 21;199(12):1641-50.
PMID: 15210742 [PubMed - indexed for MEDLINE]
0058. Kuwata H, Watanabe Y, Miyoshi H, Yamamoto M, Kaisho T, Takeda K, Akira S.
IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages.
Blood. 2003 Dec 1;102(12):4123-9. Epub 2003 Aug 7.
PMID: 12907458 [PubMed - indexed for MEDLINE]
0057. Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
Nat Immunol. 2003 Nov;4(11):1144-50. Epub 2003 Oct 12.
PMID: 14556004 [PubMed - indexed for MEDLINE]
0056. Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S.
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.
J Immunol. 2003 Oct 15;171(8):4304-10.
PMID: 14530355 [PubMed - indexed for MEDLINE]
0055. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Science. 2003 Aug 1;301(5633):640-3. Epub 2003 Jul 10.
PMID: 12855817 [PubMed - indexed for MEDLINE]
0054. Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K, Akira S.
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice.
J Clin Invest. 2003 May;111(9):1297-308.
PMID: 12727921 [PubMed - indexed for MEDLINE]
0053. Hemmi H, Kaisho T, Takeda K, Akira S.
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.
J Immunol. 2003 Mar 15;170(6):3059-64.
PMID: 12626561 [PubMed - indexed for MEDLINE]
0052. Sanjo H, Takeda K, Tsujimura T, Ninomiya-Tsuji J, Matsumoto K, Akira S.
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
Mol Cell Biol. 2003 Feb;23(4):1231-8.
PMID: 12556483 [PubMed - indexed for MEDLINE]
0051. Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S.
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
J Immunol. 2002 Dec 15;169(12):6668-72.
PMID: 12471095 [PubMed - indexed for MEDLINE]
0050. Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Nature. 2002 Nov 21;420(6913):324-9.
PMID: 12447441 [PubMed - indexed for MEDLINE]
0049. Hoshino K, Kaisho T, Iwabe T, Takeuchi O, Akira S.
Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.
Int Immunol. 2002 Oct;14(10):1225-31.
PMID: 12356687 [PubMed - indexed for MEDLINE]
0048. Sato S, Takeuchi O, Fujita T, Tomizawa H, Takeda K, Akira S.
A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways.
Int Immunol. 2002 Jul;14(7):783-91.
PMID: 12096038 [PubMed - indexed for MEDLINE]
0047. Kaisho T, Hoshino K, Iwabe T, Takeuchi O, Yasui T, Akira S.
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation.
Int Immunol. 2002 Jul;14(7):695-700.
PMID: 12096028 [PubMed - indexed for MEDLINE]
0046. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S.
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
J Immunol. 2002 Jul 1;169(1):10-4.
PMID: 12077222 [PubMed - indexed for MEDLINE]
0045. Uematsu S, Matsumoto M, Takeda K, Akira S.
Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway.
J Immunol. 2002 Jun 1;168(11):5811-6.
PMID: 12023384 [PubMed - indexed for MEDLINE]
0044. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S.
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Nat Immunol. 2002 Feb;3(2):196-200. Epub 2002 Jan 22.
PMID: 11812998 [PubMed - indexed for MEDLINE]
0043. Kawai T, Takeuchi O, Fujita T, Inoue J, M?hlradt PF, Sato S, Hoshino K, Akira S.
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.
J Immunol. 2001 Nov 15;167(10):5887-94.
PMID: 11698465 [PubMed - indexed for MEDLINE]
0042. Takeuchi O, Kawai T, M?hlradt PF, Morr M, Radolf JD, Zychlinsky A, Takeda K, Akira S.
Discrimination of bacterial lipoproteins by Toll-like receptor 6.
Int Immunol. 2001 Jul;13(7):933-40.
PMID: 11431423 [PubMed - indexed for MEDLINE]
0041. Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S.
Endotoxin-induced maturation of MyD88-deficient dendritic cells.
J Immunol. 2001 May 1;166(9):5688-94.
PMID: 11313410 [PubMed - indexed for MEDLINE]
0040. Kaisho T, Takeda K, Tsujimura T, Kawai T, Nomura F, Terada N, Akira S.
IkappaB kinase alpha is essential for mature B cell development and function.
J Exp Med. 2001 Feb 19;193(4):417-26.
