DEMOGRAPHIC INFORMATION
Personal data:
Business address: Department of Molecular Protozoology
Research Institute for Microbial Diseases
Osaka University
3-1 Yamada-oka, Suita, Osaka, JAPAN 565-0871
Phone: 81-6-6879-8279 or 8301
Fax: 81-6-6879-8283 or 8301
E-mail: kenishii@biken.osaka-u.ac.jp
Professional experience:
12/2007-Present
Adjunct Associate Professor: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University
12/2006-Present
Associate Professor, Department of Molecular Protozoology
Research Institute for Microbial Diseases, Osaka University, Japan.
10/2003-03/2008
Group Leader, Akira Innate Immunity Project, ERATO, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Japan.
04/2000-09/2003
Staff Scientist, IND primary reviewer, Office of Vaccine Research and Review (OVRR), Center for Biologics and Evaluation Research (CBER), Food and Drug Administration (FDA), Department of Health and Human Services / US Federal Government, Bethesda, MD, USA.
10/1996-04/2000
Post-doctoral Fellow, Office of Vaccine Research and Review (OVRR), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Department of Human Health Services (DHHS), US Federal Government
05/1995-10/1996
Senior Resident, Anesthesiology / ICU, Department of Anesthesiology
School of Medicine, Yokohama City University, Kanagawa, Japan
Prof. Fukuichiro Okumura, professor/advisor
04/1993-04/1995
Residency, Internal Medicine / Surgery / Radiology
School of Medicine, Yokohama City University, Kanagawa, Japan
RESEARCH ACTICVITIES
Publications (selected):
Peer reviewed scientific journals:
1. Ishii KJ*, Akira S*. "Potential link between the immune system and metabolism of nucleic acids." Curr Opin Immunol. 2008 Oct;20(5):524-9. (*Corresponding author)
2. Takeshita F*, Ishii KJ*. "Intracellular DNA sensors in immunity." Curr Opin Immunol. 2008 20(4):383-8 (*Corresponding author)
3. Ishii KJ*, Koyama S, Nakagawa A, Coban C, Akira S*. "Host innate immune receptors and beyond: making sense of microbial infections." Cell Host Microbe. 20083(6):352-63. (*Co-corresponding author)
4. Coban C, Koyama S, Takeshita F, Akira S, Ishii KJ*. "Molecular and cellular mechanisms of DNA vaccines." Hum Vaccin. 2008 4(6). (*Corresponding author)
5. Ishii KJ*, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S*. "TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines." Nature. 2008 451(7179):725-9. (* Co-corresponding author)
6. Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S. "Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses." J Immunol. 2008 180(2):683-7.
7. Koyama S, Ishii KJ*, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S*.
"Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination." J Immunol. 2007 179(7):4711-20. (* Co-corresponding author)
8. Ishii KJ, Akira S. "Toll or Toll-Free Adjuvant Path Toward the Optimal Vaccine Development." J Clin Immunol. 2007 27(4):363-71. (*Corresponding author)
9. Ishii KJ, Uematsu S, Akira S. "'Toll' gates for future immunotherapy." Curr Pharm Des. 2006;12(32):4135-42.
10. Ishii KJ, Akira S. "Innate immune recognition of, and regulation by, DNA."Trends Immunol. 2006 27(11):525-32.
11. Ishii KJ, Coban C, Akira S. "Manifold Mechanisms of Toll-Like Receptor-Ligand recognition." J Clin Immunol. 2005 25(6):511-521.
12. Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S. "A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA." Nat Immunol. 2006 7(1):40-48.
13. Ishii KJ, Akira S."TLR ignores methylated RNA?" Immunity. 2005 23(2):111-3.
14. Ishii KJ, Akira S. "Innate immune recognition of nucleic acids: Beyond toll-like receptors." Int J Cancer. 2005 117(4):517-23.
15. Ishii KJ, Ito S, Tamura T, Hemmi H, Conover J, Ozato K, Akira S, Klinman DM. "CpG-activated Thy1.2(+) dendritic cells protect against lethal Listeria monocytogenes infection." Eur J Immunol. 2005 35(8):2397-405.
16. Sugiyama T, Gursel M, Takeshita F, Coban C, Conover J, Kaisho T, Akira S, Klinman DM and Ishii KJ*. "CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes." J Immunol. 2005 174(4):2273-9. (* Corresponding author)
17. Coban C*, Ishii KJ*, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S. "Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin." J Exp Med. 2005 201(1):19-25. (*Co-first author)
18. Ishii KJ, Gursel I, Gursel M and Klinman DM. " Immunotherapeutic Utility of Stimulatory and Suppressive Oligonucleotides" Curr. Opin. Mol. Ther. 6(2):166-74, 2004.
19. Ishii KJ*, Kawakami K, Gursel I, Klinman DM and Puri RK. "Anti-tumor therapy with
bacterial DNA and toxin: Liposomal CpG ODN plus IL-13 cytotoxin induces complete regression of established human tumor in animal models." Clinical Cancer Research. 9(17): 6516-22, 2003. (* Correspoding author)
20. Ishii KJ, Takeshita F, Gursel I, Gursel M, Nussenzweig A and Klinman DM. "Potential Role of PI3 Kinases, rather than DNA-PK, in CpG DNA Induced Immune Activation" J. Exp. Med. Jul 15;196(2):269-74, 2002.
21. Ishii KJ, Suzuki K, Itoh Y, Coban C, Takeshita F, Matoba H, Kohn LD, Klinman DM. "Genomic DNA released by dying cells induces the maturation of antigen presenting cells." J. Immunol. 167(5): 2602-2607, 2001.
