Shizuo Akira, M.D., Ph.D. :Professor, Director

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Education history

Osaka University School of Medicine (1977)

Osaka University, Graduate School of Medicine (1984)



Research & career history

Clinical Training and Physician (1977-1980)

Research Fellow, University of California, Berkeley (1985-1987)

Research Associate (1987-1995), Associate Professor (1995), Institute for Molecular and Cellular Biology, Osaka University

Professor, Hyogo College of Medicine (1996-1999)

Professor, Research Institute for Microbial Diseases, Osaka University (1999-present)

Center Director, Osaka University Immunology Frontier Research Center (2007-present)



Publications


Research articles (Selected)


Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

Immunity. 2011 Mar 25;34(3):352-63.

   

Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S.

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA.

Immunity. 2010 Nov 24;33(5):765-76.


Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S.

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.

Nat Immunol. 2010 Oct;11(10):936-44. 


Kawagoe T, Takeuchi O, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S. 

TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. 

Nat Immunol. 2009 Sep;10(9):965-72. 


Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S. 

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. 

Nature. 2009 Apr 30;458(7242):1185-90.

 

Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S. 

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. 

Nature. 2008 Nov 13;456(7219):264-8.

 

Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. 

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. 

Nat Immunol. 2008 Jul;9(7):769-76.

 

Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S. 

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. 

Nat Immunol. 2008 Jun;9(6):684-91.

 

Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S. 

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. 

Nature. 2008 Feb 7;451(7179):725-9.

 

Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa K, Kawai T, Akira S. 

Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. 

Immunity. 2007 Aug;27(2):240-52.

 

Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S. 

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. 

Nat Immunol. 2006 Sep;7(9):962-70.

 

Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S. 

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. 

Nat Immunol. 2006 Aug;7(8):868-74.

 

Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S. 

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. 

Nature. 2006 May 4;441(7089):101-5.

 

Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S. 

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. 

Nat Immunol. 2006 Jan;7(1):40-8.

 

Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S. 

Essential function for the kinase TAK1 in innate and adaptive immune responses. 

Nat Immunol. 2005 Nov;6(11):1087-95.

 

Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S. 

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. 

Nat Immunol. 2005 Oct;6(10):981-8.

 

Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S. 

Cell type-specific involvement of RIG-I in antiviral response. 

Immunity. 2005 Jul;23(1):19-28.

 

Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue J, Uematsu S, Takeuchi O, Akira S. 

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. 

Nat Immunol. 2004 Oct;5(10):1061-8.

 

Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S. 

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. 

Nature. 2004 Jul 8;430(6996):218-22.

 

Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S. 

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. 

Nat Immunol. 2003 Nov;4(11):1144-50.

 

Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. 

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. 

Science. 2003 Aug 1;301(5633):640-3.

 

Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S. 

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. 

Nature. 2002 Nov 21;420(6913):324-9.

 

Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S. 

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. 

Nat Immunol. 2002 Feb;3(2):196-200.

 

Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. 

A Toll-like receptor recognizes bacterial DNA. 

Nature. 2000 Dec 7;408(6813):740-5.

 

Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S. 

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. 

Immunity. 1999 Oct;11(4):443-51.

 

Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S. 

Limb and skin abnormalities in mice lacking IKKalpha. 

Science. 1999 Apr 9;284(5412):313-6.

 

Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S. 

Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. 

J Immunol. 1999 Apr 1;162(7):3749-52.

 

Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. 

Unresponsiveness of MyD88-deficient mice to endotoxin. 

Immunity. 1999 Jul;11(1):115-22.

 

Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, Förster I, Akira S. 

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. 

Immunity. 1999 Jan;10(1):39-49.

 

Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S. 

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. 

Immunity. 1998 Jul;9(1):143-50.

 

Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, Okamura H, Nakanishi K, Akira S.

Defective NK cell activity and Th1 response in IL-18-deficient mice. 

Immunity. 1998 Mar;8(3):383-90.

 

Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S. 

Essential role of Stat6 in IL-4 signalling. 

Nature. 1996 Apr 18;380(6575):627-30.


Reviews (Selected)


Kawai T, Akira S.

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.

Nat Immunol. 2010 May;11(5):373-84. 


Takeuchi O, Akira S.

Pattern recognition receptors and inflammation.

Cell. 2010 Mar 19;140(6):805-20. 


Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S.  

Host innate immune receptors and beyond: making sense of microbial infections. 

Cell Host Microbe. 2008 Jun 12;3(6):352-63.

 

Akira S, Uematsu S, Takeuchi O. 

Pathogen recognition and innate immunity. 

Cell. 2006 Feb 24;124(4):783-801.

 

Kawai T, Akira S. 

Innate immune recognition of viral infection. 

Nat Immunol. 2006 Feb;7(2):131-7.

 

Akira S, Takeda K. 

Toll-like receptor signalling. 

Nat Rev Immunol. 2004 Jul;4(7):499-511.

 

Takeda K, Kaisho T, Akira S. 

Toll-like receptors. 

Annu Rev Immunol. 2003;21:335-76.

 

Akira S, Takeda K, Kaisho T. 

Toll-like receptors: critical proteins linking innate and acquired immunity. 

Nat Immunol. 2001 Aug;2(8):675-80.



Prize

2000     Inoue Prize for Science

2001     Hideyo Noguchi Prize

2002     Osaka Science Prize

2003     Takeda Medical Prize

2004     Prize of Princess Takamatsu Cancer Research Fund

2004     Robert Koch Prize

2005     The Emperor's Purple Ribbon Medal

2006     Asahi Prize

2006     William B Coley Award

2007     Thompson Scientific Research Award 2007

2007     Uehara Prize

2007     The Japan Academy Award The Imperial Award

2007     Milstein Award

2009     Foreign associate, National Academy of Sciences

2009     Person of Cultural Merit

2010     Avery-Landsteiner Prize

2010     Keio Medical Science Prize

2011     The Canada Gairdner International Award



Special mention

* "Hottest Researcher" in all research fields for two consecutive years (2006 and 2007) (Thomson Scientific Research)

* The top cited immunologist since 2004 (Thomson Scientific Research)

* Doctor of Medical Science at Technical University of Munich (2007)

* Dunham lecture at Harvard University (2007)

* Dyer lecture at National Institutes of Health (2008)


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