PMID: 11181694 [PubMed - indexed for MEDLINE]
0039. Sato S, Nomura F, Kawai T, Takeuchi O, M?hlradt PF, Takeda K, Akira S.
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways.
J Immunol. 2000 Dec 15;165(12):7096-101.
PMID: 11120839 [PubMed - indexed for MEDLINE]
0038. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S.
A Toll-like receptor recognizes bacterial DNA.
Nature. 2000 Dec 7;408(6813):740-5. Erratum in: Nature 2001 Feb 1;409(6820):646.
PMID: 11130078 [PubMed - indexed for MEDLINE]
0037. Takeuchi O, Hoshino K, Akira S.
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.
J Immunol. 2000 Nov 15;165(10):5392-6.
PMID: 11067888 [PubMed - indexed for MEDLINE]
0036. Sakao Y, Kawai T, Takeuchi O, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.
Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting.
Genomics. 2000 Jul 1;67(1):1-7.
PMID: 10945464 [PubMed - indexed for MEDLINE]
0035. Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, Nakanishi K, Kimoto M, Miyake K, Takeda K, Akira S.
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.
J Immunol. 2000 Apr 1;164(7):3476-9.
PMID: 10725699 [PubMed - indexed for MEDLINE]
0034. Nomura F, Kawai T, Nakanishi K, Akira S.
NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.
Genes Cells. 2000 Mar;5(3):191-202.
PMID: 10759890 [PubMed - indexed for MEDLINE]
0033. Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, M?hlradt PF, Akira S.
Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway.
J Immunol. 2000 Jan 15;164(2):554-7.
PMID: 10623793 [PubMed - indexed for MEDLINE]
0032. Takeuchi O, Takeda K, Hoshino K, Adachi O, Ogawa T, Akira S.
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades.
Int Immunol. 2000 Jan;12(1):113-7.
PMID: 10607756 [PubMed - indexed for MEDLINE]
0031. Kaisho T, Tsutsui H, Tanaka T, Tsujimura T, Takeda K, Kawai T, Yoshida N, Nakanishi K, Akira S.
Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice.
J Exp Med. 1999 Dec 6;190(11):1573-82.
PMID: 10587348 [PubMed - indexed for MEDLINE]
0030. Hoshino K, Kashiwamura S, Kuribayashi K, Kodama T, Tsujimura T, Nakanishi K, Matsuyama T, Takeda K, Akira S.
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function.
J Exp Med. 1999 Nov 15;190(10):1541-8.
PMID: 10562328 [PubMed - indexed for MEDLINE]
0029. Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Akira S.
A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
J Immunol. 1999 Nov 1;163(9):5039-48.
PMID: 10528209 [PubMed - indexed for MEDLINE]
0028. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S.
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Immunity. 1999 Oct;11(4):443-51.
PMID: 10549626 [PubMed - indexed for MEDLINE]
0027. Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S.
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
Int Immunol. 1999 Aug;11(8):1357-62.
PMID: 10421793 [PubMed - indexed for MEDLINE]
0026. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S.
Unresponsiveness of MyD88-deficient mice to endotoxin.
Immunity. 1999 Jul;11(1):115-22.
PMID: 10435584 [PubMed - indexed for MEDLINE]
0025. Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S.
Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
Oncogene. 1999 Jun 10;18(23):3471-80.
PMID: 10376525 [PubMed - indexed for MEDLINE]
0024. Hoshino K, Tsutsui H, Kawai T, Takeda K, Nakanishi K, Takeda Y, Akira S.
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.
J Immunol. 1999 May 1;162(9):5041-4.
PMID: 10227969 [PubMed - indexed for MEDLINE]
0023. Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.
TLR6: A novel member of an expanding toll-like receptor family.
Gene. 1999 Apr 29;231(1-2):59-65.
PMID: 10231569 [PubMed - indexed for MEDLINE]
0022. Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S.
Limb and skin abnormalities in mice lacking IKKalpha.
Science. 1999 Apr 9;284(5412):313-6.
PMID: 10195895 [PubMed - indexed for MEDLINE]
0021. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S.
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.
J Immunol. 1999 Apr 1;162(7):3749-52.
PMID: 10201887 [PubMed - indexed for MEDLINE]
0020. Sakao Y, Takeda K, Tsutsui H, Kaisho T, Nomura F, Okamura H, Nakanishi K, Akira S.
IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock.
