Education and Professional Experience:
1987-1994
MD, Hacettepe University Medical School, Ankara, TURKEY
1995-1998
Degree in Clinical Microbiology, Ankara Numune Education and Training Hospital Clinical Microbiology Department, Ankara, TURKEY
1998-1999
Visiting Fellow, FDA/CBER (Food and Drug Administration), Bethesda, Maryland, USA
2000-2003
Postdoctoral Fellow, Johns Hopkins University School of Public Health, Malaria Research Institute, Baltimore, Maryland, USA
2003-2006
Postdoctoral Fellow, The 21st Century Center of Excellence (COE) Program, Research Institute for Microbial Diseases, Osaka University, Osaka, JAPAN
2006-2008
Specially appointed Assistant Professor, The 21st Century Center of Excellence (COE) Program, Research Institute for Microbial Diseases, Osaka University, Osaka, JAPAN
2008-present
Assistant Professor, Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University, Osaka, JAPAN
Research Interests:
1. Understanding the role of innate immunity against malaria infection
2. The effect of "malaria pigment" hemozoin on immune system
3. Research and development on new adjuvants and vaccines
4. Understanding the mechanism of DNA vaccines
Honors and Awards:
2008 Grant Challenges/Explorations, Round 1 Recipient, Bill and Melinda Gates Foundation, USA
2004 Research fellowship, The 21st Century Center of Excellence (COE) Program, Osaka University, JAPAN
2000 NIH Postdoctoral fellowship, Johns Hopkins University School of Public Health, USA
1999 Oak Ridge Research Institute (ORISE) fellowship, FDA/CBER, USA
1998 Research fellowship, Turkish Ministry of Health, TURKEY
Selected Publications:
1. Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S. Host Innate Immune Receptors: Making Sense of Microbial Infections. Review, Cell Host and Microbe, 2008, 3(6):352-363.
2. Coban C, Koyama S, Takeshita F, Akira S, IshiiKJ. Molecular and cellular mechanisms of DNA vaccines. Review, Human Vaccines, 2008, 4(6):453-456.
3. Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S. Tank-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature, 2008, 451(7179):725-729.
4. Coban C, Ishii KJ, Horii T, Akira S. Innate immune interaction between the host and the malaria parasite. Review, Trends in Microbiology, 2007, 15(6): 271-278.
5. Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S. Pathological role of Toll-like receptor signaling on cerebral malaria. International Immunology, 2007, 19(1):67-79.
6. Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nature Immunology, 2006, 7(1):40-48.
7. Ishii KJ, Coban C, Akira S. Manifold Mechanisms of Toll-like Receptor-Ligand Recognition. Review. Journal of Clinical Immunology, 2005, 25(6):511-521.
8. Coban C, Ishii KJ, Gursel M, Klinman DM, Kumar N. Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors. Journal of Leukocyte Biology, 2005, 78(3):647-55.
9. Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. Journal of Experimental Medicine, 2005, 201(1):19-25.
10. Coban C, Philipp MT, Purcell JE, Keister DB, Okulate M, Martin DS, Kumar N. Induction of Plasmodium falciparum Transmission Blocking Antibodies in Nonhuman Primates by a Combination of DNA and Protein Immunizations. Infection and Immunity, 2004, 72(1):253-259.
11. Coban C, Ishii KJ, Stowers AW, Keister DB, Klinman DM, Kumar N. Effect of CpG Oligodeoxynucleotides on the Immunogenicity of Pfs25, a Plasmodium falciparum Transmission Blocking Vaccine. Infection and Immunity, 2004, 72(1):584-588.
12. Coban C, Ishii KJ, Sullivan DJ, Kumar N. Purified Malaria Pigment (Hemozoin) Enhances Dendritic Cell Maturation and Modulates the Isotype of Antibodies Induced by a DNA Vaccine. Infection and Immunity, 2002, 70(7): 3939-3943.
1987-1994
MD, Hacettepe University Medical School, Ankara, TURKEY
1995-1998
Degree in Clinical Microbiology, Ankara Numune Education and Training Hospital Clinical Microbiology Department, Ankara, TURKEY
1998-1999
Visiting Fellow, FDA/CBER (Food and Drug Administration), Bethesda, Maryland, USA
2000-2003
Postdoctoral Fellow, Johns Hopkins University School of Public Health, Malaria Research Institute, Baltimore, Maryland, USA
2003-2006
Postdoctoral Fellow, The 21st Century Center of Excellence (COE) Program, Research Institute for Microbial Diseases, Osaka University, Osaka, JAPAN
2006-2008
Specially appointed Assistant Professor, The 21st Century Center of Excellence (COE) Program, Research Institute for Microbial Diseases, Osaka University, Osaka, JAPAN
2008-present
Assistant Professor, Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University, Osaka, JAPAN
Research Interests:
1. Understanding the role of innate immunity against malaria infection
2. The effect of "malaria pigment" hemozoin on immune system
3. Research and development on new adjuvants and vaccines
4. Understanding the mechanism of DNA vaccines
Honors and Awards:
2008 Grant Challenges/Explorations, Round 1 Recipient, Bill and Melinda Gates Foundation, USA
2004 Research fellowship, The 21st Century Center of Excellence (COE) Program, Osaka University, JAPAN
2000 NIH Postdoctoral fellowship, Johns Hopkins University School of Public Health, USA
1999 Oak Ridge Research Institute (ORISE) fellowship, FDA/CBER, USA
1998 Research fellowship, Turkish Ministry of Health, TURKEY
Selected Publications:
1. Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S. Host Innate Immune Receptors: Making Sense of Microbial Infections. Review, Cell Host and Microbe, 2008, 3(6):352-363.
2. Coban C, Koyama S, Takeshita F, Akira S, IshiiKJ. Molecular and cellular mechanisms of DNA vaccines. Review, Human Vaccines, 2008, 4(6):453-456.
3. Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S. Tank-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature, 2008, 451(7179):725-729.
4. Coban C, Ishii KJ, Horii T, Akira S. Innate immune interaction between the host and the malaria parasite. Review, Trends in Microbiology, 2007, 15(6): 271-278.
5. Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S. Pathological role of Toll-like receptor signaling on cerebral malaria. International Immunology, 2007, 19(1):67-79.
6. Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nature Immunology, 2006, 7(1):40-48.
7. Ishii KJ, Coban C, Akira S. Manifold Mechanisms of Toll-like Receptor-Ligand Recognition. Review. Journal of Clinical Immunology, 2005, 25(6):511-521.
8. Coban C, Ishii KJ, Gursel M, Klinman DM, Kumar N. Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors. Journal of Leukocyte Biology, 2005, 78(3):647-55.
9. Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. Journal of Experimental Medicine, 2005, 201(1):19-25.
10. Coban C, Philipp MT, Purcell JE, Keister DB, Okulate M, Martin DS, Kumar N. Induction of Plasmodium falciparum Transmission Blocking Antibodies in Nonhuman Primates by a Combination of DNA and Protein Immunizations. Infection and Immunity, 2004, 72(1):253-259.
11. Coban C, Ishii KJ, Stowers AW, Keister DB, Klinman DM, Kumar N. Effect of CpG Oligodeoxynucleotides on the Immunogenicity of Pfs25, a Plasmodium falciparum Transmission Blocking Vaccine. Infection and Immunity, 2004, 72(1):584-588.
12. Coban C, Ishii KJ, Sullivan DJ, Kumar N. Purified Malaria Pigment (Hemozoin) Enhances Dendritic Cell Maturation and Modulates the Isotype of Antibodies Induced by a DNA Vaccine. Infection and Immunity, 2002, 70(7): 3939-3943.