22. Klinman DM, Verthelyi D, Takeshita F, Ishii KJ. "Immune recognition of foreign DNA." Immunity, Vol.11, 123‑129, 1999.
23. Ishii KJ, Weiss WR, Ichino M, Verthelyi D, Hoffman SL, Klinman DM. "Activity and Safety of DNA Plasmids Encoding IL‑4 and IFN gamma." Gene Ther. 6: (2) 237‑244, 1999.
24. Ishii KJ, Weiss WR, Klinman DM. "Prevention of neonatal tolerance by plasmid DNA encoding GMCSF." Vaccine, Vol.18, 703-10, 1999.
Books (editor):
1- Ishii KJ and Akira S. "Nucleic Acids in Innate Immunity" Editor in chief. CRC press, 2008.
Book chapters (selected):
2- Ishii KJ, Koyama S and Akira S. "Overview: Innate immune response to nucleic acids" Immune response to gene therapy, edited by Roland Herzog, Willey Publisher, 2008
3- Ishii KJ, Akira S. "Innate Immunity" Clinical Immunology 3rd Ed. Edited by Rich, Shearer, Fleisher, Schroeder, Weyand, Frew. 2008.
Patents (selected):
1. A novel vaccine adjuvant. Inventor, Ishii Ken, Akira Shizuo, Coban Cevayir, TsukuiToshihiro, Applicant ZENOAQ Inc. Osaka U. PCT/JP2008/69919, JP2007-285737
2. Immunostimulatory DNA complex with beta-1,3 D glucan. Inventor Sakura Kazuo, SHinkai Seiji, Shimada Naohiko, Ishii Ken, Akira Shizuo. Applicant ERATO, SORST/JST JP2006-282148
3. Detection/Measurement of Malaria Infection Disease Utilizing Natural Immunity By Hemozoin Induction, Screening Of Preventive Or Therapeutic Medicine For Malaria Infection Disease, and Regulation Of Natural Immunity Induction. Inventor: Akira Shizuo (JP); Ishii Ken (JP); Coban Cevayir (JP). Applicant: Univ Osaka (JP); Japan Science & Tech Agency (JP); Akira Shizuo (JP); Ishii Ken (JP); Coban Cevayir (JP). Application Number: WO2006061965 - 2006-06-15, WO2005jp20283- 20051104. Priority Number(S): JP20040357255 20041209.
4. Use of Sterically Stabilized Cationic Liposomes To Efficiently Deliver Cpg Oligonucleotides In Vivo. Inventor: Klinman Dennis M (US); Gursel Ihsan (US); Ishii Ken J (US); Kawakami Koji (US); Joshi Bharat H (US); Puri Raj K (US). Applicant: Us Government (US); Klinman Dennis M (US); Gursel Ihsan (US); Ishii Ken J (US); Kawakami Koji (US); Joshi Bharat H (US); Puri Raj K (US). Publication Info: WO03040308 - 2003-05-15.
5. Oligodeoxynucleotide and Its Use to Induce an Immune Response. Inventor: Klinman Dennis [US]; Ishii Ken [US]; Verthelyi Daniela [US]. Applicant: Us Health [US]; Klinman Dennis [US]; Ishii Ken [US]; Verthelyi Daniela [US]. Publication Info: WO0151500 - 2001-07-19, WO0061151 - 2000-10-19, AU4343700 - 2000-11-14, AU2788901 - 2001-07-24, EP1176966 - 2002-02-06, US2003060440 - 2003-03-27, EP1322655 - 2003-07-02.
6. Immune Activation by Double-Stranded Polynucleotides. Inventor: Kohn Leonard D; Suzuki Koichi; Mori Atsumi; Ishii Ken; Klinman Dennis M; Rice John M. Applicant: Kohn Leonard D; Suzuki Koichi; Mori Atsumi; Ishii Ken; Klinman Dennis M; Rice John M. Publication Info: WO0015768 - 2000-03-23, CA2309762 - 2000-03-23, AU6032999 - 2000-04-03, EP1030909 - 2000-08-30, US2002142974 - 2002-10-03 US2005036993 - 2005-02-17.
EDUCATIONAL ACTIVITIES
ORGANIZATIONAL ACTIVITIES
Professional Societies, Memberships:
2007-present The Japanese Society for Vaccinology
2006-present Japanese Society of Parasitology
2006-2007 New York Academy of Science
2006-present Japanese Society of Host Defense Research
2003-present Japanese Association for Immunology
2000-present American Association for the Advancement of Science
2000-present American Association of Immunologists
1995-present Japanese Association for Critical Care Medicine
Other activities:
2008-present
Advisor, Ministry of Health, Pharmaceuticals and Medical Devices Agency
2008-present
Program Officer, Ministry of Education, Culture, Sports, Science and Technology, Japanese Government
2006
Peer review panelist; Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), National Institute of Environmental Health Sciences (NIEHS), U.S. Department Health and Human Services, USA
Honors and Awards:
2008 Japanese Society of Immunology, Young Investigator Award
2008 Osaka University Achievement Award for Education and Research
2007 Naito Foundation Best Poster Award 2007
2003 Department of Health and Human Services individual award for special accomplishment, USA
2002 Department of Health and Human Services individual award for special accomplishment, USA
2001 Department of Health and Human Services individual award for special accomplishment, USA
2000 Department of Health and Human Services individual award for contribution public health mission, USA
1996 Oak Ridge Research Institute post graduate fellowship, Tennessee, USA