Int Immunol. 1999 Mar;11(3):471-80.
PMID: 10221659 [PubMed - indexed for MEDLINE]
0019. Kawai T, Sanjo H, Akira S.
Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.
Gene. 1999 Feb 18;227(2):249-55.
PMID: 10023074 [PubMed - indexed for MEDLINE]
0018. Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, F?rster I, Akira S.
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.
Immunity. 1999 Jan;10(1):39-49.
PMID: 10023769 [PubMed - indexed for MEDLINE]
0017. Tanaka T, Tsujimura T, Takeda K, Sugihara A, Maekawa A, Terada N, Yoshida N, Akira S.
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.
Genes Cells. 1998 Dec;3(12):801-10.
PMID: 10096021 [PubMed - indexed for MEDLINE]
0016. Matsumoto M, Sakao Y, Akira S.
Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line.
Int Immunol. 1998 Dec;10(12):1825-35.
PMID: 9885903 [PubMed - indexed for MEDLINE]
0015. Akaishi H, Takeda K, Kaisho T, Shineha R, Satomi S, Takeda J, Akira S.
Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes.
Int Immunol. 1998 Nov;10(11):1747-51.
PMID: 9846704 [PubMed - indexed for MEDLINE]
0014. Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S.
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.
J Immunol. 1998 Nov 1;161(9):4652-60.
PMID: 9794394 [PubMed - indexed for MEDLINE]
0013. Sanjo H, Kawai T, Akira S.
DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis.
J Biol Chem. 1998 Oct 30;273(44):29066-71.
PMID: 9786912 [PubMed - indexed for MEDLINE]
0012. Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S.
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Immunity. 1998 Jul;9(1):143-50.
PMID: 9697844 [PubMed - indexed for MEDLINE]
0011. Shimada T, Matsumoto M, Tatsumi Y, Kanamaru A, Akira S.
A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages.
FEBS Lett. 1998 Apr 3;425(3):490-4.
PMID: 9563519 [PubMed - indexed for MEDLINE]
0010. Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, Okamura H, Nakanishi K, Akira S.
Defective NK cell activity and Th1 response in IL-18-deficient mice.
Immunity. 1998 Mar;8(3):383-90.
PMID: 9529155 [PubMed - indexed for MEDLINE]
0009. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Mol Cell Biol. 1998 Mar;18(3):1642-51.
PMID: 9488481 [PubMed - indexed for MEDLINE]
0008. Tanaka T, Yoshida N, Kishimoto T, Akira S.
Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene.
EMBO J. 1997 Dec 15;16(24):7432-43.
PMID: 9405372 [PubMed - indexed for MEDLINE]
0007. Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, Kishimoto T, Akira S.
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3801-4.
PMID: 9108058 [PubMed - indexed for MEDLINE]
0006. Inoue M, Minami M, Matsumoto M, Kishimoto T, Akira S.
The amino acid residues immediately carboxyl-terminal to the tyrosine phosphorylation site contribute to interleukin 6-specific activation of signal transducer and activator of transcription 3.
J Biol Chem. 1997 Apr 4;272(14):9550-5.
PMID: 9083098 [PubMed - indexed for MEDLINE]
0005. Matsumoto M, Minami M, Takeda K, Sakao Y, Akira S.
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells.
FEBS Lett. 1996 Oct 21;395(2-3):143-7.
PMID: 8898082 [PubMed - indexed for MEDLINE]
0004. Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S.
Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.
J Immunol. 1996 Oct 15;157(8):3220-2.
PMID: 8871614 [PubMed - indexed for MEDLINE]
0003. Shi W, Inoue M, Minami M, Takeda K, Matsumoto M, Matsuda Y, Kishimoto T, Akira S.
The genomic structure and chromosomal localization of the mouse STAT3 gene.
Int Immunol. 1996 Aug;8(8):1205-11.
PMID: 8918689 [PubMed - indexed for MEDLINE]
0002. Minami M, Inoue M, Wei S, Takeda K, Matsumoto M, Kishimoto T, Akira S.
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3963-6.
PMID: 8632998 [PubMed - indexed for MEDLINE]
0001. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S.
Essential role of Stat6 in IL-4 signalling.
Nature. 1996 Apr 18;380(6575):627-30.
PMID: 8602263 [PubMed - indexed for MEDLINE]

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